ZFP4_ARATH
ID ZFP4_ARATH Reviewed; 260 AA.
AC Q39263; Q0WLF4; Q9C8D2;
DT 27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-JAN-2003, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Zinc finger protein 4 {ECO:0000305};
GN Name=ZFP4 {ECO:0000303|PubMed:7599312}; OrderedLocusNames=At1g66140;
GN ORFNames=F15E12.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Landsberg erecta; TISSUE=Root;
RX PubMed=7599312; DOI=10.1007/bf00020246;
RA Tague B.W., Goodman H.M.;
RT "Characterization of a family of Arabidopsis zinc finger protein cDNAs.";
RL Plant Mol. Biol. 28:267-279(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=24808098; DOI=10.1104/pp.113.234294;
RA Joseph M.P., Papdi C., Kozma-Bognar L., Nagy I., Lopez-Carbonell M.,
RA Rigo G., Koncz C., Szabados L.;
RT "The Arabidopsis ZINC FINGER PROTEIN3 interferes with abscisic acid and
RT light signaling in seed germination and plant development.";
RL Plant Physiol. 165:1203-1220(2014).
CC -!- FUNCTION: Acts as negative regulator of abscisic acid (ABA) signaling
CC during germination and early seedling development.
CC {ECO:0000269|PubMed:24808098}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q39261}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but mutant seeds are hypersensitivite to inhibition of
CC germination by abscisic acid (ABA). {ECO:0000269|PubMed:24808098}.
CC -!- MISCELLANEOUS: Seeds over-expressing ZFP4 are insensitive to inhibition
CC of germination by abscisic acid (ABA). {ECO:0000269|PubMed:24808098}.
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DR EMBL; L39647; AAA87300.1; -; mRNA.
DR EMBL; AC026480; AAG51296.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34466.1; -; Genomic_DNA.
DR EMBL; AF361630; AAK32798.1; -; mRNA.
DR EMBL; AY058087; AAL24195.1; -; mRNA.
DR EMBL; AY056067; AAL06967.1; -; mRNA.
DR EMBL; AK230229; BAF02034.1; -; mRNA.
DR EMBL; AK230232; BAF02037.1; -; mRNA.
DR EMBL; AK230250; BAF02053.1; -; mRNA.
DR PIR; B96686; B96686.
DR PIR; S55884; S55884.
DR RefSeq; NP_176788.1; NM_105285.3.
DR AlphaFoldDB; Q39263; -.
DR BioGRID; 28149; 4.
DR STRING; 3702.AT1G66140.1; -.
DR iPTMnet; Q39263; -.
DR PaxDb; Q39263; -.
DR PRIDE; Q39263; -.
DR ProteomicsDB; 242944; -.
DR DNASU; 842928; -.
DR EnsemblPlants; AT1G66140.1; AT1G66140.1; AT1G66140.
DR GeneID; 842928; -.
DR Gramene; AT1G66140.1; AT1G66140.1; AT1G66140.
DR KEGG; ath:AT1G66140; -.
DR Araport; AT1G66140; -.
DR TAIR; locus:2013820; AT1G66140.
DR eggNOG; ENOG502QTY7; Eukaryota.
DR HOGENOM; CLU_085865_1_0_1; -.
DR InParanoid; Q39263; -.
DR OMA; DEAEMLW; -.
DR OrthoDB; 1628373at2759; -.
DR PhylomeDB; Q39263; -.
DR PRO; PR:Q39263; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q39263; baseline and differential.
DR Genevisible; Q39263; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0019760; P:glucosinolate metabolic process; IMP:TAIR.
DR GO; GO:0009788; P:negative regulation of abscisic acid-activated signaling pathway; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR InterPro; IPR045320; JAGGED/KNUCKLES-like.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45730; PTHR45730; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 2: Evidence at transcript level;
KW Abscisic acid signaling pathway; Metal-binding; Nucleus;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..260
FT /note="Zinc finger protein 4"
FT /id="PRO_0000047845"
FT ZN_FING 85..107
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 119..143
FT /note="RMGLAGVFPGRGSSSNYAAAATAAA -> LWVLLGSSPVEDQVAIMRLLPQQ
FT P (in Ref. 1; AAA87300)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 260 AA; 28309 MW; 48484EC120250F09 CRC64;
MRPILDLEIE ASSGSSSSQV ASNLSPVGED YKPISLNLSL SFNNNNNNNL DLESSSLTLP
LSSTSESSNP EQQQQQQPSV SKRVFSCNYC QRKFYSSQAL GGHQNAHKRE RTLAKRAMRM
GLAGVFPGRG SSSNYAAAAT AAALSCLPLH GSGNGNMTSF RTLGIRAHSS AHDVSMTRQT
PETLIRNIAR FNQGYFGNCI PFYVEDDEAE MLWPGSFRQA TNAVAVEAGN DNLGERKMDF
LDVKQAMDME SSLPDLTLKL
