ZFHX2_HUMAN
ID ZFHX2_HUMAN Reviewed; 2572 AA.
AC Q9C0A1; Q9UPU6;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 3.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Zinc finger homeobox protein 2;
DE AltName: Full=Zinc finger homeodomain protein 2;
DE Short=ZFH-2;
GN Name=ZFHX2; Synonyms=KIAA1056, KIAA1762, ZNF409;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1113-2572 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11214970; DOI=10.1093/dnares/7.6.347;
RA Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:347-355(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, INVOLVEMENT IN MARSIS, AND VARIANT MARSIS
RP LYS-1913.
RX PubMed=29253101; DOI=10.1093/brain/awx326;
RA Habib A.M., Matsuyama A., Okorokov A.L., Santana-Varela S., Bras J.T.,
RA Aloisi A.M., Emery E.C., Bogdanov Y.D., Follenfant M., Gossage S.J.,
RA Gras M., Humphrey J., Kolesnikov A., Le Cann K., Li S., Minett M.S.,
RA Pereira V., Ponsolles C., Sikandar S., Torres J.M., Yamaoka K., Zhao J.,
RA Komine Y., Yamamori T., Maniatis N., Panov K.I., Houlden H., Ramirez J.D.,
RA Bennett D.L.H., Marsili L., Bachiocco V., Wood J.N., Cox J.J.;
RT "A novel human pain insensitivity disorder caused by a point mutation in
RT ZFHX2.";
RL Brain 141:365-376(2018).
CC -!- FUNCTION: Transcriptional regulator that is critical for the regulation
CC of pain perception and processing of noxious stimuli.
CC {ECO:0000269|PubMed:29253101}.
CC -!- INTERACTION:
CC Q9C0A1; O15354: GPR37; NbExp=3; IntAct=EBI-25850811, EBI-15639515;
CC Q9C0A1; P28799-2: GRN; NbExp=3; IntAct=EBI-25850811, EBI-25860013;
CC Q9C0A1; P10636: MAPT; NbExp=3; IntAct=EBI-25850811, EBI-366182;
CC Q9C0A1; P10636-6: MAPT; NbExp=3; IntAct=EBI-25850811, EBI-7796455;
CC Q9C0A1; D3DTS7: PMP22; NbExp=3; IntAct=EBI-25850811, EBI-25882629;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29253101}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9C0A1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9C0A1-2; Sequence=VSP_039496, VSP_039497;
CC -!- DISEASE: Marsili syndrome (MARSIS) [MIM:147430]: An autosomal dominant
CC disorder characterized by congenital pain insensitivity. Painless
CC cutaneous thermal burns and bone fractures are present in affected
CC individuals. Corneal reflex is absent, sweating is decreased or absent.
CC Patients have normal cognitive abilities, and display no evidence of
CC distal weakness. {ECO:0000269|PubMed:29253101}. Note=The disease may be
CC caused by variants affecting the gene represented in this entry.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA83008.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB028979; BAA83008.2; ALT_INIT; mRNA.
DR EMBL; AB051549; BAB21853.1; -; mRNA.
DR EMBL; AL132855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL135999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS55907.1; -. [Q9C0A1-1]
DR RefSeq; NP_207646.2; NM_033400.2. [Q9C0A1-1]
DR RefSeq; XP_011535547.1; XM_011537245.2. [Q9C0A1-1]
DR RefSeq; XP_011535548.1; XM_011537246.2. [Q9C0A1-1]
DR RefSeq; XP_011535549.1; XM_011537247.2. [Q9C0A1-1]
DR RefSeq; XP_016877203.1; XM_017021714.1. [Q9C0A1-1]
DR AlphaFoldDB; Q9C0A1; -.
DR BioGRID; 124533; 6.
DR IntAct; Q9C0A1; 7.
DR STRING; 9606.ENSP00000413418; -.
DR iPTMnet; Q9C0A1; -.
DR PhosphoSitePlus; Q9C0A1; -.
DR BioMuta; ZFHX2; -.
DR DMDM; 300669698; -.
DR EPD; Q9C0A1; -.
DR jPOST; Q9C0A1; -.
DR MassIVE; Q9C0A1; -.
DR PaxDb; Q9C0A1; -.
DR PeptideAtlas; Q9C0A1; -.
DR PRIDE; Q9C0A1; -.
DR ProteomicsDB; 79976; -. [Q9C0A1-1]
DR ProteomicsDB; 79977; -. [Q9C0A1-2]
DR Antibodypedia; 51729; 42 antibodies from 13 providers.
DR DNASU; 85446; -.
DR Ensembl; ENST00000419474.5; ENSP00000413418.2; ENSG00000136367.15. [Q9C0A1-1]
DR GeneID; 85446; -.
DR KEGG; hsa:85446; -.
DR MANE-Select; ENST00000419474.5; ENSP00000413418.2; NM_033400.3; NP_207646.2.
DR UCSC; uc010tno.2; human. [Q9C0A1-1]
DR CTD; 85446; -.
DR DisGeNET; 85446; -.
DR GeneCards; ZFHX2; -.
DR HGNC; HGNC:20152; ZFHX2.
DR HPA; ENSG00000136367; Tissue enhanced (brain, testis).
DR MalaCards; ZFHX2; -.
DR MIM; 147430; phenotype.
DR MIM; 617828; gene.
DR neXtProt; NX_Q9C0A1; -.
DR OpenTargets; ENSG00000136367; -.
DR VEuPathDB; HostDB:ENSG00000136367; -.
DR eggNOG; KOG1146; Eukaryota.
DR GeneTree; ENSGT00940000160537; -.
DR HOGENOM; CLU_001401_1_0_1; -.
DR InParanoid; Q9C0A1; -.
DR OMA; PDTHLPQ; -.
DR OrthoDB; 15351at2759; -.
DR PhylomeDB; Q9C0A1; -.
DR TreeFam; TF323288; -.
DR PathwayCommons; Q9C0A1; -.
DR SignaLink; Q9C0A1; -.
DR BioGRID-ORCS; 85446; 16 hits in 1072 CRISPR screens.
DR ChiTaRS; ZFHX2; human.
DR GenomeRNAi; 85446; -.
DR Pharos; Q9C0A1; Tdark.
DR PRO; PR:Q9C0A1; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9C0A1; protein.
DR Bgee; ENSG00000136367; Expressed in buccal mucosa cell and 127 other tissues.
DR ExpressionAtlas; Q9C0A1; baseline and differential.
DR Genevisible; Q9C0A1; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030534; P:adult behavior; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
DR GO; GO:0051930; P:regulation of sensory perception of pain; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 3.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR027028; ZFHX2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45891:SF1; PTHR45891:SF1; 1.
DR Pfam; PF00046; Homeodomain; 3.
DR SMART; SM00389; HOX; 3.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SMART; SM00451; ZnF_U1; 7.
DR SUPFAM; SSF46689; SSF46689; 3.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; Disease variant; DNA-binding; Homeobox;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..2572
FT /note="Zinc finger homeobox protein 2"
FT /id="PRO_0000047243"
FT ZN_FING 453..476
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 508..532
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 821..845
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 870..894
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1009..1032
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1191..1217
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1248..1272
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1480..1503
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT DNA_BIND 1595..1654
FT /note="Homeobox 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT ZN_FING 1670..1696
FT /note="C2H2-type 9; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1769..1791
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT DNA_BIND 1857..1916
FT /note="Homeobox 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT DNA_BIND 2065..2124
FT /note="Homeobox 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT ZN_FING 2451..2471
FT /note="C2H2-type 11; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 2495..2519
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 929..974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1269..1325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1389..1408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1415..1434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1528..1591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1696..1769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1820..1860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1912..2065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2268..2327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2398..2431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2551..2572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..627
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..968
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1095..1109
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1116..1138
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1275..1308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1389..1403
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1529..1553
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1561..1581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1697..1725
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1983..2007
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2024..2040
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2281..2296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2400..2423
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2558..2572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 854..862
FT /note="FLLDMEGAE -> RTETGLLIK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11214970"
FT /id="VSP_039496"
FT VAR_SEQ 863..2572
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11214970"
FT /id="VSP_039497"
FT VARIANT 1913
FT /note="R -> K (in MARSIS; dbSNP:rs1555344723)"
FT /evidence="ECO:0000269|PubMed:29253101"
FT /id="VAR_081116"
FT CONFLICT 473
FT /note="R -> Q (in Ref. 1; BAA83008)"
FT /evidence="ECO:0000305"
FT CONFLICT 550
FT /note="P -> T (in Ref. 1; BAA83008)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2572 AA; 274176 MW; 239C8050F65B25C2 CRC64;
MATLNSASTT GTTPSPGHNA PSLPSDTFSS STPSDPVTKD PPAASSTSEN MRSSEPGGQL
LESGCGLVPP KEIGEPQEGP DCGHFPPNDP GVEKDKEQEE EEEGLPPMDL SNHLFFTAGG
EAYLVAKLSL PGGSELLLPK GFPWGEAGIK EEPSLPFLAY PPPSHLTALH IQHGFDPIQG
FSSSDQILSH DTSAPSPAAC EERHGAFWSY QLAPNPPGDP KDGPMGNSGG NHVAVFWLCL
LCRLGFSKPQ AFMDHTQSHG VKLTPAQYQG LSGSPAVLQE GDEGCKALIS FLEPKLPARP
SSDIPLDNSS TVNMEANVAQ TEDGPPEAEV QALILLDEEV MALSPPSPPT ATWDPSPTQA
KESPVAAGEA GPDWFPEGQE EDGGLCPPLN QSSPTSKEGG TLPAPVGSPE DPSDPPQPYR
LADDYTPAPA AFQGLSLSSH MSLLHSRNSC KTLKCPKCNW HYKYQQTLDV HMREKHPESN
SHCSYCSAGG AHPRLARGES YNCGYKPYRC DVCNYSTTTK GNLSIHMQSD KHLANLQGFQ
AGPGGQGSPP EASLPPSAGD KEPKTKSSWQ CKVCSYETNI SRNLRIHMTS EKHMQNVLML
HQGLPLGLPP GLMGPGPPPP PGATPTSPPE LFQYFGPQAL GQPQTPLAGP GLRPDKPLEA
QLLLNGFHHV GAPARKFPTS APGSLSPDAH LPPSQLLGSS SDSLPTSPPP DDSLSLKVFR
CLVCQAFSTD SLELLLYHCS IGRSLPEAEW KEVAGDTHRC KLCCYGTQLK ANFQLHLKTD
KHAQKYQLAA HLREGGGAMG TPSPASLGDG APYGSVSPLH LRCNICDFES NSKEKMQLHA
RGAAHEENSQ IYKFLLDMEG AEAGAELGLY HCLLCAWETP SRLAVLQHLR TPAHRDAQAQ
RRLQLLQNGP TTEEGLAALQ SILSFSHGQL RTPGKAPVTP LAEPPTPEKD AQNKTEQLAS
EETENKTGPS RDSANQTTVY CCPYCSFLSP ESSQVRAHTL SQHAVQPKYR CPLCQEQLVG
RPALHFHLSH LHNVVPECVE KLLLVATTVE MTFTTKVLSA PTLSPLDNGQ EPPTHGPEPT
PSRDQAAEGP NLTPEASPDP LPEPPLASVE VPDKPSGSPG QPPSPAPSPV PEPDAQAEDV
APPPTMAEEE EGTTGELRSA EPAPADSRHP LTYRKTTNFA LDKFLDPARP YKCTVCKESF
TQKNILLVHY NSVSHLHKMK KAAIDPSAPA RGEAGAPPTT TAATDKPFKC TVCRVSYNQS
STLEIHMRSV LHQTRSRGTK TDSKIEGPER SQEEPKEGET EGEVGTEKKG PDTSGFISGL
PFLSPPPPPL DLHRFPAPLF TPPVLPPFPL VPESLLKLQQ QQLLLPFYLH DLKVGPKLTL
AGPAPVLSLP AATPPPPPQP PKAELAEREW ERPPMAKEGN EAGPSSPPDP LPNEAARTAA
KALLENFGFE LVIQYNEGKQ AVPPPPTPPP PEALGGGDKL ACGACGKLFS NMLILKTHEE
HVHRRFLPFE ALSRYAAQFR KSYDSLYPPL AEPPKPPDGS LDSPVPHLGP PFLVPEPEAG
GTRAPEERSR AGGHWPIEEE ESSRGNLPPL VPAGRRFSRT KFTEFQTQAL QSFFETSAYP
KDGEVERLAS LLGLASRVVV VWFQNARQKA RKNACEGGSM PTGGGTGGAS GCRRCHATFS
CVFELVRHLK KCYDDQTLEE EEEEAERGEE EEEVEEEEVE EEQGLEPPAG PEGPLPEPPD
GEELSQAEAT KAGGKEPEEK ATPSPSPAHT CDQCAISFSS QDLLTSHRRL HFLPSLQPSA
PPQLLDLPLL VFGERNPLVA ATSPMPGPPL KRKHEDGSLS PTGSEAGGGG EGEPPRDKRL
RTTILPEQLE ILYRWYMQDS NPTRKMLDCI SEEVGLKKRV VQVWFQNTRA RERKGQFRST
PGGVPSPAVK PPATATPASL PKFNLLLGKV DDGTGREAPK REAPAFPYPT ATLASGPQPF
LPPGKEATTP TPEPPLPLLP PPPPSEEEGP EEPPKASPES EACSLSAGDL SDSSASSLAE
PESPGAGGTS GGPGGGTGVP DGMGQRRYRT QMSSLQLKIM KACYEAYRTP TMQECEVLGE
EIGLPKRVIQ VWFQNARAKE KKAKLQGTAA GSTGGSSEGL LAAQRTDCPY CDVKYDFYVS
CRGHLFSRQH LAKLKEAVRA QLKSESKCYD LAPAPEAPPA LKAPPATTPA SMPLGAAPTL
PRLAPVLLSG PALAQPPLGN LAPFNSGPAA SSGLLGLATS VLPTTTVVQT AGPGRPLPQR
PMPDQTNTST AGTTDPVPGP PTEPLGDKVS SERKPVAGPT SSSNDALKNL KALKTTVPAL
LGGQFLPFPL PPAGGTAPPA VFGPQLQGAY FQQLYGMKKG LFPMNPMIPQ TLIGLLPNAL
LQPPPQPPEP TATAPPKPPE LPAPGEGEAG EVDELLTGST GISTVDVTHR YLCRQCKMAF
DGEAPATAHQ RSFCFFGRGS GGSMPPPLRV PICTYHCLAC EVLLSGREAL ASHLRSSAHR
RKAAPPQGGP PISITNAATA ASAAVAFAKE EARLPHTDSN PKTTTTSTLL AL
