CC177_HUMAN
ID CC177_HUMAN Reviewed; 707 AA.
AC Q9NQR7; B2R5G1; Q2M359;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2012, sequence version 3.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Coiled-coil domain-containing protein 177;
DE AltName: Full=Myelin proteolipid protein-like protein;
GN Name=CCDC177; Synonyms=C14orf162, PLPL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Mao Y., Xie Y., Zhao W., Zhou Z., Wang W., Zhao S., Huang Y.;
RT "Cloning and analysis of a novel human myelin proteolipid protein-like
RT gene.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF86288.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAG35108.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF284217; AAF86288.1; ALT_SEQ; mRNA.
DR EMBL; AK312175; BAG35108.1; ALT_SEQ; mRNA.
DR EMBL; AL133445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC105025; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC105027; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS59245.1; -.
DR RefSeq; NP_001258436.1; NM_001271507.1.
DR AlphaFoldDB; Q9NQR7; -.
DR SMR; Q9NQR7; -.
DR IntAct; Q9NQR7; 1.
DR STRING; 9606.ENSP00000469474; -.
DR iPTMnet; Q9NQR7; -.
DR PhosphoSitePlus; Q9NQR7; -.
DR BioMuta; CCDC177; -.
DR DMDM; 425906070; -.
DR MassIVE; Q9NQR7; -.
DR PaxDb; Q9NQR7; -.
DR PeptideAtlas; Q9NQR7; -.
DR PRIDE; Q9NQR7; -.
DR DNASU; 56936; -.
DR Ensembl; ENST00000599174.3; ENSP00000469474.1; ENSG00000267909.3.
DR GeneID; 56936; -.
DR KEGG; hsa:56936; -.
DR MANE-Select; ENST00000599174.3; ENSP00000469474.1; NM_001271507.2; NP_001258436.1.
DR UCSC; uc010aqy.5; human.
DR CTD; 56936; -.
DR GeneCards; CCDC177; -.
DR HGNC; HGNC:23243; CCDC177.
DR HPA; ENSG00000267909; Group enriched (brain, retina).
DR neXtProt; NX_Q9NQR7; -.
DR OpenTargets; ENSG00000267909; -.
DR VEuPathDB; HostDB:ENSG00000267909; -.
DR eggNOG; ENOG502QVGE; Eukaryota.
DR GeneTree; ENSGT00740000115643; -.
DR HOGENOM; CLU_017921_0_0_1; -.
DR InParanoid; Q9NQR7; -.
DR OMA; DLYNFDC; -.
DR OrthoDB; 1072799at2759; -.
DR PathwayCommons; Q9NQR7; -.
DR BioGRID-ORCS; 56936; 14 hits in 1010 CRISPR screens.
DR GenomeRNAi; 56936; -.
DR Pharos; Q9NQR7; Tdark.
DR PRO; PR:Q9NQR7; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9NQR7; protein.
DR Bgee; ENSG00000267909; Expressed in secondary oocyte and 42 other tissues.
DR Genevisible; Q9NQR7; HS.
DR InterPro; IPR029090; DUF4659.
DR PANTHER; PTHR33663; PTHR33663; 1.
DR Pfam; PF15558; DUF4659; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..707
FT /note="Coiled-coil domain-containing protein 177"
FT /id="PRO_0000089954"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 364..605
FT /evidence="ECO:0000255"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..533
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..637
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 311
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3UHB8"
SQ SEQUENCE 707 AA; 79739 MW; FF43347A58CC833E CRC64;
MVDPVPEEEK AGAEPGDSGG DEAVASVPPD SQGAQEPAAS SASASASAAV PRKAEVPCAA
AEGGRREQSP LLHLDLFNFD CPEAEGSRYV LTSPRSLEAC ARCAVKPVEL LPRALADLVR
EAPGRSMRVA TGLYEAYEAE RRAKLQQCRA ERERIMREEK RRLFTPLSPA AAAAAAAAAA
SAPSAGSSSS CSSASLPASP APRAARKASP SPSSARTQPP PAGSRTGRKS HSLDSLSRRR
EGALSSESGA SSSSYSGESL RELRWPPRAS ARNSCPAGSA SSTTNAPGRP SALTLVPITG
RSFSLGDLSH SPQTAQHVER IVRQVRAERG LRGVPERDRK IAALMLARHQ EELLLLEQRA
AAHGQWELQR VHAKQRRERE EREKQRALEQ GRRAWAAQVE ERRGRRGREE REAARRRQRQ
YERSEERRRE LAERQGLLRR ERAERAARED RLRKLQQEQN LKQREEGLQE GRERAEQIRR
ERAQRAARAK QRQEGQLQRE KRELSRAERA RHEALLQGRT RQQRQEREGL RSSLEASLGR
AQENYEHLVE QRTRELRERA RREELQGRRA KEAAERKERE HQAHLEALAR AGERRLQHAT
QVAEEAVQQK ARRVGQSRLE KERAQRANKE KVERDEDCRR RELLQAIGRK LERSEQLTRE
RRSALESARS TARASFHVRE KVREETNTRS FDRMVREAQL HASLDRK
