CC177_MOUSE
ID CC177_MOUSE Reviewed; 706 AA.
AC Q3UHB8; Q6NXJ5;
DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Coiled-coil domain-containing protein 177;
GN Name=Ccdc177; Synonyms=Gm1568;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT "Comprehensive identification of phosphorylation sites in postsynaptic
RT density preparations.";
RL Mol. Cell. Proteomics 5:914-922(2006).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-310, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AK147473; BAE27939.1; -; mRNA.
DR EMBL; AC134537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC067044; AAH67044.1; -; mRNA.
DR CCDS; CCDS26015.1; -.
DR RefSeq; NP_001008423.2; NM_001008423.2.
DR AlphaFoldDB; Q3UHB8; -.
DR SMR; Q3UHB8; -.
DR BioGRID; 237639; 3.
DR IntAct; Q3UHB8; 2.
DR MINT; Q3UHB8; -.
DR STRING; 10090.ENSMUSP00000072982; -.
DR iPTMnet; Q3UHB8; -.
DR PhosphoSitePlus; Q3UHB8; -.
DR SwissPalm; Q3UHB8; -.
DR jPOST; Q3UHB8; -.
DR MaxQB; Q3UHB8; -.
DR PaxDb; Q3UHB8; -.
DR PeptideAtlas; Q3UHB8; -.
DR PRIDE; Q3UHB8; -.
DR ProteomicsDB; 265295; -.
DR DNASU; 380768; -.
DR Ensembl; ENSMUST00000073251; ENSMUSP00000072982; ENSMUSG00000062961.
DR GeneID; 380768; -.
DR KEGG; mmu:380768; -.
DR UCSC; uc007obh.2; mouse.
DR CTD; 56936; -.
DR MGI; MGI:2686414; Ccdc177.
DR VEuPathDB; HostDB:ENSMUSG00000062961; -.
DR eggNOG; ENOG502QVGE; Eukaryota.
DR GeneTree; ENSGT00740000115643; -.
DR HOGENOM; CLU_017921_0_0_1; -.
DR InParanoid; Q3UHB8; -.
DR OMA; ENEERWK; -.
DR OrthoDB; 1072799at2759; -.
DR PhylomeDB; Q3UHB8; -.
DR TreeFam; TF344191; -.
DR BioGRID-ORCS; 380768; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Ccdc177; mouse.
DR PRO; PR:Q3UHB8; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q3UHB8; protein.
DR Bgee; ENSMUSG00000062961; Expressed in rostral migratory stream and 128 other tissues.
DR Genevisible; Q3UHB8; MM.
DR InterPro; IPR029090; DUF4659.
DR PANTHER; PTHR33663; PTHR33663; 1.
DR Pfam; PF15558; DUF4659; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..706
FT /note="Coiled-coil domain-containing protein 177"
FT /id="PRO_0000420411"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 360..624
FT /evidence="ECO:0000255"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..532
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..580
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 310
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 346
FT /note="A -> S (in Ref. 2; AAH67044)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 706 AA; 79857 MW; 566BCD2DB34E641C CRC64;
MVDPVPEEEK EGAEPGGSEG DEATASEPPD AQGAQQPAAS SASASAAAPR KAEVPCGAEG
GRREQSPLLH LDLFNFACPE AEGSRYVLTS PRSLEACARC AVKPVELLPR ALADLVREAP
GRSMRVATGL YEAYEAERLA KLQQCRAERE RIMREEKRRL FTPKGPAAAP ASASASASAS
ALSGGSSSSC SSSSSLPASP ASRVARRTSP SPPARSRPPP AGSRTGRKSH SLDSLSRRRD
GALSSESGAS SSSYSGESLR ELRWPPRASA RNSCPAGSAS SAPNPLGRPS ALALVPLTAR
SFSLGDLSHS PQTAQHVERI VRQVRAERGL RGVPERDRKI AALMLARHQE ERLLLEQRAA
AHGQWEQQRV RAEQRREREE REKQRALERG RRAWAAQVEE RRGRRGREER EAARRRQQQC
ERSEERRREL AERQGLLRRE RVERAARDDR LRKLQQEQNL KQREEGRQEG RERAELVRRE
RAQRAARARE RQEGQLQREK RELSRAERAR HEALLRGRVR QQQEEREGLR SSLEASLGRA
QENYEQLQEQ RARELRERAR REELQGRRAK EAAERKEREH QAHLEALARA GERRLQHAAQ
VAEEAVQQKA RRVVQTRLEK ERAQRANKEK VERDEDCRRR ELLQAIGRKL ERSEQLSRER
RSALESARST ARASFHVREK VREETNTRSF DRMVREAQLH ASLDRK
