ZFH2_DROME
ID ZFH2_DROME Reviewed; 3005 AA.
AC P28167; Q95SN9; Q9V4D7;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 2.
DT 03-AUG-2022, entry version 188.
DE RecName: Full=Zinc finger protein 2;
DE AltName: Full=Zinc finger homeodomain protein 2;
GN Name=zfh2; Synonyms=zfh-2; ORFNames=CG1449;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1680376; DOI=10.1016/0925-4773(91)90048-b;
RA Fortini M.E., Lai Z., Rubin G.M.;
RT "The Drosophila zfh-1 and zfh-2 genes encode novel proteins containing both
RT zinc-finger and homeodomain motifs.";
RL Mech. Dev. 34:113-122(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE OF 2146-2353.
RC STRAIN=Crete24, Crete26, Crete30, Crete31, Crete35, Crete40, Crete42,
RC Crete43, Crete44, Crete8, FTF1, FTF105, FTF14, FTF2, FTF20, FTF23, FTF26,
RC FTF28, FTF5, FTF6, Zim11, Zim2, Zim30, and Zim53;
RA Sheldahl L.A., Weinreich D.M., Rand D.M.;
RT "Recombination, dominance and selection on amino acid polymorphism in the
RT Drosophila genome: contrasting patterns on the X and 4th chromosomes.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2830-3005.
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1337; SER-2361; SER-2450;
RP SER-2451; SER-2749 AND SER-2751, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Involved in the development of the embryonic central nervous
CC system.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Largely restricted to the CNS of late embryo.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL28229.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M63450; AAA29051.1; -; mRNA.
DR EMBL; AE014135; AAF59339.2; -; Genomic_DNA.
DR EMBL; AY312816; AAQ67630.1; -; Genomic_DNA.
DR EMBL; AY312817; AAQ67631.1; -; Genomic_DNA.
DR EMBL; AY312818; AAQ67632.1; -; Genomic_DNA.
DR EMBL; AY312819; AAQ67633.1; -; Genomic_DNA.
DR EMBL; AY312820; AAQ67634.1; -; Genomic_DNA.
DR EMBL; AY312821; AAQ67635.1; -; Genomic_DNA.
DR EMBL; AY312822; AAQ67636.1; -; Genomic_DNA.
DR EMBL; AY312823; AAQ67637.1; -; Genomic_DNA.
DR EMBL; AY312824; AAQ67638.1; -; Genomic_DNA.
DR EMBL; AY312825; AAQ67639.1; -; Genomic_DNA.
DR EMBL; AY312826; AAQ67640.1; -; Genomic_DNA.
DR EMBL; AY312827; AAQ67641.1; -; Genomic_DNA.
DR EMBL; AY312828; AAQ67642.1; -; Genomic_DNA.
DR EMBL; AY312829; AAQ67643.1; -; Genomic_DNA.
DR EMBL; AY312830; AAQ67644.1; -; Genomic_DNA.
DR EMBL; AY312831; AAQ67645.1; -; Genomic_DNA.
DR EMBL; AY312832; AAQ67646.1; -; Genomic_DNA.
DR EMBL; AY312833; AAQ67647.1; -; Genomic_DNA.
DR EMBL; AY312834; AAQ67648.1; -; Genomic_DNA.
DR EMBL; AY312835; AAQ67649.1; -; Genomic_DNA.
DR EMBL; AY312836; AAQ67650.1; -; Genomic_DNA.
DR EMBL; AY312837; AAQ67651.1; -; Genomic_DNA.
DR EMBL; AY312838; AAQ67652.1; -; Genomic_DNA.
DR EMBL; AY312839; AAQ67653.1; -; Genomic_DNA.
DR EMBL; AY060681; AAL28229.1; ALT_INIT; mRNA.
DR PIR; S33642; S33642.
DR RefSeq; NP_524623.2; NM_079884.5.
DR BioGRID; 68628; 9.
DR IntAct; P28167; 7.
DR STRING; 7227.FBpp0088139; -.
DR iPTMnet; P28167; -.
DR PaxDb; P28167; -.
DR PRIDE; P28167; -.
DR EnsemblMetazoa; FBtr0089070; FBpp0088139; FBgn0004607.
DR GeneID; 43795; -.
DR KEGG; dme:Dmel_CG1449; -.
DR CTD; 43795; -.
DR FlyBase; FBgn0004607; zfh2.
DR VEuPathDB; VectorBase:FBgn0004607; -.
DR eggNOG; KOG1146; Eukaryota.
DR GeneTree; ENSGT00940000160537; -.
DR InParanoid; P28167; -.
DR OMA; DESKTGM; -.
DR PhylomeDB; P28167; -.
DR Reactome; R-DME-8941855; RUNX3 regulates CDKN1A transcription.
DR SignaLink; P28167; -.
DR BioGRID-ORCS; 43795; 0 hits in 3 CRISPR screens.
DR ChiTaRS; zfh2; fly.
DR GenomeRNAi; 43795; -.
DR PRO; PR:P28167; -.
DR Proteomes; UP000000803; Chromosome 4.
DR Bgee; FBgn0004607; Expressed in brain and 43 other tissues.
DR ExpressionAtlas; P28167; baseline and differential.
DR Genevisible; P28167; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0003677; F:DNA binding; TAS:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
DR GO; GO:0007399; P:nervous system development; IEP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0035220; P:wing disc development; IMP:FlyBase.
DR CDD; cd00086; homeodomain; 3.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00046; Homeodomain; 3.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00389; HOX; 3.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF46689; SSF46689; 3.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00027; HOMEOBOX_1; 2.
DR PROSITE; PS50071; HOMEOBOX_2; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..3005
FT /note="Zinc finger protein 2"
FT /id="PRO_0000047242"
FT ZN_FING 133..156
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 559..582
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 614..638
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 732..756
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 897..916
FT /note="C2H2-type 5; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 940..964
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 999..1023
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1074..1098
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1210..1233
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1341..1365
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1438..1462
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1477..1500
FT /note="C2H2-type 12; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1513..1535
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1541..1564
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT DNA_BIND 1797..1856
FT /note="Homeobox 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT DNA_BIND 2154..2213
FT /note="Homeobox 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT ZN_FING 2234..2256
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 2371..2393
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT DNA_BIND 2760..2819
FT /note="Homeobox 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 46..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1558..1581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1764..1800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2064..2089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2130..2157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2339..2368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2423..2457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2614..2639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2739..2760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2814..2839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..845
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1567..1581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1764..1799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2339..2366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2423..2437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2614..2637
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1337
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2361
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2450
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2451
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2749
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2751
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT CONFLICT 230
FT /note="V -> D (in Ref. 1; AAA29051)"
FT /evidence="ECO:0000305"
FT CONFLICT 401
FT /note="N -> H (in Ref. 1; AAA29051)"
FT /evidence="ECO:0000305"
FT CONFLICT 3001..3005
FT /note="VIGGK -> GKSFGKIQKSST (in Ref. 5)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3005 AA; 332019 MW; C3C60179AB1B2184 CRC64;
MSSFDVETFN GKIVYNLDGS AHIIATDNTN GGGSGSGQNC YGSTTNSLKN LSKDKGRGQE
EKDIEHPSQY HREQSDNKRQ EEAVDNRPGV ESLGSACYKS SPKIHSFRVV SAQDANSTCQ
DQIRAFKIQK PILMCFICKL SFGNVKSFSL HANTEHRLNL EELDQQLLNR EYSSAIIQRN
MDEKPQISFL QPLANNDASA DTNDTEKLQT ATEGSDATLP SSPQPVFRNV SELEPENKQE
TEQNRLLNQD REQEPESDQH TSSSKMAAPS AYIPLSSPKV AGKLTVKFGS LNSATAKTNN
LSKVSSTSSP PSTYASGEVL SPSTDNISNH KSTHCNQETE PPSSSSSEVE MKIGSMSTSP
QTNDSDVPCS GFLQMQHMTT GGAYTPQVSS FHASLAALAA NESNDNRVKL ITEFLQQQLQ
QHQSSLFPSP CPDHPDLNGV DCKTCELLDI QQRSKSPSSS HHQFSQSLPQ LQIQSQPQQT
PHRSPCSNSV ALPVSPSASS VASVGNASTA TSSFTIGACS EHINGRPQGV DCARCEMLLN
SARLNSGVQM STRNSCKTLK CPQCNWHYKY QETLEIHMRE KHPDGESACG YCLAGQQHPR
LARGESYSCG YKPYRCEICN YSTTTKGNLS IHMQSDKHLN NMQELNSSQN MVAAAAAAAV
TGKLLLSSSS PQVTAACPSN SGSGAGSGSS NIVGGTASLS GNATPSVTGA NSSNANAGSN
TNNAGTKPKP SFRCDICSYD TSVARNLRIH MTSEKHTHNM AVLQNNIKHI QAFNFLQQQQ
QSGTGNIASH SSGSFMPEVA LADLAYNQAL MIQLLHQQQQ HQQSANTKLS PSSSPVSTPD
QFSFSPKPIK LNHGTGAAMG IGMAMGMGMS HSNEVSCELS GDPHPLTKTD KWPMAFYSCL
VCDCYSTNNL DDLNQHLLLD RSRQSSSASS EIMVIHNNNY ICRLCNYKTN LKANFQLHSK
TDKHLQKLNF INHIREGGPQ NEYKMQYQQQ QLAANVVQLK CNCCDFHTNS IQKLSLHTQQ
MRHDTMRMIF QHLLYIVQQS EMHNKSSGSA EDDPQCACPD EDQQLQLQSS KKLLLCQLCN
FTAQNIHEMV QHVKGIRHLQ VEQFICLQRR SENQEIPALN EVFKVTEWVM ENEDVSLAPG
LNLARTTTND ATTDASYAAA SSAAVPAIPD VSMFSPTSPS SCATSCDKNL SQIVLPNVNN
LGSGVPTTVF KCNLCEYFVQ SKSEIAAHIE TEHSCAESDE FITIPTNTAA LQAFQTAVAA
AALAAVHQRC AVINPPTQDT VDEDKDLDTN VSDGPVGIKQ ERLEQEVDRT TSMDVTKDLA
SQATDFGAPE SPKVAETEVG VQCPLCLENH FREKQYLEDH LTSVHSVTRD GLSRLLLLVD
QKALKKESTD IACPTDKAPY ANTNALERAP TPIENTCNVS LIKSTSANPS QSVSLQGLSC
QQCEASFKHE EQLLKHAQQN QHFSLQNGEY LCLAASHISR PCFMTFRTIP TMISHFQDLH
MSLIISERHV YKYRCKQCSL AFKTQEKLTT HMLYHSMRDA TKCSFCQRNF RSTQALQKHM
EQAHAEDGTP STRTNSPQTP MLSTEETHKH LLAESHAVER EVSGSDVSPI ELETHLNKET
RHLSPTPMSL DSQSHQKHLA TFAALLKQQQ CNSDAGGLHP EALSMSTGEM PPQLQGLQNL
QHIQQHFGAV AAAAGLPINP VDMLNIMQFH HLMSLNFMNL APPLVFGANA AGNAVSGPSA
LNNSITTSTA TSASGLGDTH LTSGVSSIPV DSGKATAVPP QTQLNANANS QQLASNQKRA
RTRITDDQLK ILRAHFDINN SPSEESIMEM SQKANLPMKV VKHWFRNTLF KERQRNKDSP
YNFNNPPSTT LNLEEYERTG QAKVTPLNDT CSVAVTGPMT SSTISLPPSG NINLSSKENA
TSKVLAAGKA NASGPVTFSA TVPVSTPLSR PESTNSSGNI SDYIGNNIFF GQLGSKEQIL
PYSLDGQIKS EPQDDMIGAT DFAYQTKQHS SFSFLKQQQD LVDPPEQCLT NQNADTAQDQ
SLLAGSSLAS NCQSQQQINI FETKSESGSS DVLSRPPSPN SGAAGNVYGS MNDLLNQQLE
NMGSNMGPPK KMQIVGKTFE KNVAPMVTSG SVSTQFESNS SNSSSSSSST SGGKRANRTR
FTDYQIKVLQ EFFENNSYPK DSDLEYLSKL LLLSPRVIVV WFQNARQKQR KIYENQPNNT
LFENEETKKQ NINYACKKCN LVFQRYYELI RHQKNHCFKE ENNKKSAKAQ IAAAQIAQNL
SSEDSNSSMD IHHVGICPPG SAVASHTLST PGSAAPLPGQ YTQHSFGALP SPQHLFAKSS
SLTDFSPSTT PTPPQRERSN SLDQIQRPPK FDCDKCELNF NQLEKLREHQ LLHLMNPGNI
CSDVGQNSNP EANFGPFGSI LQSLQQAAAQ QQQQHHQQPP TKKRKYSDCS SNADEMQSLS
ELEASQKKHE YLYKYFMQNE TSQEVKQQFL MQQQQKKLEQ GNECDFELDF LTNFYQQNEL
KKVSNYDFLL QYYRTHEEAK SSQQHTFSSS KKPTIEFLLQ YYQLNESKKF FQLVASPQII
PDVPGYKPSL RIPKSTSDEA PYIGETSLEQ ATELQREKQD EQLRIDRPSE ENDLSMNKNK
VENINNNNIN VDQSNLTETN GGVPSVETKE ECTQESSLIA MDDENKYLCT RSKQKDDKEK
SHYLHNLEDF LDATMIENNS QTLTFNDDEK ACQKDELTQN SNAIEKRSSV SPVNVSSKQN
KRLRTTILPE QLNFLYECYQ SESNPSRKML EEISKKVNLK KRVVQVWFQN SRAKDKKSRN
QRHYAHISDD NSYDGSSGKE VYSDLRSNGI TVDTDLETNL QDCQLCQVTQ VNIRKHAFSV
EHISKMKKLL EQTTELYAQS NGSGSEDNDS DREKRFYNLS KAFLLQHVVT NATSHAIHTA
RQDSDVIAEG NCILNYDTNG GDSKSHVQHN LPNEVVSEDA RKIAGNQELM QQLFNRNHIT
VIGGK
