ZFP14_MOUSE
ID ZFP14_MOUSE Reviewed; 501 AA.
AC P10755; Q5DTW6; Q8BFZ5;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Zinc finger protein 14;
DE Short=Zfp-14;
DE AltName: Full=Zinc finger protein Krox-9;
GN Name=Zfp14; Synonyms=Kiaa1559, Krox-9, Zfp-14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Olfactory bulb, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal brain;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 381-467.
RX PubMed=2452975; DOI=10.1128/mcb.8.3.1319-1326.1988;
RA Chavrier P., Lemaire P., Revelant O., Bravo R., Charnay P.;
RT "Characterization of a mouse multigene family that encodes zinc finger
RT structures.";
RL Mol. Cell. Biol. 8:1319-1326(1988).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD90454.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK028663; BAC26053.1; -; mRNA.
DR EMBL; AK032214; BAC27763.1; -; mRNA.
DR EMBL; AK220404; BAD90454.1; ALT_INIT; mRNA.
DR EMBL; BC066057; AAH66057.1; -; mRNA.
DR EMBL; M20758; AAA39389.1; -; Genomic_DNA.
DR CCDS; CCDS39875.1; -.
DR PIR; F29942; F29942.
DR RefSeq; NP_035878.1; NM_011748.2.
DR RefSeq; NP_848848.1; NM_178733.5.
DR RefSeq; XP_006540012.1; XM_006539949.3.
DR RefSeq; XP_017177726.1; XM_017322237.1.
DR AlphaFoldDB; P10755; -.
DR SMR; P10755; -.
DR STRING; 10090.ENSMUSP00000076960; -.
DR iPTMnet; P10755; -.
DR PhosphoSitePlus; P10755; -.
DR EPD; P10755; -.
DR MaxQB; P10755; -.
DR PaxDb; P10755; -.
DR PRIDE; P10755; -.
DR Antibodypedia; 29750; 90 antibodies from 17 providers.
DR DNASU; 243906; -.
DR Ensembl; ENSMUST00000077787; ENSMUSP00000076960; ENSMUSG00000053985.
DR Ensembl; ENSMUST00000207072; ENSMUSP00000146913; ENSMUSG00000053985.
DR Ensembl; ENSMUST00000207873; ENSMUSP00000146824; ENSMUSG00000053985.
DR GeneID; 243906; -.
DR KEGG; mmu:243906; -.
DR UCSC; uc009gcw.1; mouse.
DR CTD; 57677; -.
DR MGI; MGI:99160; Zfp14.
DR VEuPathDB; HostDB:ENSMUSG00000053985; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162016; -.
DR HOGENOM; CLU_002678_0_9_1; -.
DR InParanoid; P10755; -.
DR OMA; YECVECW; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P10755; -.
DR TreeFam; TF341817; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 243906; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Zfp14; mouse.
DR PRO; PR:P10755; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P10755; protein.
DR Bgee; ENSMUSG00000053985; Expressed in cortical plate and 149 other tissues.
DR Genevisible; P10755; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001835; P:blastocyst hatching; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..501
FT /note="Zinc finger protein 14"
FT /id="PRO_0000047286"
FT DOMAIN 8..80
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 140..162
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 168..190
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 196..218
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 224..246
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 252..274
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 280..302
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 308..330
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 336..358
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 364..386
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 392..414
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 420..442
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 448..470
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 476..498
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 136
FT /note="G -> E (in Ref. 2; BAD90454)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 501 AA; 59060 MW; DAD07022035A22F5 CRC64;
MALAQGLVTF GDVAVDFSQE EWEFLDPAQK NLYRDVMWET YSNFISLDLE SRFKTDTSSS
DKGICEVYSL QWELIEKIKN LSPQGSGLSD DQECKHKTGL QKEPQEGYFG QLKITSEKVT
YEKHSFLSEY QRVQNGEKFY ECKECRKTFI RRSTLSQHLR IHTGEKPYKC KECGQPFRQR
AHLIRHHKLH TGEKPYECKD CGKAFTVLQE LTQHQRLHTG EKPYECKECG KAFRVHQQLA
RHQRIHTGEK PYECKECGKT FRQCTHLTRH QRLHTSEKLY ECKECGKAFV CGPDLRVHQK
IHFGEKPYAC KDCGKSFRIC QQLTVHQSIH TGEKPYECKE CGKTFRLRQQ LVRHQRIHTH
ERPYECLECW KTFSSYSQLI SHQSIHVGER PYECEECGKA FRLLSQLTQH QSIHTGEKPY
ECQECRKPFR LLSQLTQHRS IHTGEKPYEC KDCGKAFRLY SFLSQHQRIH TGEKPYKCKE
CKKAFRQHSH LTQHQKIHSG T
