ZFAN4_MOUSE
ID ZFAN4_MOUSE Reviewed; 739 AA.
AC D3Z3C6;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 24-JUN-2015, sequence version 2.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=AN1-type zinc finger protein 4;
DE AltName: Full=AN1-type zinc finger and ubiquitin domain-containing protein-like 1;
GN Name=Zfand4; Synonyms=Anubl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
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DR EMBL; AC123548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC147612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS71818.2; -.
DR RefSeq; NP_001296375.1; NM_001309446.1.
DR RefSeq; XP_006506569.1; XM_006506506.3.
DR RefSeq; XP_006506570.1; XM_006506507.3.
DR PDB; 1WFF; NMR; -; A=659-730.
DR PDBsum; 1WFF; -.
DR AlphaFoldDB; D3Z3C6; -.
DR SMR; D3Z3C6; -.
DR STRING; 10090.ENSMUSP00000108521; -.
DR iPTMnet; D3Z3C6; -.
DR PhosphoSitePlus; D3Z3C6; -.
DR PaxDb; D3Z3C6; -.
DR PRIDE; D3Z3C6; -.
DR ProteomicsDB; 298517; -.
DR Antibodypedia; 27027; 33 antibodies from 12 providers.
DR Ensembl; ENSMUST00000036503; ENSMUSP00000040057; ENSMUSG00000042213.
DR GeneID; 67492; -.
DR KEGG; mmu:67492; -.
DR UCSC; uc012eqw.2; mouse.
DR CTD; 93550; -.
DR MGI; MGI:1914742; Zfand4.
DR VEuPathDB; HostDB:ENSMUSG00000042213; -.
DR eggNOG; KOG0001; Eukaryota.
DR eggNOG; KOG3173; Eukaryota.
DR GeneTree; ENSGT00940000155716; -.
DR InParanoid; D3Z3C6; -.
DR OrthoDB; 1551371at2759; -.
DR BioGRID-ORCS; 67492; 2 hits in 54 CRISPR screens.
DR ChiTaRS; Zfand4; mouse.
DR PRO; PR:D3Z3C6; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; D3Z3C6; protein.
DR Bgee; ENSMUSG00000042213; Expressed in spermatid and 198 other tissues.
DR ExpressionAtlas; D3Z3C6; baseline and differential.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 4.10.1110.10; -; 1.
DR InterPro; IPR035896; AN1-like_Znf.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR019956; Ubiquitin_dom.
DR InterPro; IPR000058; Znf_AN1.
DR Pfam; PF00240; ubiquitin; 1.
DR Pfam; PF01428; zf-AN1; 1.
DR PRINTS; PR00348; UBIQUITIN.
DR SMART; SM00213; UBQ; 1.
DR SMART; SM00154; ZnF_AN1; 1.
DR SUPFAM; SSF118310; SSF118310; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
DR PROSITE; PS51039; ZF_AN1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..739
FT /note="AN1-type zinc finger protein 4"
FT /id="PRO_0000416000"
FT DOMAIN 54..129
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT ZN_FING 673..720
FT /note="AN1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT REGION 246..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 679
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 682
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 694
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 696
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 701
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 704
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 710
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 712
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
SQ SEQUENCE 739 AA; 81554 MW; 89D98E860AAE3FAC CRC64;
MFKADLGRIG IQLHTTYSRR IRKVKVMDNR KEPPFFNEDN VGPFYFKLPF YDTMELFIET
LTGTCFELRV SPFEAVISVK GKIQRLEGIP ICQQHLIWNN MELEDDYCLN DYNISEGCTL
KLVLAMRGGP ISTRKVPVED PLRELAEYMD SSRDEVWEKT SCNKQVTFLV YREGDQLNFF
RVVDRGDGTL TPLSESLSGS VYNLYTDEDE EAEPSPSGQQ IIENSITMNK MKLLKAKMEN
MNLSKKPKKV VKVKPRPPLA PRPTSSSTAA ARHRLLRVLP HIGQSCLPSG NAHLPETSRN
AGPSPAAQAP ADRPVSSLRN ELLKDDDNWE INMLSHSTSS IRLLPQLTHI ELESDKELAD
SVLHLGSSLS RRTKHLSGNL LSNNEDDVVL FPRSEECVAD ELLLPEVGAF APFAEGTGAE
QSSGVEGLGK VTPEFPLTKG DGGLRAAEQP LSHVARVLSS EPGDNAVLNH REPSSHKNRL
LSPLLCAAPV SLHNSLVKPQ RQSKCFESGN PSASTSQNTL RELDIRTIAD SSFSRTARFR
GVKVDSPGKR SDIISKVEAR DITEMANKAS KEPVGCVNNN GFLASLARSA SRDSLQSTHG
ACRLRSSGIG LSTNFQHFQD ENIRKSSPQS EPTDFFLSAR GIGMSGSNAA AGKRIGESIH
HLPPVKAPLQ TKKKIMKHCF LCGKKTGLAT SFECRCGNNF CASHRYAEAH GCTYDYKSAG
RRYLEEANPV VNAPKLPKI
