ZFP26_MOUSE
ID ZFP26_MOUSE Reviewed; 861 AA.
AC P10076; Q3UR72; Q5DTI1;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 166.
DE RecName: Full=Zinc finger protein 26;
DE Short=Zfp-26;
DE AltName: Full=Protein mKR3;
GN Name=Zfp26; Synonyms=Kiaa4196, Mkr3, Zfp-26;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 425-861.
RC TISSUE=Fetal brain;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 433-861.
RX PubMed=3143103; DOI=10.1093/nar/16.21.9995;
RA Chowdhury K., Rohdewohld H., Gruss P.;
RT "Specific and ubiquitous expression of different Zn finger protein genes in
RT the mouse.";
RL Nucleic Acids Res. 16:9995-10011(1988).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK141740; BAE24816.1; -; mRNA.
DR EMBL; AK220539; BAD90314.1; -; mRNA.
DR EMBL; M36514; AAA37118.1; -; mRNA.
DR EMBL; X12592; CAA31105.1; -; mRNA.
DR PIR; S03677; S03677.
DR RefSeq; NP_035883.2; NM_011753.3.
DR AlphaFoldDB; P10076; -.
DR SMR; P10076; -.
DR STRING; 10090.ENSMUSP00000124075; -.
DR iPTMnet; P10076; -.
DR PhosphoSitePlus; P10076; -.
DR MaxQB; P10076; -.
DR PaxDb; P10076; -.
DR PRIDE; P10076; -.
DR ProteomicsDB; 275352; -.
DR DNASU; 22688; -.
DR GeneID; 22688; -.
DR KEGG; mmu:22688; -.
DR UCSC; uc009oil.2; mouse.
DR CTD; 22688; -.
DR MGI; MGI:99173; Zfp26.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; P10076; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P10076; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 22688; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Zfp26; mouse.
DR PRO; PR:P10076; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P10076; protein.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 19.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 23.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 13.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 22.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 23.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..861
FT /note="Zinc finger protein 26"
FT /id="PRO_0000047287"
FT DOMAIN 9..80
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 191..213
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 246..268
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 274..296
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 302..324
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 330..352
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 358..380
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 386..408
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 414..436
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 442..464
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 470..492
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 498..520
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 526..548
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 554..576
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 582..604
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 610..632
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 638..660
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 666..688
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 694..716
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 722..744
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 750..772
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 778..800
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 806..828
FT /note="C2H2-type 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 834..856
FT /note="C2H2-type 23; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 460
FT /note="H -> N (in Ref. 3; CAA31105/AAA37118)"
FT /evidence="ECO:0000305"
FT CONFLICT 476
FT /note="G -> W (in Ref. 3; CAA31105/AAA37118)"
FT /evidence="ECO:0000305"
FT CONFLICT 536
FT /note="A -> V (in Ref. 3; CAA31105/AAA37118)"
FT /evidence="ECO:0000305"
FT CONFLICT 616
FT /note="G -> D (in Ref. 3; CAA31105/AAA37118)"
FT /evidence="ECO:0000305"
FT CONFLICT 681
FT /note="L -> P (in Ref. 3; CAA31105/AAA37118)"
FT /evidence="ECO:0000305"
FT CONFLICT 732
FT /note="A -> P (in Ref. 3; CAA31105/AAA37118)"
FT /evidence="ECO:0000305"
FT CONFLICT 751
FT /note="Q -> R (in Ref. 3; CAA31105/AAA37118)"
FT /evidence="ECO:0000305"
FT CONFLICT 775..776
FT /note="EK -> GR (in Ref. 3; CAA31105/AAA37118)"
FT /evidence="ECO:0000305"
FT CONFLICT 779
FT /note="Q -> R (in Ref. 3; CAA31105/AAA37118)"
FT /evidence="ECO:0000305"
FT CONFLICT 785
FT /note="K -> R (in Ref. 3; CAA31105/AAA37118)"
FT /evidence="ECO:0000305"
FT CONFLICT 859..860
FT /note="EN -> DL (in Ref. 3; CAA31105/AAA37118)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 861 AA; 97989 MW; 24E87864BCCD83A1 CRC64;
METQQVDAVT FEDVAVDFTQ EEWTSLDPVQ RNLYRDVMLE NYQNLATVGG QMFKPSLISW
LEKKVELTVI EQGILQEWEM HLKTKRTALQ QDRFWSDMSN GMQLGREHSG GEPGDPVQVG
AVFSEDSCPQ THSSTSNTGN TFACNLDGKD FQPLLKETST EENIVQLNQC VKPLIFTPDV
SQKKCTPEKS VECSDCGETF VNQLELQTHS SSHREKNIHK SEECGQASTH PISHGGHVIP
TEKKYYECKK CEKFFTHPVY LNIHMQSHTV EKPYDCKECG KAFTERSSLI VHLRQHTREK
SYECKECGKT FIQPSRLTEH MRSHTGEKPY QCDQCGNAFA SSSYLTTHLR THTGEKPFEC
NICGKAFTRS SYLLGHIRTH TGEKPYECKV CGKAFSGRSW LTIHLRKHTG ERPYPCTECE
KAFTSFAQLT EHIKTHTGEK PFRCKVCART FRNSSCLKTH FRIHTGIKPY KCNYCGKAFT
ARSGLTKHVL IHNGEKPYEC KECGKAFSTS SGLVEHIRIH TGEKPFECYQ CGKALAHSSS
LVGHLRTHTG EKPFECNQCD KTFTRSSYLR IHMRTHTGEK PYECKECGKT FPERSCLTKH
IRTHTGERPY ECKECGKGFI SFAQLTVHIK THSSERPFQC KVCTKSFRNS SSLETHFRIH
TGVKPYKCSY CGKAFTARSG LTIHLRNHTG EKSYACQECG KAFSTSSGLI AHIRSHKGEK
PFECDHCGKA FASSSYLNVH LKIHTGEKPF QCTVCGKTFT CSSYLPVHMR THTGEKPFQC
IICGKSFLWS SYLRVHMRIH TGEKPYVCQY CGKAFTEHSG LNKHLRKHTG EKPYEYKECG
ENFTTSADAN EHETPHWGEN L
