ZFP57_RAT
ID ZFP57_RAT Reviewed; 406 AA.
AC A0JPK3; Q6MFY0;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Zinc finger protein 57;
DE Short=Zfp-57;
GN Name=Zfp57;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15060004; DOI=10.1101/gr.1987704;
RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H.,
RA Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT "The genomic sequence and comparative analysis of the rat major
RT histocompatibility complex.";
RL Genome Res. 14:631-639(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=15070898; DOI=10.1074/jbc.m400415200;
RA Alonso M.B., Zoidl G., Taveggia C., Bosse F., Zoidl C., Rahman M.,
RA Parmantier E., Dean C.H., Harris B.S., Wrabetz L., Mueller H.W.,
RA Jessen K.R., Mirsky R.;
RT "Identification and characterization of ZFP-57, a novel zinc finger
RT transcription factor in the mammalian peripheral nervous system.";
RL J. Biol. Chem. 279:25653-25664(2004).
CC -!- FUNCTION: Transcription regulator required to maintain maternal and
CC paternal gene imprinting, a process by which gene expression is
CC restricted in a parent of origin-specific manner by epigenetic
CC modification of genomic DNA and chromatin, including DNA methylation.
CC Acts by controlling DNA methylation during the earliest multicellular
CC stages of development at multiple imprinting control regions (ICRs).
CC Acts together with ZNF445. Required for the establishment of maternal
CC methylation imprints at SNRPN locus. Acts as a transcriptional
CC repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence
CC and recognizes the methylated CpG within this element.
CC {ECO:0000250|UniProtKB:Q8C6P8}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8C6P8}.
CC Note=Binds various differentially methylated regions (DMR), including
CC the Snrpn DMR. {ECO:0000250|UniProtKB:Q8C6P8}.
CC -!- TISSUE SPECIFICITY: Expressed in oligodendrocytes and at lower levels
CC in astrocytes. {ECO:0000269|PubMed:15070898}.
CC -!- DOMAIN: The KRAB domain is required for function as transcriptional
CC repressor. {ECO:0000250}.
CC -!- DOMAIN: Zinc fingers 2 and 3 mediate recognition of the target element,
CC ZF2 interacting with the 5' half (TGC) and ZF3 interacting with the 3'
CC half (CGC). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; BX883052; CAE84067.1; -; Genomic_DNA.
DR EMBL; BC127468; AAI27469.1; -; mRNA.
DR RefSeq; NP_998730.2; NM_213565.4.
DR RefSeq; XP_008770916.1; XM_008772694.2.
DR AlphaFoldDB; A0JPK3; -.
DR SMR; A0JPK3; -.
DR STRING; 10116.ENSRNOP00000011704; -.
DR PaxDb; A0JPK3; -.
DR PRIDE; A0JPK3; -.
DR Ensembl; ENSRNOT00000011704; ENSRNOP00000011704; ENSRNOG00000022730.
DR GeneID; 361783; -.
DR KEGG; rno:361783; -.
DR UCSC; RGD:1302981; rat.
DR CTD; 346171; -.
DR RGD; 1302981; Zfp57.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00390000002599; -.
DR HOGENOM; CLU_677857_0_0_1; -.
DR InParanoid; A0JPK3; -.
DR OMA; CGKLFWS; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; A0JPK3; -.
DR TreeFam; TF337947; -.
DR Reactome; R-RNO-212436; Generic Transcription Pathway.
DR PRO; PR:A0JPK3; -.
DR Proteomes; UP000002494; Chromosome 20.
DR Bgee; ENSRNOG00000022730; Expressed in cerebellum and 18 other tissues.
DR Genevisible; A0JPK3; RN.
DR GO; GO:0000792; C:heterochromatin; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0003682; F:chromatin binding; ISO:RGD.
DR GO; GO:0003677; F:DNA binding; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0010385; F:double-stranded methylated DNA binding; ISO:RGD.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043045; P:DNA methylation involved in embryo development; ISS:UniProtKB.
DR GO; GO:0071514; P:genomic imprinting; ISO:RGD.
DR GO; GO:0010216; P:maintenance of DNA methylation; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0006349; P:regulation of gene expression by genomic imprinting; ISS:UniProtKB.
DR GO; GO:2000653; P:regulation of genetic imprinting; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..406
FT /note="Zinc finger protein 57"
FT /id="PRO_0000291966"
FT DOMAIN 17..88
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 90..113
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 140..162
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 168..190
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 270..292
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 318..337
FT /note="C2H2-type 5; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 57..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 178
FT /note="Crucial for 5-methylcytosine recognition"
FT /evidence="ECO:0000250"
FT CONFLICT 8..9
FT /note="Missing (in Ref. 1; CAE84067)"
FT /evidence="ECO:0000305"
FT CONFLICT 202..206
FT /note="Missing (in Ref. 1; CAE84067)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 406 AA; 46588 MW; 24EB880DD59244C0 CRC64;
MAAKKQSKSA KALRTTVRYE DVAVSFTQEE WEYLTSTQKT LYQKVMSETF KNLTFVESKK
KPQEPNPNLK DKDDDKSSTC TGVFKGGPFF FCLTCGKCFK KNTFLFNHQF PVRSRRLAVT
KPQSRKALGH KPQHRGDRPF FCNLCGKTYR DASGLSRHRR AHVGYRPRSC PECGKCFRDQ
SEVNRHLKVH QNKKPVAGSH VKVHQNKPVA SNQKQKGRVP PTTRESPAPA LRHLKVIQGP
VARAKARSSR ASSLEVRSTS VTVARPREKV YCPYCRITFT MRTCLLNHLK IHFRRQPNQH
FCCKESHSSN TLRMQKIYNC PVCDSSFRGK ESLLNHLCSR RPIRLSKCWE ILGHLLGYLR
EPLGNIFKVR ESRKRRRKRI SSDSSETEGP SGSDEVMEVD TDSDLS
