CC175_HUMAN
ID CC175_HUMAN Reviewed; 793 AA.
AC P0C221; G3V5J7;
DT 14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 14-MAY-2014, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Coiled-coil domain-containing protein 175;
GN Name=CCDC175; Synonyms=C14orf38;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
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DR EMBL; AL121694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS53898.1; -.
DR RefSeq; NP_001157871.1; NM_001164399.1.
DR AlphaFoldDB; P0C221; -.
DR SMR; P0C221; -.
DR BioGRID; 610063; 4.
DR STRING; 9606.ENSP00000453940; -.
DR iPTMnet; P0C221; -.
DR PhosphoSitePlus; P0C221; -.
DR BioMuta; CCDC175; -.
DR DMDM; 117940155; -.
DR EPD; P0C221; -.
DR jPOST; P0C221; -.
DR MassIVE; P0C221; -.
DR PaxDb; P0C221; -.
DR PeptideAtlas; P0C221; -.
DR PRIDE; P0C221; -.
DR ProteomicsDB; 33544; -.
DR ProteomicsDB; 52300; -.
DR Antibodypedia; 100; 8 antibodies from 7 providers.
DR DNASU; 729665; -.
DR Ensembl; ENST00000537690.7; ENSP00000453940.1; ENSG00000151838.12.
DR GeneID; 729665; -.
DR KEGG; hsa:729665; -.
DR MANE-Select; ENST00000537690.7; ENSP00000453940.1; NM_001164399.2; NP_001157871.1.
DR UCSC; uc021rtw.2; human.
DR CTD; 729665; -.
DR DisGeNET; 729665; -.
DR GeneCards; CCDC175; -.
DR HGNC; HGNC:19847; CCDC175.
DR HPA; ENSG00000151838; Tissue enriched (brain).
DR neXtProt; NX_P0C221; -.
DR OpenTargets; ENSG00000151838; -.
DR VEuPathDB; HostDB:ENSG00000151838; -.
DR eggNOG; ENOG502RXX0; Eukaryota.
DR GeneTree; ENSGT00390000001277; -.
DR InParanoid; P0C221; -.
DR OrthoDB; 1137420at2759; -.
DR TreeFam; TF351236; -.
DR PathwayCommons; P0C221; -.
DR BioGRID-ORCS; 729665; 12 hits in 1068 CRISPR screens.
DR ChiTaRS; CCDC175; human.
DR GenomeRNAi; 729665; -.
DR Pharos; P0C221; Tdark.
DR PRO; PR:P0C221; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; P0C221; protein.
DR Bgee; ENSG00000151838; Expressed in cerebellar cortex and 67 other tissues.
DR ExpressionAtlas; P0C221; baseline and differential.
DR InterPro; IPR038834; CCDC175.
DR PANTHER; PTHR35347; PTHR35347; 1.
PE 4: Predicted;
KW Coiled coil; Reference proteome.
FT CHAIN 1..793
FT /note="Coiled-coil domain-containing protein 175"
FT /id="PRO_0000259927"
FT COILED 131..163
FT /evidence="ECO:0000255"
FT COILED 205..377
FT /evidence="ECO:0000255"
FT COILED 431..535
FT /evidence="ECO:0000255"
FT COILED 562..679
FT /evidence="ECO:0000255"
FT COILED 716..745
FT /evidence="ECO:0000255"
FT VARIANT 164
FT /note="G -> R (in dbSNP:rs17834244)"
FT /id="VAR_050871"
FT VARIANT 507
FT /note="G -> E (in dbSNP:rs4261431)"
FT /id="VAR_050872"
FT VARIANT 689
FT /note="S -> N (in dbSNP:rs12887189)"
FT /id="VAR_050873"
FT VARIANT 689
FT /note="S -> R (in dbSNP:rs4394993)"
FT /id="VAR_050874"
SQ SEQUENCE 793 AA; 93626 MW; 550A4313A3FB487F CRC64;
MALSPWTPGL GAGEKLVQAA AVSTGPSLEL CTLPSTLGSS VAVEALEQLF VVEQSLQSDY
FKCNEEAKIF LKDIAVAVKK LEEMRKATID LLEIESMELN KLYYLLETLP NSIKRELEEC
VRDARRLNLF EINTIKMRIT RTENEIELLK KKITDLTKYN EALGEKQEEL ARKHARFVLS
LNQTMEKKAT TTVYINETYT KINLKREDIA LQKKCIQEAE ELMEKERAEY LIRKQELTAQ
INEFENTREV KRMETYQKKK ELDKLQTKMS KIKETVTVSA AVLSDHNLEI ARLHESIRYW
EQEVSELKKD LAILEAKLCF FTDNKEKLDD ISNDEKNEFL NKIKQLVETL HAARMEYKDL
REKMKTLARQ YKIVLSEEEK AFLQKQKIHD ENQKQLTFIS QKEYFLSQKR VDIKNMEEGL
ITLQELQQAT KTVYQQQIKI LSANLERESQ RCVITQWKMA CLRKKHARWT AKIKAEIQAI
TEKIQNAEVR RIELLNETSF RQQEISGFVA QIEKLTTELK EEEKAFVNKE KMLMKELSKY
EEIFVKETQI NKEKEEELVE YLPQLQVAEQ EYKEKRRKLE ELSNIITAQR QEEDLLNNHI
FLFTRDFSRY ISNMEDVKQE LQQLRDQESK KNKDHFETLK NLENGFYIND QKADLLLLEN
KKLKEYILYL KNNIEKYREG QEALMHTSSD LSRQLIAQEA QYKDLWAEFQ TTVKILVDNG
EETLQDINNL TDKLRERDEK MQHVSTWLRG SLEGLRLLVE QESPMDLLKK KKHIRTRVHF
PVVKCTEKNT LTK
