ID   ZFA_MOUSE               Reviewed;         742 AA.
AC   P23607;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 150.
DE   RecName: Full=Zinc finger autosomal protein;
GN   Name=Zfa;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1691708; DOI=10.1002/j.1460-2075.1990.tb08271.x;
RA   Ashworth A., Skene B., Swift S., Lovell-Badge R.;
RT   "Zfa is an expressed retroposon derived from an alternative transcript of
RT   the Zfx gene.";
RL   EMBO J. 9:1529-1534(1990).
CC   -!- FUNCTION: Probable transcriptional activator. ZFA is an expressed
CC       retroposon derived from an alternative transcript of the ZFX gene.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. ZFX/ZFY subfamily. {ECO:0000305}.
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DR   EMBL; X53250; CAA37338.1; -; Genomic_DNA.
DR   PIR; S12533; S12533.
DR   AlphaFoldDB; P23607; -.
DR   SMR; P23607; -.
DR   iPTMnet; P23607; -.
DR   PhosphoSitePlus; P23607; -.
DR   MaxQB; P23607; -.
DR   PeptideAtlas; P23607; -.
DR   PRIDE; P23607; -.
DR   UCSC; uc029qxe.1; mouse.
DR   MGI; MGI:99153; Zfa.
DR   InParanoid; P23607; -.
DR   PhylomeDB; P23607; -.
DR   TreeFam; TF335557; -.
DR   PRO; PR:P23607; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P23607; protein.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR006794; Transcrp_activ_Zfx/Zfy-dom.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 6.
DR   Pfam; PF04704; Zfx_Zfy_act; 2.
DR   SMART; SM00355; ZnF_C2H2; 13.
DR   SUPFAM; SSF57667; SSF57667; 7.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..742
FT                   /note="Zinc finger autosomal protein"
FT                   /id="PRO_0000047256"
FT   ZN_FING         362..384
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         393..415
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         425..447
FT                   /note="C2H2-type 3; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         456..479
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         485..507
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         513..536
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         542..564
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         570..593
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         599..621
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         627..650
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         656..678
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         684..707
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         713..736
FT                   /note="C2H2-type 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   742 AA;  84658 MW;  24F7FA08C8CC2DBE CRC64;
     MKMDLNYNNK HQTHFLMQQE LVAPHMDGSQ IVVEVQETVY VSDVVDSDII VHNYVPDDPD
     SVVIQDVIED VVIEDVQCTD IMDEADVSET VIIPEQVLNS DVTEEVSLTH CTVPDDVLAS
     DITSASISMP KRVLTSESIH VSDIGHVEHV VHDSVVEAEI ITDPLATDVV SEEVLVADCA
     SEAVIDANRI PVNQQDEEKN NCEDYLMISC GTVDIVESEP ENELGVELLD PNNSICVPRE
     KMVYMAVNNS QQEEELNVTE IADEIYMEVI VGEEDATASE HEQQVEDNKM KTFMPIAWEA
     AYGNNSDGIE NRNGTASALL HIDESAGLGR LAKQKPKKRR PDSRQYQTAI IIGPDGHPLT
     VYPCMICGKK FKSRGFLKRH MKNHPEHLAK KKYRCTDCDY TTNKKISLHN HLESHKLTSK
     AEKAIECDEY GKHFSHAGAL FTHKMVHKEK GANKMHKCKF CEYETAEQGL LNRHLLAVHS
     KNFPHICVEC GKGFCHPSEL KKHMRIHTGE KPYECQYCEY RSTDSSNLKT HVKTKHSKEM
     PFKCDICLLT FSDTKEVQQH ALVHQESKTH QCLHCDHKSS NSSDLKRHII SVHTKDYPHK
     CDMCDKGFHR PSELKKHVAA HKGKKTHQCR HCDFKIADPF VLSRHILSVH TKDLPFRCKR
     CRTRFRQQSE LKKHMKTHSG QKVYQCEYCD YSTTDASGFK RHVISIHTKD YPHCCEHCKK
     GFRRPSEKNQ HIMRHHKEVG LP