ZFHX2_MOUSE
ID ZFHX2_MOUSE Reviewed; 2562 AA.
AC Q2MHN3; Q5DU04; Q80VJ9;
DT 28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Zinc finger homeobox protein 2;
DE AltName: Full=Zinc finger homeodomain protein 5 {ECO:0000303|PubMed:16257534};
GN Name=Zfhx2 {ECO:0000312|MGI:MGI:2686934};
GN Synonyms=Kiaa1056 {ECO:0000312|EMBL:BAD90426.1},
GN zfh-5 {ECO:0000303|PubMed:16257534};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
RN [1] {ECO:0000312|EMBL:BAE78491.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP INDUCTION.
RC STRAIN=C57BL/6Cr {ECO:0000312|EMBL:BAE78491.1};
RC TISSUE=Brain {ECO:0000312|EMBL:BAE78491.1};
RX PubMed=16257534; DOI=10.1016/j.mcn.2005.09.017;
RA Komine Y., Nakamura K., Katsuki M., Yamamori T.;
RT "Novel transcription factor zfh-5 is negatively regulated by its own
RT antisense RNA in mouse brain.";
RL Mol. Cell. Neurosci. 31:273-283(2006).
RN [2] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000312|EMBL:BAD90426.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-222.
RC TISSUE=Brain {ECO:0000312|EMBL:BAD90426.1};
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAH50052.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2155-2562.
RC STRAIN=FVB/N {ECO:0000312|EMBL:AAH50052.1};
RC TISSUE=Mammary tumor {ECO:0000312|EMBL:AAH50052.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5] {ECO:0000305}
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=23300874; DOI=10.1371/journal.pone.0053114;
RA Komine Y., Takao K., Miyakawa T., Yamamori T.;
RT "Behavioral abnormalities observed in Zfhx2-deficient mice.";
RL PLoS ONE 7:E53114-E53114(2012).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE,
RP AND MUTAGENESIS OF ARG-1907.
RX PubMed=29253101; DOI=10.1093/brain/awx326;
RA Habib A.M., Matsuyama A., Okorokov A.L., Santana-Varela S., Bras J.T.,
RA Aloisi A.M., Emery E.C., Bogdanov Y.D., Follenfant M., Gossage S.J.,
RA Gras M., Humphrey J., Kolesnikov A., Le Cann K., Li S., Minett M.S.,
RA Pereira V., Ponsolles C., Sikandar S., Torres J.M., Yamaoka K., Zhao J.,
RA Komine Y., Yamamori T., Maniatis N., Panov K.I., Houlden H., Ramirez J.D.,
RA Bennett D.L.H., Marsili L., Bachiocco V., Wood J.N., Cox J.J.;
RT "A novel human pain insensitivity disorder caused by a point mutation in
RT ZFHX2.";
RL Brain 141:365-376(2018).
CC -!- FUNCTION: Transcriptional regulator that is critical for the regulation
CC of pain perception and processing of noxious stimuli.
CC {ECO:0000269|PubMed:29253101}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29253101}.
CC -!- TISSUE SPECIFICITY: Expressed in brain (at protein level)
CC (PubMed:23300874). Expressed at the highest levels in the pyramidal
CC cell layer of the hippocampus, the suprachiasmatic nucleus,
CC laterodorsal thalamic nucleus, lateral geniculate nucleus, substantia
CC nigra pars compacta, and magnocellular part of the red nucleus (at
CC protein level) (PubMed:23300874). Highly expressed in dorsal root
CC ganglia (PubMed:29253101). Expressed at lower levels in kidney,
CC stomach, liver, heart and testis (PubMed:16257534, PubMed:23300874).
CC {ECO:0000269|PubMed:16257534, ECO:0000269|PubMed:23300874,
CC ECO:0000269|PubMed:29253101}.
CC -!- DEVELOPMENTAL STAGE: Detected at 11.5 days post coitum (dpc) in
CC developing brain, and continues to be expressed all the way through to
CC postnatal day 21 (PubMed:23300874). In brain, expressed at 13.5 dpc in
CC thalamus, hypothalamus, midbrain and pontine area (PubMed:16257534).
CC {ECO:0000269|PubMed:16257534, ECO:0000269|PubMed:23300874}.
CC -!- INDUCTION: Expression in specific regions of the developing brain is
CC negatively regulated by its antisense mRNA. In particular, down-
CC regulated in pyramidal and granule cells in the hippocampus during
CC early differentiation and the migration stage.
CC {ECO:0000269|PubMed:16257534}.
CC -!- DISRUPTION PHENOTYPE: Knockout mice exhibit a range of subtle
CC behavioral abnormalities. Locomotor activity is generally increased,
CC but only in familiar environments. There is a slight increase in
CC depression-like behavior, most notably increased immobility in the tail
CC suspension test. Assays of anxiety-like behavior give conflicting
CC results; the open field test indicates a slight reduction in anxiety-
CC like behavior whereas other tests show no significant behavioral
CC changes (PubMed:23300874). Knockout mice are hyposensitive to noxious
CC mechanical stimuli applied to the tail and hypersensitive to noxious
CC heat (PubMed:29253101). {ECO:0000269|PubMed:23300874,
CC ECO:0000269|PubMed:29253101}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD90426.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB190186; BAE78491.1; -; mRNA.
DR EMBL; AC157212; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK220366; BAD90426.1; ALT_INIT; mRNA.
DR EMBL; BC050052; AAH50052.1; -; mRNA.
DR CCDS; CCDS27107.1; -.
DR RefSeq; NP_001034287.1; NM_001039198.1.
DR RefSeq; XP_006519044.1; XM_006518981.3.
DR AlphaFoldDB; Q2MHN3; -.
DR STRING; 10090.ENSMUSP00000045156; -.
DR iPTMnet; Q2MHN3; -.
DR PhosphoSitePlus; Q2MHN3; -.
DR MaxQB; Q2MHN3; -.
DR PaxDb; Q2MHN3; -.
DR PeptideAtlas; Q2MHN3; -.
DR PRIDE; Q2MHN3; -.
DR ProteomicsDB; 275145; -.
DR Antibodypedia; 51729; 42 antibodies from 13 providers.
DR Ensembl; ENSMUST00000036328; ENSMUSP00000045156; ENSMUSG00000040721.
DR GeneID; 239102; -.
DR KEGG; mmu:239102; -.
DR UCSC; uc007txz.1; mouse.
DR CTD; 85446; -.
DR MGI; MGI:2686934; Zfhx2.
DR VEuPathDB; HostDB:ENSMUSG00000040721; -.
DR eggNOG; KOG1146; Eukaryota.
DR GeneTree; ENSGT00940000160537; -.
DR HOGENOM; CLU_001401_1_0_1; -.
DR InParanoid; Q2MHN3; -.
DR OMA; PDTHLPQ; -.
DR OrthoDB; 15351at2759; -.
DR PhylomeDB; Q2MHN3; -.
DR TreeFam; TF323288; -.
DR BioGRID-ORCS; 239102; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Zfhx2; mouse.
DR PRO; PR:Q2MHN3; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q2MHN3; protein.
DR Bgee; ENSMUSG00000040721; Expressed in embryonic brain and 121 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030534; P:adult behavior; IMP:MGI.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
DR GO; GO:0051930; P:regulation of sensory perception of pain; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 3.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR027028; ZFHX2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45891:SF1; PTHR45891:SF1; 1.
DR Pfam; PF00046; Homeodomain; 3.
DR SMART; SM00389; HOX; 3.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SMART; SM00451; ZnF_U1; 7.
DR SUPFAM; SSF46689; SSF46689; 3.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..2562
FT /note="Zinc finger homeobox protein 2"
FT /id="PRO_0000443288"
FT ZN_FING 446..469
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 501..525
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 752..776
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 815..839
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 864..888
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1003..1026
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1185..1211
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1242..1266
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1474..1497
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT DNA_BIND 1589..1648
FT /note="Homeobox 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT ZN_FING 1664..1687
FT /note="C2H2-type 10; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1761..1783
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT DNA_BIND 1851..1910
FT /note="Homeobox 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT DNA_BIND 2058..2117
FT /note="Homeobox 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT ZN_FING 2441..2461
FT /note="C2H2-type 12; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 2485..2509
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1058..1126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1140..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1278..1313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1520..1584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1689..1760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1814..1853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1907..1934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1971..2057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2114..2136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2186..2210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2263..2313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2391..2429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2506..2525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2540..2562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..621
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..952
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1278..1302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1521..1546
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1692..1715
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1734..1751
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1971..2000
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2012..2033
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2273..2290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2398..2412
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2548..2562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 1907
FT /note="R->K: Results in hyposensitivity to noxious heat."
FT /evidence="ECO:0000269|PubMed:29253101"
FT CONFLICT 13
FT /note="V -> I (in Ref. 3; BAD90426)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2562 AA; 273485 MW; 71B4EA2972A84F81 CRC64;
MATLNSASPS GTVPSPGHNV RSPPPETSSS STSDPVTKDP PDAPSTSESI RSSEPGGERL
ESGSDLDPPK EIGEPQEEPG CGHIPPKDLG VAKEEEEILP LDLSSHLFFA AGGQAYLLAN
LPLPRGSELS LPKGFPWDEA SAKEEPSLPL LTHFPSSHLT TLHIQHGFDP IQGFSSSDQM
LSHDTSAPSL AACERRDGSF WSYQLVPNPT EDPKDGPLGS RREDHRAMFW ICLLCRLGFG
RLQTFIGHTL SHGVKLSPAH HQGLLGSPAV LQEGHDGGMA LLSFLEPKFL TRPSPEVPDT
STVTVKTNGA QAEDGPPEAD GQALVLPAEE VIALSPPSPP TALATWDPSP TQAKDSPVPR
GEAGPDWFPE GQEEDGGLCL PLNQSSPTSK EVAVLPAPAG SPEDTSDPPP SCRLADDYTP
APAAFQGLSL SSHMSLLHSR NSCKTLKCPK CNWHYKYQQT LDVHMREKHP ESNSHCSYCS
AGGAHPRLAR GESYNCGYKP YRCDVCNYST TTKGNLSIHM QSDKHLANLQ GFQAGPGGQA
SPPEASLPPT SVGDKEPKTK SSWQCKVCSY ETNISRNLRI HMTSEKHMQN VLMLHQGLPL
GLPPGLVGPG PPPPPGAAPT NPPELFQYFG PQALGQPQTP MPGPGLRPDK PLEAQLLLNG
FHHLGAPARK FPTAAPGSLS PETHLPPSQL LGSSSDGLPT SPSPDDSPAL KVFRCLVCQA
FSTDSLELLL YHCSIGRSLP EAEWKEVAGD THRCKLCCYG TQLKANFQLH LKTDKHTQKY
QLAAHLREGG GAMGTPSLLA LGDGASYGSI SPLHLRCNIC DFESNSKEKM QLHTRGSAHE
ENSQIYKFLL EMEGAEAGPE PGLYHCLLCA WDTPSRLALL QHLRTPAHRD AQAQRRLQLL
QNGPAAEEGL SALQSILSFS HGRLQTPGKA SDTPLAQPPT SEKDAQNKTE QQASEVTEDR
SGPPRDSANQ ITVFCCPYCS FLSPECDQVR VHTLSQHAVQ PKYRCPLCQE QLVGRPALHF
HLSHLHNVVP ECVEKLLLVA TTVEMTFATK MLPGPTLNPV EDGLDHPAPG AEPTPNRDQV
AESSNLAPEV SPDPPLEPPL APVEGSREPS ESPDQPPSPA PSPAPRLDAQ VEELAPLPTM
SEEEEGAMGE PRSAEPTPAD SRHPLTYRKT TNFALDKFLD PARPYKCTVC KESFTQKNIL
LVHYNSVSHL HKMKKAAIDP SGPARGEAGI PPPAATASDK PFKCTVCRVS YNQSSTLEIH
MRSVLHQTRS RGAKIDARAE GAERGQEEFK EGETEGEAGT EKKGPDPGGF MSGLPFLSPP
PPPLDLHRFS APLFTPPVLP PFPLVPESLL KLQQQQLLLP FYLHDLKVGP KLALASPTPM
LSLPAANPPP LPAPPKAELA EQEWERPLMA EEGTEAGPSS PTHTSPNEAA RTAAKALLEN
FGFELVIQYN EGKQAVPPPP TPPPPESLGG GDKLACGACG KLFSNMLILK THEEHVHRRF
LPFEALSRYA AQFRKSYDSL YPPPVEPPKP PDGCLESPPQ LGPPFVVPEP EVGGIHTSEE
RSLSGGGPWP SEEEEGSRGS LPPAVPVGRR FSRTKFTEFQ TQALQSFFET SAYPKDGEVE
RLASLLGLAS RVVVVWFQNA RQKARKNACE GGPVTAGGAS GGASGCRRCH ATFACVFELV
RHLKKCYDDQ PPEEEEEAER GEEEEEVEEE EAEERNLEPA AARPGGPSPE HADGEDLSQT
EPTRPESKES EGKAPPSPPV YACDQCAASF PSQDLLTTHH RLHLLPSVQP SAPPPSQLLD
LPLLVFGERN PVVSGTSSVT GTPLKRKHDD GSLSPTGSEA GGGGEGEPPK DKRLRTTILP
EQLEILYRWY MQDSNPTRKM LDCISEEVGL KKRVVQVWFQ NTRARERKGQ FRSTPGGVAG
PAVKPTVPPS PAPFPKFNLL LSKIEDETGK EAPKRDAPAF PYPTVTPAVG PLPFLPPGKE
AAVPTPEPPP PLPPPALSED EGPEEPSKAS PESEACSPSA GDLSDSSASS LAEPESPGAG
GTSGGPGGGT GVPDSMGQRR YRTQMSSLQL KIMKACYEAY RTPTMQECEV LGEEIGLPKR
VIQVWFQNAR AKEKKAKLQG TAPPGSGGSS EGTSAAQRTD CPYCDVKYDF YVSCRGHLFS
RQHLAKLKEA VRAQLKSESK CYDLAPAPET PLAPKGPPAT TPASSVPLGA SPTLPRLAPV
LLPGPTLAQP PLGSIASFNS GPAASSGLLG LATSVLPATT VVQTAGPGRP LPQRPVSNQT
NSSTDPTPGP ATEPSGDKVS GERKPVATLP NSSTDALKNL KALKATVPAL LGGQFLPFPL
PPAGGAAPPA VFGPQLQGAY FQQLYGMKKG LFPMNPVIPQ TLIGLLPNAL LQQPPQAPEP
TATAPPKPPE LPASGEGESS EADELLTGST GISTVDVTHR YLCRQCKMAF DGEAPATAHQ
RSFCFFGRGS GASMPAPLRV PICTYHCLAC EVLLSGREAL ASHLRSSAHR RKAAPPPGGP
PITVTNSATA VPAAVAFAKE EARLPHTDPN PKTTTTSTLL AL
