ZFP69_BOVIN
ID ZFP69_BOVIN Reviewed; 524 AA.
AC A7MBI1;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Zinc finger protein 69 homolog {ECO:0000250|UniProtKB:A2A761};
DE AltName: Full=Zinc finger protein 642;
GN Name=ZFP69; Synonyms=ZNF642;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal muscle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative transcription factor that appears to regulate lipid
CC metabolism. {ECO:0000250|UniProtKB:A2A761}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A2A761}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC151573; AAI51574.1; -; mRNA.
DR RefSeq; NP_001095533.1; NM_001102063.1.
DR AlphaFoldDB; A7MBI1; -.
DR SMR; A7MBI1; -.
DR STRING; 9913.ENSBTAP00000048845; -.
DR PaxDb; A7MBI1; -.
DR PRIDE; A7MBI1; -.
DR Ensembl; ENSBTAT00000052349; ENSBTAP00000048845; ENSBTAG00000039287.
DR GeneID; 521549; -.
DR KEGG; bta:521549; -.
DR CTD; 339559; -.
DR VEuPathDB; HostDB:ENSBTAG00000039287; -.
DR VGNC; VGNC:37168; ZFP69.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162278; -.
DR HOGENOM; CLU_002678_0_9_1; -.
DR InParanoid; A7MBI1; -.
DR OMA; QTILTHK; -.
DR OrthoDB; 1318335at2759; -.
DR TreeFam; TF337055; -.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000039287; Expressed in oocyte and 104 other tissues.
DR ExpressionAtlas; A7MBI1; baseline and differential.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0019216; P:regulation of lipid metabolic process; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 2: Evidence at transcript level;
KW DNA-binding; Lipid metabolism; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..524
FT /note="Zinc finger protein 69 homolog"
FT /id="PRO_0000355566"
FT DOMAIN 1..39
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT DOMAIN 74..146
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 269..291
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 297..319
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 325..347
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 353..375
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 381..403
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 409..431
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 437..459
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 465..487
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 493..515
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 49..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 524 AA; 60808 MW; 1607942ABF596FBA CRC64;
MLQQLLITLP TEASTWVKLH HPENAKEGAP LWEDVTKMFE GGALLSQDAD ETQGESLKDE
LTPGTPTTDS QELLTFKDIS VDFTQEEWGQ LAPAHRNLYR EVMLENYGNL VSVAGCQLSK
PSVISQLEKG EEPWMTEKEG PGDPNSDLKS KTETSASNAK YNILQEQLYH GMMMERFMRD
DVIYSTLKKV SEYDDELEKH QDRHGRNVRQ TIMTHKKRSQ ETYKFGKNIV SSNVVIEQRL
RKCDTPRKRN KCKSDVINHP TSYIRVKTYE CNICEKAFKQ PIHLTEHMRI HTGEKPFRCK
ECGRAFSQSA SLTTHQRIHT GEKPFECEEC GKAFRHRSSL NQHHRTHTGE KPYICDKCQK
AFSQNISLIQ HLRTHSGEKP FTCNECGKTF RQIRHLSEHI RIHTGEKPYA CTACCKTFSH
RAYLTHHQRI HTGERPYKCK ECGKAFRQRI HLSNHKTVHT GVKAYECNRC GKAYRHDSSF
KKHQRHHTGE KPYECNECGK AFSYNSSLTR HHEIHRRNVF QNNI
