ZFP39_MOUSE
ID ZFP39_MOUSE Reviewed; 718 AA.
AC Q02525; Q2YDX7; Q5NC60; Q8BL91;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Zinc finger protein 39;
DE Short=Zfp-39;
DE AltName: Full=CtFIN33;
GN Name=Zfp39; Synonyms=Zfp-39;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CD-1; TISSUE=Neural stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 295-498.
RC STRAIN=ICR; TISSUE=Spermatocyte;
RX PubMed=1397691; DOI=10.1016/0012-1606(92)90120-6;
RA Noce T., Fujiwara Y., Sezaki M., Fujimoto H., Higashinakagawa T.;
RT "Expression of a mouse zinc finger protein gene in both spermatocytes and
RT oocytes during meiosis.";
RL Dev. Biol. 153:356-367(1992).
CC -!- FUNCTION: A putative DNA-binding regulatory protein associated with
CC meiosis in spermatogenesis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Predominantly in the spermatocytes and spermatids
CC of testes.
CC -!- DEVELOPMENTAL STAGE: First detected between 2 and 3 weeks after birth,
CC in parallel with the onset and progression of meiosis.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA01479.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK045944; BAC32541.1; -; mRNA.
DR EMBL; AL662903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC108271; AAI08272.1; -; mRNA.
DR EMBL; D10629; BAA01479.1; ALT_FRAME; mRNA.
DR CCDS; CCDS24752.1; -.
DR PIR; A48827; A48827.
DR RefSeq; NP_035888.2; NM_011758.2.
DR AlphaFoldDB; Q02525; -.
DR SMR; Q02525; -.
DR STRING; 10090.ENSMUSP00000099764; -.
DR iPTMnet; Q02525; -.
DR PhosphoSitePlus; Q02525; -.
DR MaxQB; Q02525; -.
DR PaxDb; Q02525; -.
DR PRIDE; Q02525; -.
DR ProteomicsDB; 275148; -.
DR Antibodypedia; 16379; 105 antibodies from 19 providers.
DR DNASU; 22698; -.
DR Ensembl; ENSMUST00000102703; ENSMUSP00000099764; ENSMUSG00000037001.
DR GeneID; 22698; -.
DR KEGG; mmu:22698; -.
DR UCSC; uc007jcn.1; mouse.
DR CTD; 22698; -.
DR MGI; MGI:99183; Zfp39.
DR VEuPathDB; HostDB:ENSMUSG00000037001; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160177; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q02525; -.
DR OMA; AFHQKSY; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q02525; -.
DR TreeFam; TF339594; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 22698; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Zfp39; mouse.
DR PRO; PR:Q02525; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q02525; protein.
DR Bgee; ENSMUSG00000037001; Expressed in spermatid and 174 other tissues.
DR Genevisible; Q02525; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW Nucleus; Reference proteome; Repeat; Spermatogenesis; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..718
FT /note="Zinc finger protein 39"
FT /id="PRO_0000047298"
FT DOMAIN 59..130
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 298..320
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 353..375
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 409..431
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 437..459
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 465..487
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 493..515
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 521..543
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 549..571
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 577..599
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 605..627
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 633..655
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 661..683
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 689..711
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 93
FT /note="S -> R (in Ref. 3; AAI08272)"
FT /evidence="ECO:0000305"
FT CONFLICT 184
FT /note="K -> E (in Ref. 1; BAC32541)"
FT /evidence="ECO:0000305"
FT CONFLICT 207
FT /note="K -> E (in Ref. 3; AAI08272)"
FT /evidence="ECO:0000305"
FT CONFLICT 213
FT /note="I -> T (in Ref. 3; AAI08272)"
FT /evidence="ECO:0000305"
FT CONFLICT 265
FT /note="H -> L (in Ref. 3; AAI08272)"
FT /evidence="ECO:0000305"
FT CONFLICT 337
FT /note="K -> M (in Ref. 3; AAI08272 and 4; BAA01479)"
FT /evidence="ECO:0000305"
FT CONFLICT 346
FT /note="V -> A (in Ref. 3; AAI08272 and 4; BAA01479)"
FT /evidence="ECO:0000305"
FT CONFLICT 350
FT /note="V -> G (in Ref. 3; AAI08272 and 4; BAA01479)"
FT /evidence="ECO:0000305"
FT CONFLICT 353
FT /note="H -> Q (in Ref. 3; AAI08272 and 4; BAA01479)"
FT /evidence="ECO:0000305"
FT CONFLICT 386
FT /note="S -> P (in Ref. 3; AAI08272 and 4; BAA01479)"
FT /evidence="ECO:0000305"
FT CONFLICT 388
FT /note="N -> K (in Ref. 3; AAI08272)"
FT /evidence="ECO:0000305"
FT CONFLICT 412
FT /note="N -> S (in Ref. 3; AAI08272 and 4; BAA01479)"
FT /evidence="ECO:0000305"
FT CONFLICT 472..473
FT /note="KT -> N (in Ref. 4; BAA01479)"
FT /evidence="ECO:0000305"
FT CONFLICT 496
FT /note="D -> G (in Ref. 3; AAI08272 and 4; BAA01479)"
FT /evidence="ECO:0000305"
FT CONFLICT 544
FT /note="T -> R (in Ref. 3; AAI08272)"
FT /evidence="ECO:0000305"
FT CONFLICT 630
FT /note="Y -> E (in Ref. 3; AAI08272)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 718 AA; 84223 MW; 24861EFF1726681E CRC64;
MRNLQPDSVE NSLSQLPSRC LETRKRKRSY KKRPVTYSYW RRTQRNRARK HKAPVKGLVS
FEDVSVDFTW DEWQDLDDSQ RKLYRDVMLE TYSSLESLGH CITKPEVIFK LEQGAEPWRA
EDVPKQSRAD VQKITELNET SQDNEERHLW HHAITYSNKS TEEKVKLGNI VNVSSNCVSN
LTVKNGNSSG MRPVALTVWQ SVLPPNKPDD TRIGEELDAS LTSEPPIHAE HPGLYSRAPG
TGQQFQCCMQ EVTCNTKALW TKRFHIAHGS SKFGESEKVP DEVALHAQDV SWVRAETFEC
SICKKTFCTK CELMKHKKIH KGQQYYTCRD CEKTFIKESY HTDQRVHAGV GSHRCKQCEK
CFHQKNQQNV HERVPREARL WEVYQSENSF GEKPNLRRYQ RTRAGYKPYG CNLCGKAFYR
KSHLGRHQKI HTGEKPYGCE ECKKTFYHKS SLTIHQRTHT GEKPYECKKC RKTFYCKSDL
NVHHRTHTGE KPYECDECRK TFYSKSHLVI HQKVHTGDKP YECEECQKAF SRKSNLTVHQ
KTHTGEKPYE CNVCGKTFHR QSHLNMHQGT HTGQKPYQCE ECGKAFYQKS SLRRHQRNHT
GSRPYACEEC RKTFLHKSSL TVHQRSHTGY KPYSCEECRK TFYSKSHLTV HQRTHTGEKP
YECKLCKKAF HQKSYLNRHQ VTHGSEKRFE CQECRKTFYH KSSLTVHQRI HLRELLCV
