ZFP41_HUMAN
ID ZFP41_HUMAN Reviewed; 198 AA.
AC Q8N8Y5; D3DWJ5;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Zinc finger protein 41 homolog;
DE Short=Zfp-41;
GN Name=ZFP41;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: A putative DNA-binding regulatory protein associated with
CC meiosis in spermatogenesis. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8N8Y5; A0A024R4Z4: hCG_2042749; NbExp=3; IntAct=EBI-12224489, EBI-14231181;
CC Q8N8Y5; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-12224489, EBI-10172290;
CC Q8N8Y5; Q9BRT6: LLPH; NbExp=3; IntAct=EBI-12224489, EBI-741396;
CC Q8N8Y5; P55081: MFAP1; NbExp=3; IntAct=EBI-12224489, EBI-1048159;
CC Q8N8Y5; Q9NP50: SINHCAF; NbExp=3; IntAct=EBI-12224489, EBI-741906;
CC Q8N8Y5; Q9BZL1: UBL5; NbExp=3; IntAct=EBI-12224489, EBI-607755;
CC Q8N8Y5; Q8NCK3: ZNF485; NbExp=3; IntAct=EBI-12224489, EBI-12901093;
CC Q8N8Y5; Q9BQ02; NbExp=3; IntAct=EBI-12224489, EBI-23858379;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK096024; BAC04676.1; -; mRNA.
DR EMBL; CH471162; EAW82273.1; -; Genomic_DNA.
DR EMBL; CH471162; EAW82274.1; -; Genomic_DNA.
DR EMBL; CH471162; EAW82275.1; -; Genomic_DNA.
DR EMBL; BC034608; AAH34608.1; -; mRNA.
DR CCDS; CCDS6397.2; -.
DR RefSeq; NP_001258085.2; NM_001271156.2.
DR RefSeq; NP_776193.2; NM_173832.5.
DR AlphaFoldDB; Q8N8Y5; -.
DR SMR; Q8N8Y5; -.
DR BioGRID; 130307; 59.
DR IntAct; Q8N8Y5; 42.
DR STRING; 9606.ENSP00000327427; -.
DR iPTMnet; Q8N8Y5; -.
DR PhosphoSitePlus; Q8N8Y5; -.
DR BioMuta; ZFP41; -.
DR DMDM; 74760014; -.
DR MassIVE; Q8N8Y5; -.
DR PaxDb; Q8N8Y5; -.
DR PeptideAtlas; Q8N8Y5; -.
DR PRIDE; Q8N8Y5; -.
DR ProteomicsDB; 72475; -.
DR Antibodypedia; 27860; 11 antibodies from 7 providers.
DR DNASU; 286128; -.
DR Ensembl; ENST00000330701.7; ENSP00000327427.6; ENSG00000181638.20.
DR Ensembl; ENST00000520584.6; ENSP00000430465.3; ENSG00000181638.20.
DR GeneID; 286128; -.
DR KEGG; hsa:286128; -.
DR MANE-Select; ENST00000330701.7; ENSP00000327427.6; NM_173832.6; NP_776193.3.
DR UCSC; uc003yxw.5; human.
DR CTD; 286128; -.
DR DisGeNET; 286128; -.
DR GeneCards; ZFP41; -.
DR HGNC; HGNC:26786; ZFP41.
DR HPA; ENSG00000181638; Low tissue specificity.
DR neXtProt; NX_Q8N8Y5; -.
DR OpenTargets; ENSG00000181638; -.
DR PharmGKB; PA142670529; -.
DR VEuPathDB; HostDB:ENSG00000181638; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244859; -.
DR HOGENOM; CLU_002678_2_6_1; -.
DR InParanoid; Q8N8Y5; -.
DR OMA; HKTDHVR; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8N8Y5; -.
DR TreeFam; TF337091; -.
DR PathwayCommons; Q8N8Y5; -.
DR SignaLink; Q8N8Y5; -.
DR BioGRID-ORCS; 286128; 16 hits in 1093 CRISPR screens.
DR ChiTaRS; ZFP41; human.
DR GenomeRNAi; 286128; -.
DR Pharos; Q8N8Y5; Tdark.
DR PRO; PR:Q8N8Y5; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q8N8Y5; protein.
DR Bgee; ENSG00000181638; Expressed in buccal mucosa cell and 136 other tissues.
DR Genevisible; Q8N8Y5; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW Nucleus; Reference proteome; Repeat; Spermatogenesis; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..198
FT /note="Zinc finger protein 41 homolog"
FT /id="PRO_0000296186"
FT ZN_FING 87..109
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 115..137
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 143..165
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 171..193
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 198 AA; 22806 MW; A41841AA44CCBDE1 CRC64;
MEKPAGRKKK TPTPREEADV QKSALREEKV SGDRKPPERP TVPRKPRTEP CLSPEDEEHV
FDAFDASFKD DFEGVPVFIP FQRKKPYECS ECGRIFKHKT DHIRHQRVHT GEKPFKCAQC
GKAFRHSSDV TKHQRTHTGE KPFKCGECGK AFNCGSNLLK HQKTHTGEKP YECTHCGKAF
AYSSCLIRHQ KRHPRKKP
