ZFP59_MOUSE
ID ZFP59_MOUSE Reviewed; 634 AA.
AC P16373; Q61849;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Zinc finger protein 59;
DE Short=Zfp-59;
DE AltName: Full=Zinc finger protein Mfg-2;
GN Name=Zfp59; Synonyms=Mfg2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC STRAIN=BALB/cJ; TISSUE=Testis;
RX PubMed=8547218;
RA Passananti C., Corbi N., Paggi M.G., Russo M.A., Perez M., Cotelli F.,
RA Stefanini M., Amati P.;
RT "The product of Zfp59 (Mfg2), a mouse gene expressed at the spermatid stage
RT of spermatogenesis, accumulates in spermatozoa nuclei.";
RL Cell Growth Differ. 6:1037-1044(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 158-563.
RC STRAIN=CD-1; TISSUE=Skeletal muscle;
RX PubMed=2512579; DOI=10.1073/pnas.86.23.9417;
RA Passananti C., Felsani A., Caruso M., Amati P.;
RT "Mouse genes coding for 'zinc-finger'-containing proteins: characterization
RT and expression in differentiated cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:9417-9421(1989).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=25609838; DOI=10.1095/biolreprod.114.126250;
RA Petit F.G., Kervarrec C., Jamin S.P., Smagulova F., Hao C., Becker E.,
RA Jegou B., Chalmel F., Primig M.;
RT "Combining RNA and protein profiling data with network interactions
RT identifies genes associated with spermatogenesis in mouse and human.";
RL Biol. Reprod. 92:71-71(2015).
CC -!- FUNCTION: May have a role during differentiation processes.
CC {ECO:0000269|PubMed:8547218}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8547218}.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in the testis (at protein
CC level). {ECO:0000269|PubMed:25609838}.
CC -!- DEVELOPMENTAL STAGE: Expression is positively regulated upon
CC differentiation. Is specifically synthesized during postmeiotic phase
CC of male germline differentiation.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; L16904; AAA92741.1; -; mRNA.
DR EMBL; M28514; AAA39532.1; -; mRNA.
DR PIR; B39240; B39240.
DR AlphaFoldDB; P16373; -.
DR SMR; P16373; -.
DR STRING; 10090.ENSMUSP00000103968; -.
DR iPTMnet; P16373; -.
DR PhosphoSitePlus; P16373; -.
DR PaxDb; P16373; -.
DR PRIDE; P16373; -.
DR ProteomicsDB; 274984; -.
DR MGI; MGI:99206; Zfp59.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; P16373; -.
DR PhylomeDB; P16373; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR PRO; PR:P16373; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P16373; protein.
DR GO; GO:0001673; C:male germ cell nucleus; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00355; ZnF_C2H2; 16.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 15.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 16.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..634
FT /note="Zinc finger protein 59"
FT /id="PRO_0000047303"
FT DOMAIN 1..44
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 130..152
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 158..180
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 214..236
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 242..264
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 270..292
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 298..320
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 326..348
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 354..376
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 382..404
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 410..432
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 438..459
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 465..487
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 493..515
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 521..543
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 549..571
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 577..599
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 163
FT /note="C -> S (in Ref. 2; AAA39532)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 634 AA; 72538 MW; A89A76641D1384F5 CRC64;
MLETYSNLVA VVGSCISKPN LIVLLEQEKE PWMAVNEETG RPSPDLEADY DAENISPQNR
IYNRKFSKQS IKQLSRTFDP KGSWFSNGPN YSTFHGLRDC QSDAGQQITN KEGVPPHTCQ
TLAHNTEKPY ECKECGKCFG CRSTLTQHQS VHTGEKPYEC KECGKAFRLP QQLTRHQKCH
SGEKPFSHNE GRQAFQHPNL LKYPKAIHTG AKAFACRECG KSFNRVSSLV EHGLIHADVK
PYECNECGKA FKRHRSFVRH QKIHSGERPF QCKDCGKGFI VLAHLTRHQS SHSEEKPFEC
EECGKKFRTA RHLVKHQRIH SGEKPFECNV CGSAFRLQLY LSEHQKTHME EKYLECNVCG
KAFRLQDILS EHLKTHTEEN PFKCKLCGSS FPHKYQLNKH LTVHTDGKPY QCKECGKCFR
QRSKLTEHES IHTGKKPFQC EACGKSLANT LLIHHQKSHS GERPFECKEC GKAFLLPSQL
NSHKIVHTSK RPFECKVCGK SFKRESNLIQ HGAVHAGVKS YECSECGKGF IDRSSLFHHR
KIHSDEKPFK CQECGKAFVV LAYLIEHQSI HTGEKPFECE LCGSAFRCRS QLNKHLRIHT
VRNITTVKNV GRPLVEYETC FDILNIIVIR SLMM
