ZFAN3_HUMAN
ID ZFAN3_HUMAN Reviewed; 227 AA.
AC Q9H8U3; Q5SZZ0; Q5SZZ1;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=AN1-type zinc finger protein 3;
DE AltName: Full=Testis-expressed protein 27;
GN Name=ZFAND3; Synonyms=TEX27;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP STRUCTURE BY NMR OF 147-200 IN COMPLEX WITH ZINC IONS.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the ZF-AN1 domain from human hypothetical protein
RT FLJ13222.";
RL Submitted (NOV-2005) to the PDB data bank.
CC -!- INTERACTION:
CC Q9H8U3; B3EWG5: FAM25C; NbExp=3; IntAct=EBI-725171, EBI-14240149;
CC Q9H8U3; Q0VD86: INCA1; NbExp=3; IntAct=EBI-725171, EBI-6509505;
CC Q9H8U3; P50542-3: PEX5; NbExp=3; IntAct=EBI-725171, EBI-12181987;
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DR EMBL; AK023284; BAB14508.1; -; mRNA.
DR EMBL; AL121574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL133377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL589655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031481; AAH31481.1; -; mRNA.
DR CCDS; CCDS4836.1; -.
DR RefSeq; NP_068762.1; NM_021943.2.
DR PDB; 1X4W; NMR; -; A=147-200.
DR PDBsum; 1X4W; -.
DR AlphaFoldDB; Q9H8U3; -.
DR SMR; Q9H8U3; -.
DR BioGRID; 121958; 12.
DR IntAct; Q9H8U3; 5.
DR STRING; 9606.ENSP00000287218; -.
DR iPTMnet; Q9H8U3; -.
DR PhosphoSitePlus; Q9H8U3; -.
DR BioMuta; ZFAND3; -.
DR DMDM; 74733896; -.
DR EPD; Q9H8U3; -.
DR jPOST; Q9H8U3; -.
DR MassIVE; Q9H8U3; -.
DR MaxQB; Q9H8U3; -.
DR PaxDb; Q9H8U3; -.
DR PeptideAtlas; Q9H8U3; -.
DR PRIDE; Q9H8U3; -.
DR ProteomicsDB; 81242; -.
DR Antibodypedia; 15614; 194 antibodies from 23 providers.
DR DNASU; 60685; -.
DR Ensembl; ENST00000287218.9; ENSP00000287218.4; ENSG00000156639.12.
DR GeneID; 60685; -.
DR KEGG; hsa:60685; -.
DR MANE-Select; ENST00000287218.9; ENSP00000287218.4; NM_021943.3; NP_068762.1.
DR UCSC; uc003onx.4; human.
DR CTD; 60685; -.
DR DisGeNET; 60685; -.
DR GeneCards; ZFAND3; -.
DR HGNC; HGNC:18019; ZFAND3.
DR HPA; ENSG00000156639; Low tissue specificity.
DR MIM; 607455; gene.
DR neXtProt; NX_Q9H8U3; -.
DR OpenTargets; ENSG00000156639; -.
DR PharmGKB; PA38277; -.
DR VEuPathDB; HostDB:ENSG00000156639; -.
DR eggNOG; KOG3173; Eukaryota.
DR GeneTree; ENSGT00390000014679; -.
DR InParanoid; Q9H8U3; -.
DR OMA; HDCEIDF; -.
DR OrthoDB; 1440530at2759; -.
DR PhylomeDB; Q9H8U3; -.
DR TreeFam; TF354281; -.
DR PathwayCommons; Q9H8U3; -.
DR SignaLink; Q9H8U3; -.
DR BioGRID-ORCS; 60685; 14 hits in 1085 CRISPR screens.
DR ChiTaRS; ZFAND3; human.
DR EvolutionaryTrace; Q9H8U3; -.
DR GenomeRNAi; 60685; -.
DR Pharos; Q9H8U3; Tbio.
DR PRO; PR:Q9H8U3; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9H8U3; protein.
DR Bgee; ENSG00000156639; Expressed in left testis and 195 other tissues.
DR ExpressionAtlas; Q9H8U3; baseline and differential.
DR Genevisible; Q9H8U3; HS.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 4.10.1110.10; -; 1.
DR InterPro; IPR035896; AN1-like_Znf.
DR InterPro; IPR002653; Znf_A20.
DR InterPro; IPR000058; Znf_AN1.
DR Pfam; PF01754; zf-A20; 1.
DR Pfam; PF01428; zf-AN1; 1.
DR SMART; SM00259; ZnF_A20; 1.
DR SMART; SM00154; ZnF_AN1; 1.
DR SUPFAM; SSF118310; SSF118310; 1.
DR PROSITE; PS51036; ZF_A20; 1.
DR PROSITE; PS51039; ZF_AN1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..227
FT /note="AN1-type zinc finger protein 3"
FT /id="PRO_0000076370"
FT ZN_FING 12..44
FT /note="A20-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00451"
FT ZN_FING 151..200
FT /note="AN1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT REGION 41..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 18
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00451"
FT BINDING 20
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00451"
FT BINDING 32
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00451"
FT BINDING 35
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00451"
FT BINDING 157
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 160
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 174
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 176
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 181
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 184
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 190
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 192
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT STRAND 158..160
FT /evidence="ECO:0007829|PDB:1X4W"
FT HELIX 166..172
FT /evidence="ECO:0007829|PDB:1X4W"
FT STRAND 175..177
FT /evidence="ECO:0007829|PDB:1X4W"
FT TURN 182..184
FT /evidence="ECO:0007829|PDB:1X4W"
FT HELIX 188..190
FT /evidence="ECO:0007829|PDB:1X4W"
SQ SEQUENCE 227 AA; 25184 MW; 609F2B793F835E47 CRC64;
MGDAGSERSK APSLPPRCPC GFWGSSKTMN LCSKCFADFQ KKQPDDDSAP STSNSQSDLF
SEETTSDNNN TSITTPTLSP SQQPLPTELN VTSPSKEECG PCTDTAHVSL ITPTKRSCGT
DSQSENEASP VKRPRLLENT ERSEETSRSK QKSRRRCFQC QTKLELVQQE LGSCRCGYVF
CMLHRLPEQH DCTFDHMGRG REEAIMKMVK LDRKVGRSCQ RIGEGCS
