ZFP58_MOUSE
ID ZFP58_MOUSE Reviewed; 489 AA.
AC P16372; Q3TS54; Q6P8L3; Q7M6X1; Q8BRV1;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 2.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Zinc finger protein 58;
DE Short=Zfp-58;
DE AltName: Full=Regulator of sex-limitation candidate 5;
DE AltName: Full=Zinc finger protein Mfg-1;
GN Name=Zfp58; Synonyms=Mfg-1, Rslcan5, Zfp817;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=14563677; DOI=10.1101/gad.1135703;
RA Krebs C.J., Larkins L.K., Price R., Tullis K.M., Miller R.D., Robins D.M.;
RT "Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes
RT that control sexually dimorphic liver gene expression.";
RL Genes Dev. 17:2664-2674(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Aorta, Egg, Placenta, and Vein;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 99-239, FUNCTION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=2512579; DOI=10.1073/pnas.86.23.9417;
RA Passananti C., Felsani A., Caruso M., Amati P.;
RT "Mouse genes coding for 'zinc-finger'-containing proteins: characterization
RT and expression in differentiated cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:9417-9421(1989).
CC -!- FUNCTION: May have a role during differentiation processes.
CC {ECO:0000269|PubMed:2512579}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in liver, testis and, at considerably
CC lower levels, in brain, spleen and heart. {ECO:0000269|PubMed:2512579}.
CC -!- DEVELOPMENTAL STAGE: Expression increases upon differentiation and is
CC not related to the cell cycle. {ECO:0000269|PubMed:2512579}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH61200.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; BK001635; DAA01860.1; -; mRNA.
DR EMBL; AK041250; BAC30880.1; -; mRNA.
DR EMBL; AK162259; BAE36821.1; -; mRNA.
DR EMBL; AK167399; BAE39488.1; -; mRNA.
DR EMBL; CH466661; EDL10303.1; -; Genomic_DNA.
DR EMBL; CH466661; EDL10304.1; -; Genomic_DNA.
DR EMBL; BC061200; AAH61200.1; ALT_SEQ; mRNA.
DR EMBL; BC139150; AAI39151.1; -; mRNA.
DR EMBL; BC139151; AAI39152.1; -; mRNA.
DR EMBL; M28513; AAA39531.1; -; mRNA.
DR CCDS; CCDS26616.1; -.
DR PIR; A39240; A39240.
DR RefSeq; NP_001007576.1; NM_001007575.2.
DR AlphaFoldDB; P16372; -.
DR SMR; P16372; -.
DR BioGRID; 232010; 32.
DR STRING; 10090.ENSMUSP00000075487; -.
DR iPTMnet; P16372; -.
DR PhosphoSitePlus; P16372; -.
DR PaxDb; P16372; -.
DR PRIDE; P16372; -.
DR ProteomicsDB; 299548; -.
DR DNASU; 238693; -.
DR Ensembl; ENSMUST00000076123; ENSMUSP00000075487; ENSMUSG00000071291.
DR Ensembl; ENSMUST00000171518; ENSMUSP00000132285; ENSMUSG00000071291.
DR GeneID; 238693; -.
DR KEGG; mmu:238693; -.
DR UCSC; uc007rax.2; mouse.
DR CTD; 238693; -.
DR MGI; MGI:99205; Zfp58.
DR VEuPathDB; HostDB:ENSMUSG00000071291; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000153165; -.
DR HOGENOM; CLU_476683_0_0_1; -.
DR InParanoid; P16372; -.
DR OMA; RRHLMIH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P16372; -.
DR TreeFam; TF338849; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 238693; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Zfp58; mouse.
DR PRO; PR:P16372; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; P16372; protein.
DR Bgee; ENSMUSG00000071291; Expressed in animal zygote and 62 other tissues.
DR ExpressionAtlas; P16372; baseline and differential.
DR Genevisible; P16372; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..489
FT /note="Zinc finger protein 58"
FT /id="PRO_0000047302"
FT DOMAIN 2..73
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 78..100
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 106..128
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 134..156
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 162..184
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 190..212
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 218..240
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 246..268
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 274..296
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 302..324
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 330..352
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 358..380
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 386..408
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 410..432
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 438..460
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 466..488
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 190
FT /note="Y -> YKCEECGKAFSTSSNLSEHKRIHTGEKPI (in Ref. 5;
FT AAA39531)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 489 AA; 57232 MW; 32A9FFF460AEE061 CRC64;
MLSFWDVAID FSPEERECLE PDQWDLYRDV MLENYSHLDF LGLALSKPFL VTFLEQRQGP
WDVKRQAAAA VHPGKTVNKC KDFSKAFFCK SLLTQHQRIR TGEKAFKCEE CGKAFNNRSN
LSEHKRIHTG EKPYKCEECG KAFRIRSKLS THQRVHTGEK PYKCEECGKA FNSHSNLSEH
KRIHTGEKPY KCEECGKAFS TRSTYYRHQK NHTGKKPYKC EECAKEFSYP SLLKVHQRIH
SAEKSYKCEE CGKPFYCPLL LKKHQIIHSA EKPYKCAECG KAFHYPSLLK RHQRIHAGKK
PCKCKDCDRA FYSSAFLKRH QRIHSEENSY KCGECGKRFC SFPHLQYHQR FHSGEKPYKC
EQCGKTFSTL SYLPWHKLRH SGEKSYKCEK CGKMFYSTLD LKKHQKIHEY KCGECHYGFP
NYAALTAHQR VHTGEKPHVC EQCGKDFSRI DSLNQHQLVH TGEKPYKCEK CGKCFYRSSS
LKRHQGIHS
