ZFP27_MOUSE
ID ZFP27_MOUSE Reviewed; 819 AA.
AC P10077; Q6PCZ6; Q8CED4;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 2.
DT 03-AUG-2022, entry version 183.
DE RecName: Full=Zinc finger protein 27;
DE Short=Zfp-27;
DE AltName: Full=Protein mKR4;
GN Name=Zfp27; Synonyms=Mkr4, Zfp-27;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Skin, and Wolffian duct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 240-686 (ISOFORM 2).
RX PubMed=3143103; DOI=10.1093/nar/16.21.9995;
RA Chowdhury K., Rohdewohld H., Gruss P.;
RT "Specific and ubiquitous expression of different Zn finger protein genes in
RT the mouse.";
RL Nucleic Acids Res. 16:9995-10011(1988).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P10077-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P10077-2; Sequence=VSP_016025;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA31106.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK028500; BAC25981.1; -; mRNA.
DR EMBL; AK135293; BAE22479.1; -; mRNA.
DR EMBL; AK147732; BAE28102.1; -; mRNA.
DR EMBL; BC059037; AAH59037.1; -; mRNA.
DR EMBL; M36515; AAA37119.1; ALT_FRAME; mRNA.
DR EMBL; X12593; CAA31106.1; ALT_FRAME; mRNA.
DR CCDS; CCDS21076.1; -. [P10077-1]
DR PIR; S03678; S03678.
DR RefSeq; NP_001032796.1; NM_001037707.1. [P10077-1]
DR RefSeq; NP_001272726.1; NM_001285797.1. [P10077-1]
DR RefSeq; NP_001272727.1; NM_001285798.1. [P10077-1]
DR RefSeq; NP_035884.2; NM_011754.2. [P10077-1]
DR RefSeq; XP_011248783.1; XM_011250481.2. [P10077-1]
DR RefSeq; XP_011248784.1; XM_011250482.2. [P10077-1]
DR RefSeq; XP_017177621.1; XM_017322132.1. [P10077-1]
DR AlphaFoldDB; P10077; -.
DR SMR; P10077; -.
DR BioGRID; 204653; 25.
DR STRING; 10090.ENSMUSP00000123953; -.
DR iPTMnet; P10077; -.
DR PhosphoSitePlus; P10077; -.
DR PaxDb; P10077; -.
DR PRIDE; P10077; -.
DR DNASU; 22689; -.
DR Ensembl; ENSMUST00000053521; ENSMUSP00000054012; ENSMUSG00000062040. [P10077-1]
DR Ensembl; ENSMUST00000159920; ENSMUSP00000125232; ENSMUSG00000062040. [P10077-1]
DR Ensembl; ENSMUST00000161904; ENSMUSP00000124684; ENSMUSG00000062040. [P10077-1]
DR Ensembl; ENSMUST00000162592; ENSMUSP00000123953; ENSMUSG00000062040. [P10077-1]
DR Ensembl; ENSMUST00000172448; ENSMUSP00000127677; ENSMUSG00000062040. [P10077-1]
DR GeneID; 22689; -.
DR KEGG; mmu:22689; -.
DR UCSC; uc009gcl.1; mouse. [P10077-1]
DR CTD; 22689; -.
DR MGI; MGI:99174; Zfp27.
DR VEuPathDB; HostDB:ENSMUSG00000062040; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000166306; -.
DR HOGENOM; CLU_002678_17_1_1; -.
DR InParanoid; P10077; -.
DR OMA; HEYKDIR; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P10077; -.
DR TreeFam; TF343410; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 22689; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Zfp27; mouse.
DR PRO; PR:P10077; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P10077; protein.
DR Bgee; ENSMUSG00000062040; Expressed in ureteric bud trunk and 168 other tissues.
DR Genevisible; P10077; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 19.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 21.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 12.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 21.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 22.
PE 2: Evidence at transcript level;
KW Alternative splicing; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..819
FT /note="Zinc finger protein 27"
FT /id="PRO_0000047288"
FT DOMAIN 1..75
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 205..227
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 233..255
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 261..283
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 289..311
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 317..339
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 345..367
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 401..423
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 429..451
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 457..479
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 485..507
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 513..535
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 541..563
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 569..591
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 597..619
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 625..647
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 653..675
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 681..703
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 709..731
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 737..759
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 765..787
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 793..815
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 93..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 337..364
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:3143103"
FT /id="VSP_016025"
FT CONFLICT 59
FT /note="S -> N (in Ref. 1; BAC25981)"
FT /evidence="ECO:0000305"
FT CONFLICT 555..556
FT /note="DL -> EP (in Ref. 3; AAA37119/CAA31106)"
FT /evidence="ECO:0000305"
FT CONFLICT 572..573
FT /note="ST -> RP (in Ref. 3; AAA37119/CAA31106)"
FT /evidence="ECO:0000305"
FT CONFLICT 625
FT /note="H -> Q (in Ref. 3; AAA37119/CAA31106)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 819 AA; 92894 MW; C714C5850E2AA2BB CRC64;
MDVTIDFSRE EWQHLDPAQR SLYRDVVQET YSHLRSVEEL QQIGDQKKTY QQIGHKSASD
MVFITKTLGA ESCHDYSGVR KVIHVNSYIV LPPKRPRHWD PPEDEPKHSS DLQTHDESNG
LKRTKRITEY GKISSCINTE HILTGEKLPD HNQCGKVLGY KQIPCQYQKI HTGEKSYECA
EFGKIFTQKS QLRVHVTSPT GEKLYVCVEC GKACSQTSEF LTHQKTHTRE KPYKCGDCGK
SFFQVSSLFR HRRIHTGEKL YDCSHCGKGF SYNSDLRIHQ KIHTGEKRHG CVDCGKAFTQ
KSTLRMHQKI HTGERAYVCI ECGQAFIQKT HLVAHRRIHT GEKPYACDGC GKAFLSKSQL
LVHQRIHSRV RPCVSLDRAK PFSSAPNLLP RKKVQMREKS SICAECGKAF TYRSELIIHQ
RTHTGEKPYQ CGDCGKAFTQ KSALTVHRRI HTGEKSYVCV KCGLAFVQRA HLDAHQVIHT
GEKPYQCGHC GKFFTSKSQL HVHKRIHTGE KPYVCSNCGK AFANRSNLIT HQKTHTGEKA
YVCARCGKAF TQRSDLVTHQ RIHTGEKPYG CSTCGKAFTQ KSHLSIHEKI HTGERQYGCR
DCGKAFNQKS ILIVHQKIHT GEKPHVCAEC GRAFIRKSNF ITHQRIHTGE KPYGCTDCGK
SFTSKSQLLV HRPIHTGEKP YVCAECGKAF SGRSNLSKHQ KTHTGEKPYA CSECGKSFRQ
KSELITHHRI HTGEKPYDCG DCGKSFTKKS QLQVHQRIHT GEKPYRCAEC GKAFTDRSNL
NKHQTTHTGE KPYKCVVCGK GFVQKSVLSI HENVHTSAV
