ZFP5_ARATH
ID ZFP5_ARATH Reviewed; 211 AA.
AC Q39264; Q29PR6; Q8LCZ7;
DT 27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 145.
DE RecName: Full=Zinc finger protein 5 {ECO:0000305};
GN Name=ZFP5 {ECO:0000303|PubMed:7599312}; OrderedLocusNames=At1g10480;
GN ORFNames=T10O24.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Landsberg erecta; TISSUE=Root;
RX PubMed=7599312; DOI=10.1007/bf00020246;
RA Tague B.W., Goodman H.M.;
RT "Characterization of a family of Arabidopsis zinc finger protein cDNAs.";
RL Plant Mol. Biol. 28:267-279(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=21803862; DOI=10.1104/pp.111.180281;
RA Zhou Z., An L., Sun L., Zhu S., Xi W., Broun P., Yu H., Gan Y.;
RT "Zinc finger protein5 is required for the control of trichome initiation by
RT acting upstream of zinc finger protein8 in Arabidopsis.";
RL Plant Physiol. 157:673-682(2011).
RN [8]
RP FUNCTION, TISSUE SPECIFICITY, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22762888; DOI=10.1111/j.1365-313x.2012.05094.x;
RA An L., Zhou Z., Sun L., Yan A., Xi W., Yu N., Cai W., Chen X., Yu H.,
RA Schiefelbein J., Gan Y.;
RT "A zinc finger protein gene ZFP5 integrates phytohormone signaling to
RT control root hair development in Arabidopsis.";
RL Plant J. 72:474-490(2012).
RN [9]
RP FUNCTION.
RX PubMed=22301962; DOI=10.4161/psb.7.1.18404;
RA Zhou Z., An L., Sun L., Gan Y.;
RT "ZFP5 encodes a functionally equivalent GIS protein to control trichome
RT initiation.";
RL Plant Signal. Behav. 7:28-30(2012).
CC -!- FUNCTION: Probable transcription factor required for the initiation of
CC inflorescence trichomes in response to gibberellin (GA). Acts upstream
CC of GIS, GIS2, ZFP8 and the trichome initiation regulators GL1 and GL3
CC (PubMed:21803862, PubMed:22301962). Binds the promoter region of ZFP8,
CC which may be a direct target of ZPF5 (PubMed:21803862). Is not involved
CC in the regulation of trichome branching (PubMed:22301962). Modulates
CC root hair initiation and elongation in response to cytokinin and
CC ethylene signals by directly promoting expression of the CAPRICE (CPC)
CC gene (PubMed:22762888). {ECO:0000269|PubMed:21803862,
CC ECO:0000269|PubMed:22301962, ECO:0000269|PubMed:22762888}.
CC -!- INTERACTION:
CC Q39264; Q8LPR5: TCP4; NbExp=3; IntAct=EBI-15197231, EBI-15192325;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q39261}.
CC -!- TISSUE SPECIFICITY: Highly expressed in roots, young leaves, developing
CC stems, branches, inflorescence meristems, floral meristems and
CC siliques. Expressed at low levels in rosette and cauline leaves.
CC {ECO:0000269|PubMed:21803862, ECO:0000269|PubMed:22762888}.
CC -!- INDUCTION: By cytokinin and ethylene. {ECO:0000269|PubMed:22762888}.
CC -!- DISRUPTION PHENOTYPE: Reduced trichome production on sepals, cauline
CC leaves, paraclades and main inflorescence stems. Reduced number and
CC size of root hairs, due to reduced growth rate.
CC {ECO:0000269|PubMed:21803862, ECO:0000269|PubMed:22762888}.
CC -!- MISCELLANEOUS: Plants over-expressing ZFP5 show formation of ectopic
CC trichomes on carpels and other inflorescence organs.
CC {ECO:0000305|PubMed:21803862}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM64374.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; L39648; AAA87301.1; -; mRNA.
DR EMBL; AC007067; AAD39569.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28584.1; -; Genomic_DNA.
DR EMBL; BT024840; ABD60723.1; -; mRNA.
DR EMBL; AB493446; BAH30284.1; -; mRNA.
DR EMBL; AY086302; AAM64374.1; ALT_INIT; mRNA.
DR PIR; S55885; S55885.
DR RefSeq; NP_172518.1; NM_100922.3.
DR AlphaFoldDB; Q39264; -.
DR BioGRID; 22828; 19.
DR IntAct; Q39264; 18.
DR STRING; 3702.AT1G10480.1; -.
DR PaxDb; Q39264; -.
DR PRIDE; Q39264; -.
DR ProteomicsDB; 232304; -.
DR EnsemblPlants; AT1G10480.1; AT1G10480.1; AT1G10480.
DR GeneID; 837588; -.
DR Gramene; AT1G10480.1; AT1G10480.1; AT1G10480.
DR KEGG; ath:AT1G10480; -.
DR Araport; AT1G10480; -.
DR TAIR; locus:2194599; AT1G10480.
DR HOGENOM; CLU_091153_0_0_1; -.
DR InParanoid; Q39264; -.
DR OMA; NEQSGEM; -.
DR OrthoDB; 1355966at2759; -.
DR PhylomeDB; Q39264; -.
DR PRO; PR:Q39264; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q39264; baseline and differential.
DR Genevisible; Q39264; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IMP:TAIR.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0009740; P:gibberellic acid mediated signaling pathway; IMP:TAIR.
DR GO; GO:0048510; P:regulation of timing of transition from vegetative to reproductive phase; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0048767; P:root hair elongation; IMP:UniProtKB.
DR GO; GO:0048766; P:root hair initiation; IMP:UniProtKB.
DR GO; GO:0010026; P:trichome differentiation; IMP:TAIR.
DR GO; GO:0010090; P:trichome morphogenesis; IEA:InterPro.
DR InterPro; IPR044299; GIS3/ZFP5/ZFP6.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR46353; PTHR46353; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW Cytokinin signaling pathway; Developmental protein; Differentiation;
KW Ethylene signaling pathway; Gibberellin signaling pathway; Metal-binding;
KW Nucleus; Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..211
FT /note="Zinc finger protein 5"
FT /id="PRO_0000047846"
FT ZN_FING 60..82
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 211 AA; 23590 MW; C7F7C6C6C5F5E2B5 CRC64;
MSINPTMSRT GESSSGSSSD KTIKLFGFEL ISGSRTPEIT TAESVSSSTN TTSLTVMKRH
ECQYCGKEFA NSQALGGHQN AHKKERLKKK RLQLQARRAS IGYYLTNHQQ PITTSFQRQY
KTPSYCAFSS MHVNNDQMGV YNEDWSSRSS QINFGNNDTC QDLNEQSGEM GKLYGVRPNM
IQFQRDLSSR SDQMRSINSL DLHLGFAGDA A
