ZFP11_MOUSE
ID ZFP11_MOUSE Reviewed; 647 AA.
AC P10751; B2RTF0; P10752; P10753; Q505E4; Q6PDR5; Q8BSI2; Q8C3R5;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 2.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Zinc finger protein 11;
DE Short=Zfp-11;
DE AltName: Full=Zinc finger protein Krox-6.1A/6.1B+/6.1B-;
GN Name=Zfp11; Synonyms=Krox-6.1a, Krox-6.1b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Lung, and Wolffian duct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, Eye, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 472-582.
RX PubMed=2452975; DOI=10.1128/mcb.8.3.1319-1326.1988;
RA Chavrier P., Lemaire P., Revelant O., Bravo R., Charnay P.;
RT "Characterization of a mouse multigene family that encodes zinc finger
RT structures.";
RL Mol. Cell. Biol. 8:1319-1326(1988).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH58553.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC28063.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK032872; BAC28063.1; ALT_FRAME; mRNA.
DR EMBL; AK085077; BAC39356.1; -; mRNA.
DR EMBL; BC058553; AAH58553.1; ALT_INIT; mRNA.
DR EMBL; BC094590; AAH94590.2; -; mRNA.
DR EMBL; BC139312; AAI39313.1; -; mRNA.
DR EMBL; BC139315; AAI39316.1; -; mRNA.
DR EMBL; M20755; AAA39385.1; -; Genomic_DNA.
DR EMBL; M20756; AAA39386.1; -; Genomic_DNA.
DR EMBL; M20757; AAA39387.1; -; Genomic_DNA.
DR CCDS; CCDS39291.1; -.
DR PIR; B29942; B29942.
DR PIR; C29942; C29942.
DR PIR; D29942; D29942.
DR RefSeq; NP_766050.1; NM_172462.4.
DR AlphaFoldDB; P10751; -.
DR SMR; P10751; -.
DR BioGRID; 204635; 1.
DR IntAct; P10751; 1.
DR STRING; 10090.ENSMUSP00000051861; -.
DR iPTMnet; P10751; -.
DR PhosphoSitePlus; P10751; -.
DR PaxDb; P10751; -.
DR PRIDE; P10751; -.
DR ProteomicsDB; 275350; -.
DR Antibodypedia; 47728; 87 antibodies from 13 providers.
DR DNASU; 22648; -.
DR Ensembl; ENSMUST00000049778; ENSMUSP00000051861; ENSMUSG00000051034.
DR GeneID; 22648; -.
DR KEGG; mmu:22648; -.
DR UCSC; uc008zta.1; mouse.
DR CTD; 22648; -.
DR MGI; MGI:99156; Zfp11.
DR VEuPathDB; HostDB:ENSMUSG00000051034; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163308; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; P10751; -.
DR OMA; CGKAYYF; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P10751; -.
DR TreeFam; TF343410; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 22648; 1 hit in 64 CRISPR screens.
DR PRO; PR:P10751; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; P10751; protein.
DR Bgee; ENSMUSG00000051034; Expressed in superior cervical ganglion and 191 other tissues.
DR Genevisible; P10751; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 19.
DR SMART; SM00355; ZnF_C2H2; 21.
DR SUPFAM; SSF57667; SSF57667; 11.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 21.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 21.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..647
FT /note="Zinc finger protein 11"
FT /id="PRO_0000047283"
FT ZN_FING 57..79
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 85..107
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 113..135
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 141..163
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 169..191
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 197..219
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 225..247
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 253..275
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 281..303
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 309..331
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 337..359
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 365..387
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 393..415
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 421..443
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 449..471
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 477..499
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 505..527
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 533..555
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 561..583
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 589..611
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 617..639
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 71
FT /note="V -> L (in Ref. 1; BAC28063)"
FT /evidence="ECO:0000305"
FT CONFLICT 526..528
FT /note="IHT -> SIP (in Ref. 3; AAA39386)"
FT /evidence="ECO:0000305"
FT CONFLICT 580
FT /note="Q -> R (in Ref. 3; AAA39386)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 647 AA; 75605 MW; 19FF9F00C4168CD1 CRC64;
MSPENLSDCN NSVKDFDQHP ELTIRQCVHR EKPYKQEECD DSACDQHLRV HKGGMPYECK
DCGKAFKYRS VLYQHRIIHT AARPYKCKEC GKAFKRSRNL AQHQVTHKRE KPHKCEECGR
AFSALSVLTQ HRITHTGEKP FKCKECGRAF KYNSTLTQHE VIHTEAKPYR CQECGKAFKR
SHTLSQHQVI HKGEKPHKCD ECGRAFSKHS SLTQHQVIHT GEKPYQCREC GKAFRYQSTL
TRHHIVHTGA KPYKCPECDK AFNNSSTLSR HQIIHTGEKP YKCQECGRAF YCSSFLIQHM
KIHFEEMPYR CRECGKPFRL SSQLIRHQRI HTGEEPYICR ECGKTFKYQS NLTRHQILHT
GAKPYKCPEC GKAFNNSSTL TRHQIIHTGE KPYKCQECSK AFYCSSYLIQ HMKIHFEEIP
YRCKECGKPF KCSSQLIRHQ RIHSGEKPYI CKECGKAFNC TSYLTKHQRI HTGEKPYVCQ
ECGKAFNCSS YLSKHQRIHI GDRLYKCKEC GKAYYFSSQL NRHQRIHTGE KPYVCQECGK
AFNCSSYLTK HQRIHIVEKP YVCKECSKAF SCSSYLTKHQ RIHAGDRLYK CTECGKAYCF
SSQLNRHQRI HTRERPYRCK ECGKAFITSS CLKRHQETHT LQTPNSV
