ZFN2A_HUMAN
ID ZFN2A_HUMAN Reviewed; 145 AA.
AC Q8N6M9; A4D220;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=AN1-type zinc finger protein 2A;
GN Name=ZFAND2A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-53.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N6M9; Q15038: DAZAP2; NbExp=3; IntAct=EBI-3921109, EBI-724310;
CC Q8N6M9; Q96CS7: PLEKHB2; NbExp=3; IntAct=EBI-3921109, EBI-373552;
CC Q8N6M9; Q9NWF9: RNF216; NbExp=3; IntAct=EBI-3921109, EBI-723313;
CC Q8N6M9; P36406: TRIM23; NbExp=3; IntAct=EBI-3921109, EBI-740098;
CC Q8N6M9; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-3921109, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR EMBL; CH236953; EAL23939.1; -; Genomic_DNA.
DR EMBL; CH471144; EAW87196.1; -; Genomic_DNA.
DR EMBL; BC029558; AAH29558.1; -; mRNA.
DR CCDS; CCDS5323.1; -.
DR RefSeq; NP_872297.2; NM_182491.2.
DR AlphaFoldDB; Q8N6M9; -.
DR SMR; Q8N6M9; -.
DR BioGRID; 124747; 27.
DR IntAct; Q8N6M9; 6.
DR STRING; 9606.ENSP00000314619; -.
DR iPTMnet; Q8N6M9; -.
DR PhosphoSitePlus; Q8N6M9; -.
DR BioMuta; ZFAND2A; -.
DR DMDM; 229462785; -.
DR MassIVE; Q8N6M9; -.
DR MaxQB; Q8N6M9; -.
DR PaxDb; Q8N6M9; -.
DR PeptideAtlas; Q8N6M9; -.
DR PRIDE; Q8N6M9; -.
DR ProteomicsDB; 72201; -.
DR Antibodypedia; 10898; 106 antibodies from 16 providers.
DR DNASU; 90637; -.
DR Ensembl; ENST00000316495.8; ENSP00000314619.3; ENSG00000178381.12.
DR GeneID; 90637; -.
DR KEGG; hsa:90637; -.
DR MANE-Select; ENST00000316495.8; ENSP00000314619.3; NM_182491.4; NP_872297.2.
DR UCSC; uc003skc.4; human.
DR CTD; 90637; -.
DR DisGeNET; 90637; -.
DR GeneCards; ZFAND2A; -.
DR HGNC; HGNC:28073; ZFAND2A.
DR HPA; ENSG00000178381; Low tissue specificity.
DR MIM; 610699; gene.
DR neXtProt; NX_Q8N6M9; -.
DR OpenTargets; ENSG00000178381; -.
DR PharmGKB; PA142670526; -.
DR VEuPathDB; HostDB:ENSG00000178381; -.
DR eggNOG; KOG3183; Eukaryota.
DR GeneTree; ENSGT00940000161571; -.
DR HOGENOM; CLU_061621_3_0_1; -.
DR InParanoid; Q8N6M9; -.
DR OMA; DFLPYIC; -.
DR PhylomeDB; Q8N6M9; -.
DR TreeFam; TF314219; -.
DR PathwayCommons; Q8N6M9; -.
DR SignaLink; Q8N6M9; -.
DR BioGRID-ORCS; 90637; 11 hits in 1080 CRISPR screens.
DR ChiTaRS; ZFAND2A; human.
DR GenomeRNAi; 90637; -.
DR Pharos; Q8N6M9; Tbio.
DR PRO; PR:Q8N6M9; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8N6M9; protein.
DR Bgee; ENSG00000178381; Expressed in oocyte and 178 other tissues.
DR ExpressionAtlas; Q8N6M9; baseline and differential.
DR Genevisible; Q8N6M9; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000502; C:proteasome complex; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0071243; P:cellular response to arsenic-containing substance; IEA:Ensembl.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0045047; P:protein targeting to ER; IBA:GO_Central.
DR Gene3D; 4.10.1110.10; -; 2.
DR InterPro; IPR035896; AN1-like_Znf.
DR InterPro; IPR000058; Znf_AN1.
DR Pfam; PF01428; zf-AN1; 2.
DR SMART; SM00154; ZnF_AN1; 2.
DR SUPFAM; SSF118310; SSF118310; 2.
DR PROSITE; PS51039; ZF_AN1; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..145
FT /note="AN1-type zinc finger protein 2A"
FT /id="PRO_0000269888"
FT ZN_FING 4..52
FT /note="AN1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT ZN_FING 94..142
FT /note="AN1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 10
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 15
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 25
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 28
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 33
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 36
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 42
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 44
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 100
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 105
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 115
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 118
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 123
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 126
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 132
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT BINDING 134
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00449"
FT VARIANT 53
FT /note="H -> L (in dbSNP:rs17855544)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_055295"
SQ SEQUENCE 145 AA; 16477 MW; 7726D71465B4D44C CRC64;
MEFPDLGKHC SEKTCKQLDF LPVKCDACKQ DFCKDHFPYA AHKCPFAFQK DVHVPVCPLC
NTPIPVKKGQ IPDVVVGDHI DRDCDSHPGK KKEKIFTYRC SKEGCKKKEM LQMVCAQCHG
NFCIQHRHPL DHSCRHGSRP TIKAG
