ZFP2_HUMAN
ID ZFP2_HUMAN Reviewed; 461 AA.
AC Q6ZN57; A5PLN5; B7ZM23; Q9H6Z6;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Zinc finger protein ZFP2;
DE Short=Zfp-2;
DE AltName: Full=Zinc finger protein 751;
GN Name=ZFP2; Synonyms=ZNF751;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum, and Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable transcription factor involved in neuronal
CC differentiation and/or phenotypic maintenance. {ECO:0000250}.
CC -!- INTERACTION:
CC Q6ZN57; Q7Z5W3: BCDIN3D; NbExp=3; IntAct=EBI-7236323, EBI-10257921;
CC Q6ZN57; G5E9A7: DMWD; NbExp=3; IntAct=EBI-7236323, EBI-10976677;
CC Q6ZN57; Q08379: GOLGA2; NbExp=3; IntAct=EBI-7236323, EBI-618309;
CC Q6ZN57; P42858: HTT; NbExp=12; IntAct=EBI-7236323, EBI-466029;
CC Q6ZN57; O15397: IPO8; NbExp=3; IntAct=EBI-7236323, EBI-358808;
CC Q6ZN57; Q6A162: KRT40; NbExp=6; IntAct=EBI-7236323, EBI-10171697;
CC Q6ZN57; P02545: LMNA; NbExp=3; IntAct=EBI-7236323, EBI-351935;
CC Q6ZN57; Q9NYL2-2: MAP3K20; NbExp=7; IntAct=EBI-7236323, EBI-10255081;
CC Q6ZN57; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-7236323, EBI-742948;
CC Q6ZN57; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-7236323, EBI-79165;
CC Q6ZN57; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-7236323, EBI-5235340;
CC Q6ZN57; Q8WV44: TRIM41; NbExp=6; IntAct=EBI-7236323, EBI-725997;
CC Q6ZN57; Q86WV8: TSC1; NbExp=3; IntAct=EBI-7236323, EBI-12806590;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15104.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK025281; BAB15104.1; ALT_INIT; mRNA.
DR EMBL; AK131367; BAD18518.1; -; mRNA.
DR EMBL; BC132779; AAI32780.1; -; mRNA.
DR EMBL; BC132781; AAI32782.1; -; mRNA.
DR EMBL; BC142989; AAI42990.1; -; mRNA.
DR EMBL; BC144216; AAI44217.1; -; mRNA.
DR CCDS; CCDS4440.1; -.
DR RefSeq; NP_085116.2; NM_030613.3.
DR AlphaFoldDB; Q6ZN57; -.
DR SMR; Q6ZN57; -.
DR BioGRID; 123115; 14.
DR IntAct; Q6ZN57; 17.
DR MINT; Q6ZN57; -.
DR STRING; 9606.ENSP00000354453; -.
DR iPTMnet; Q6ZN57; -.
DR PhosphoSitePlus; Q6ZN57; -.
DR BioMuta; ZFP2; -.
DR DMDM; 74758715; -.
DR jPOST; Q6ZN57; -.
DR MassIVE; Q6ZN57; -.
DR MaxQB; Q6ZN57; -.
DR PaxDb; Q6ZN57; -.
DR PeptideAtlas; Q6ZN57; -.
DR PRIDE; Q6ZN57; -.
DR ProteomicsDB; 67984; -.
DR Antibodypedia; 29457; 47 antibodies from 17 providers.
DR DNASU; 80108; -.
DR Ensembl; ENST00000361362.7; ENSP00000354453.2; ENSG00000198939.8.
DR Ensembl; ENST00000520301.5; ENSP00000430980.1; ENSG00000198939.8.
DR Ensembl; ENST00000523286.1; ENSP00000430531.1; ENSG00000198939.8.
DR GeneID; 80108; -.
DR KEGG; hsa:80108; -.
DR MANE-Select; ENST00000361362.7; ENSP00000354453.2; NM_030613.4; NP_085116.2.
DR UCSC; uc003mjn.2; human.
DR CTD; 80108; -.
DR GeneCards; ZFP2; -.
DR HGNC; HGNC:26138; ZFP2.
DR HPA; ENSG00000198939; Low tissue specificity.
DR neXtProt; NX_Q6ZN57; -.
DR OpenTargets; ENSG00000198939; -.
DR PharmGKB; PA142670528; -.
DR VEuPathDB; HostDB:ENSG00000198939; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162743; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q6ZN57; -.
DR OMA; TERRVCG; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6ZN57; -.
DR TreeFam; TF350858; -.
DR PathwayCommons; Q6ZN57; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q6ZN57; -.
DR BioGRID-ORCS; 80108; 12 hits in 1059 CRISPR screens.
DR ChiTaRS; ZFP2; human.
DR GenomeRNAi; 80108; -.
DR Pharos; Q6ZN57; Tdark.
DR PRO; PR:Q6ZN57; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q6ZN57; protein.
DR Bgee; ENSG00000198939; Expressed in cortical plate and 103 other tissues.
DR ExpressionAtlas; Q6ZN57; baseline and differential.
DR Genevisible; Q6ZN57; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..461
FT /note="Zinc finger protein ZFP2"
FT /id="PRO_0000291967"
FT ZN_FING 102..124
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 130..152
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 158..180
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 186..208
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 214..236
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 242..264
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 270..292
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 298..320
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 326..348
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 354..376
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 382..404
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 410..432
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 438..460
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 113
FT /note="Q -> H (in dbSNP:rs28678700)"
FT /id="VAR_032904"
FT VARIANT 142
FT /note="R -> G (in dbSNP:rs11956147)"
FT /id="VAR_032905"
SQ SEQUENCE 461 AA; 52740 MW; 1448D86C81C7FC22 CRC64;
MEREGIWHST LGETWEPNNW LEGQQDSHLS QVGVTHKETF TEMRVCGGNE FERCSSQDSI
LDTQQSIPMV KRPHNCNSHG EDATQNSELI KTQRMFVGKK IYECNQCSKT FSQSSSLLKH
QRIHTGEKPY KCNVCGKHFI ERSSLTVHQR IHTGEKPYKC NECGKAFSQS MNLTVHQRTH
TGEKPYQCKE CGKAFHKNSS LIQHERIHTG EKPYKCNECG KAFTQSMNLT VHQRTHTGEK
PYECNECGKA FSQSMHLIVH QRSHTGEKPY ECSQCGKAFS KSSTLTLHQR NHTGEKPYKC
NKCGKSFSQS TYLIEHQRLH SGVKPFECNE CGKAFSKNSS LTQHRRIHTG EKPYECMVCG
KHFTGRSSLT VHQVIHTGEK PYECNECGKA FSQSAYLIEH QRIHTGEKPY ECDQCGKAFI
KNSSLTVHQR THTGEKPYQC NECGKAFSRS TNLTRHQRTH T
