ZFP41_MOUSE
ID ZFP41_MOUSE Reviewed; 198 AA.
AC Q02526; Q8BSV7;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Zinc finger protein 41;
DE Short=Zfp-41;
DE AltName: Full=CtFIN92;
GN Name=Zfp41; Synonyms=Zfp-41;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pituitary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 89-193, FUNCTION, SUBCELLULAR LOCATION,
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=BTBRTF; TISSUE=Spermatocyte;
RX PubMed=1397691; DOI=10.1016/0012-1606(92)90120-6;
RA Noce T., Fujiwara Y., Sezaki M., Fujimoto H., Higashinakagawa T.;
RT "Expression of a mouse zinc finger protein gene in both spermatocytes and
RT oocytes during meiosis.";
RL Dev. Biol. 153:356-367(1992).
CC -!- FUNCTION: A putative DNA-binding regulatory protein associated with
CC meiosis in spermatogenesis. {ECO:0000269|PubMed:1397691}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1397691}.
CC -!- TISSUE SPECIFICITY: Predominantly in the spermatocytes and spermatids
CC of testes. It is also expressed in the fetus and embryonic stem cells
CC at lower levels. {ECO:0000269|PubMed:1397691}.
CC -!- DEVELOPMENTAL STAGE: Detected in the newborn testis and peaks at 3
CC weeks during the first cycle of spermatogenesis. Expressed in the fetus
CC and embryo. {ECO:0000269|PubMed:1397691}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK030420; BAC26955.1; -; mRNA.
DR EMBL; BC053927; AAH53927.1; -; mRNA.
DR EMBL; D10631; BAA01481.1; -; mRNA.
DR CCDS; CCDS37108.1; -.
DR PIR; B48827; B48827.
DR RefSeq; NP_001038183.1; NM_001044718.2.
DR RefSeq; NP_035889.1; NM_011759.3.
DR RefSeq; XP_006520957.1; XM_006520894.3.
DR RefSeq; XP_006520958.1; XM_006520895.3.
DR RefSeq; XP_006520959.1; XM_006520896.3.
DR AlphaFoldDB; Q02526; -.
DR SMR; Q02526; -.
DR STRING; 10090.ENSMUSP00000056510; -.
DR iPTMnet; Q02526; -.
DR PhosphoSitePlus; Q02526; -.
DR EPD; Q02526; -.
DR jPOST; Q02526; -.
DR MaxQB; Q02526; -.
DR PaxDb; Q02526; -.
DR PeptideAtlas; Q02526; -.
DR PRIDE; Q02526; -.
DR ProteomicsDB; 275149; -.
DR DNASU; 22701; -.
DR Ensembl; ENSMUST00000054555; ENSMUSP00000056510; ENSMUSG00000047003.
DR Ensembl; ENSMUST00000161785; ENSMUSP00000124626; ENSMUSG00000047003.
DR GeneID; 22701; -.
DR KEGG; mmu:22701; -.
DR UCSC; uc007wgx.2; mouse.
DR CTD; 286128; -.
DR MGI; MGI:99186; Zfp41.
DR VEuPathDB; HostDB:ENSMUSG00000047003; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244859; -.
DR HOGENOM; CLU_002678_2_6_1; -.
DR InParanoid; Q02526; -.
DR OMA; HKTDHVR; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q02526; -.
DR TreeFam; TF337091; -.
DR BioGRID-ORCS; 22701; 1 hit in 76 CRISPR screens.
DR ChiTaRS; Zfp41; mouse.
DR PRO; PR:Q02526; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q02526; protein.
DR Bgee; ENSMUSG00000047003; Expressed in dorsal pancreas and 185 other tissues.
DR ExpressionAtlas; Q02526; baseline and differential.
DR Genevisible; Q02526; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW Nucleus; Reference proteome; Repeat; Spermatogenesis; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..198
FT /note="Zinc finger protein 41"
FT /id="PRO_0000047299"
FT ZN_FING 87..109
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 115..137
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 143..165
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 171..193
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..46
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 198 AA; 22724 MW; BD9ACDF28A97E01F CRC64;
MEKPATRKKK SQAPKEEAGA QKATVKGEKT SKGKKATKKP RKPRRPRKEP VLSPEDEAHI
FDAFDASFKD DFEGVPVFVP FQRKKPYECG ECGRIFKHKT DHIRHQRVHT GEKPFKCDQC
GKTFRHSSDV TKHQRIHTGE KPFKCGECGK AFNCGSNLLK HQKTHTGEKP YGCEECGKSF
AYSSCLIRHR KRHPRKKH
