ZFP37_MOUSE
ID ZFP37_MOUSE Reviewed; 594 AA.
AC P17141; Q62514; Q80YX7;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 21-SEP-2011, sequence version 4.
DT 03-AUG-2022, entry version 187.
DE RecName: Full=Zinc finger protein 37;
DE Short=Zfp-37;
DE AltName: Full=Male germ cell-specific zinc finger protein;
GN Name=Zfp37; Synonyms=Zfp-37;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J, CBA/C57BL, and CBA/CaJ; TISSUE=Brain;
RX PubMed=8660973; DOI=10.1006/geno.1996.0189;
RA Mazarakis N., Michalovich D., Karis A., Grosveld F., Galjart N.;
RT "Zfp-37 is a member of the KRAB zinc finger gene family and is expressed in
RT neurons of the developing and adult CNS.";
RL Genomics 33:247-257(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 42-594.
RC TISSUE=Testis;
RX PubMed=1614869; DOI=10.1093/nar/20.11.2827;
RA Burke P.S., Wolgemuth D.J.;
RT "Zfp-37, a new murine zinc finger encoding gene, is expressed in a
RT developmentally regulated pattern in the male germ line.";
RL Nucleic Acids Res. 20:2827-2834(1992).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 219-594.
RC TISSUE=Testis;
RX PubMed=2114017; DOI=10.1093/nar/18.12.3655;
RA Nelki D., Dudley K., Cunningham P., Akhavan M.;
RT "Cloning and sequencing of a zinc finger cDNA expressed in mouse testis.";
RL Nucleic Acids Res. 18:3655-3655(1990).
CC -!- FUNCTION: May have a role in regulating spermiogenesis.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in testis and brain.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA36769.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; X89264; CAA61539.1; -; mRNA.
DR EMBL; AL683829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; X64413; CAA45758.1; -; mRNA.
DR EMBL; X52533; CAA36769.1; ALT_INIT; mRNA.
DR CCDS; CCDS71400.1; -.
DR PIR; S10245; S10245.
DR PIR; S22954; S22954.
DR RefSeq; NP_001277279.1; NM_001290350.1.
DR AlphaFoldDB; P17141; -.
DR SMR; P17141; -.
DR BioGRID; 204659; 50.
DR STRING; 10090.ENSMUSP00000070463; -.
DR iPTMnet; P17141; -.
DR PhosphoSitePlus; P17141; -.
DR MaxQB; P17141; -.
DR PaxDb; P17141; -.
DR PeptideAtlas; P17141; -.
DR PRIDE; P17141; -.
DR ProteomicsDB; 275147; -.
DR Antibodypedia; 29718; 115 antibodies from 17 providers.
DR DNASU; 22696; -.
DR Ensembl; ENSMUST00000068822; ENSMUSP00000070463; ENSMUSG00000028389.
DR GeneID; 22696; -.
DR KEGG; mmu:22696; -.
DR UCSC; uc008tbw.2; mouse.
DR CTD; 7539; -.
DR MGI; MGI:99181; Zfp37.
DR VEuPathDB; HostDB:ENSMUSG00000028389; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162711; -.
DR HOGENOM; CLU_002678_0_12_1; -.
DR InParanoid; P17141; -.
DR OMA; QCGKAHS; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P17141; -.
DR TreeFam; TF350860; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 22696; 1 hit in 69 CRISPR screens.
DR PRO; PR:P17141; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; P17141; protein.
DR Bgee; ENSMUSG00000028389; Expressed in seminiferous tubule of testis and 237 other tissues.
DR ExpressionAtlas; P17141; baseline and differential.
DR Genevisible; P17141; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; TAS:MGI.
DR GO; GO:0007281; P:germ cell development; TAS:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW Nucleus; Phosphoprotein; Reference proteome; Repeat; Spermatogenesis;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..594
FT /note="Zinc finger protein 37"
FT /id="PRO_0000047294"
FT DOMAIN 3..74
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 255..277
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 283..305
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 311..324
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 339..361
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 367..389
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 395..417
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 423..445
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 451..473
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 479..501
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 507..529
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 535..557
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 563..585
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 3
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O88553"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O88553"
FT CONFLICT 101
FT /note="S -> T (in Ref. 3; CAA45758)"
FT /evidence="ECO:0000305"
FT CONFLICT 169
FT /note="D -> E (in Ref. 1; CAA61539 and 3; CAA45758)"
FT /evidence="ECO:0000305"
FT CONFLICT 300
FT /note="V -> L (in Ref. 1; CAA61539 and 4; CAA36769)"
FT /evidence="ECO:0000305"
FT CONFLICT 528
FT /note="T -> P (in Ref. 3; CAA45758)"
FT /evidence="ECO:0000305"
FT CONFLICT 533
FT /note="K -> N (in Ref. 3; CAA45758)"
FT /evidence="ECO:0000305"
FT CONFLICT 572
FT /note="F -> V (in Ref. 4; CAA36769)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 594 AA; 67226 MW; D873AEEB2547F809 CRC64;
MATSEPAESD AVRAKEWEQL EPVQRDVYKD TKLENCSNPA SMGNQDPKQD IVSVLEEEEP
SSGKGKKASP SSLKKIARPK TAGTSAKLQQ DDEHREEKQK SQSKLTKEVT LRKKSSNSKK
SSEYGLLENK SLHSKHTPSE KKLLKSSSRG KNSNQNSDSL KKKPDTANDH RKSLSHSASD
VNKDEIPTRK KCDKLPNNKL SDKGDKNQTS KKCEKVCRHS ASHTKEDKIQ TGEKRKSHCR
TPSKPEKAPG SGKPYECNHC GKVLSHKQGL LDHQRTHTGE KPYECNECGI AFSQKSHLVV
HQRTHTGEKP YECEQCGKAH GHKHALTDHL RIHTGEKPYK CNECGKTFRH SSNLMQHLRS
HTGEKPYECK ECGKSFRYNS SLTEHVRTHT GEIPYECNEC GKAFKYGSSL TKHMRIHTGE
KPFECNECGK TFSKKSHLVI HQRTHTKEKP YKCDECGKAF GHSSSLTYHM RTHTGDCPFE
CNQCGKAFKQ IEGLTQHQRV HTGEKPYECV ECGKAFSQKS HLIVHQRTHT GEKPFECYEC
GKAFNAKSQL VIHQRSHTGE KPYECIECGK AFKQNASLTK HMKIHSEEQS EEED
