ZFP6_ARATH
ID ZFP6_ARATH Reviewed; 197 AA.
AC Q39265;
DT 27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Zinc finger protein 6 {ECO:0000305};
GN Name=ZFP6 {ECO:0000303|PubMed:7599312}; Synonyms=ZEP6;
GN OrderedLocusNames=At1g67030; ORFNames=F1O19.8, F1O19_5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Landsberg erecta; TISSUE=Root;
RX PubMed=7599312; DOI=10.1007/bf00020246;
RA Tague B.W., Goodman H.M.;
RT "Characterization of a family of Arabidopsis zinc finger protein cDNAs.";
RL Plant Mol. Biol. 28:267-279(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=23506479; DOI=10.1111/nph.12211;
RA Zhou Z., Sun L., Zhao Y., An L., Yan A., Meng X., Gan Y.;
RT "Zinc finger protein 6 (ZFP6) regulates trichome initiation by integrating
RT gibberellin and cytokinin signaling in Arabidopsis thaliana.";
RL New Phytol. 198:699-708(2013).
RN [6]
RP FUNCTION.
RX PubMed=24808098; DOI=10.1104/pp.113.234294;
RA Joseph M.P., Papdi C., Kozma-Bognar L., Nagy I., Lopez-Carbonell M.,
RA Rigo G., Koncz C., Szabados L.;
RT "The Arabidopsis ZINC FINGER PROTEIN3 interferes with abscisic acid and
RT light signaling in seed germination and plant development.";
RL Plant Physiol. 165:1203-1220(2014).
CC -!- FUNCTION: Probable transcription factor required for the initiation of
CC inflorescence trichomes in response to gibberellin and cytokinin. Acts
CC upstream of GIS, GIS2, ZFP8, ZFP5 and the trichome initiation
CC regulators GL1 and GL3 (PubMed:23506479). Acts as negative regulator of
CC abscisic acid (ABA) signaling during germination and early seedling
CC development (PubMed:24808098). {ECO:0000269|PubMed:23506479,
CC ECO:0000269|PubMed:24808098}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q39261}.
CC -!- TISSUE SPECIFICITY: Highly expressed in roots, mature stem and lateral
CC branches. Expressed at low levels in rosette leaves and siliques.
CC {ECO:0000269|PubMed:23506479}.
CC -!- INDUCTION: By cytokinin and gibberellin. {ECO:0000269|PubMed:23506479}.
CC -!- DISRUPTION PHENOTYPE: Reduced number of trichomes on sepals, cauline
CC leaves, lateral branches and main inflorescence stems.
CC {ECO:0000269|PubMed:23506479}.
CC -!- MISCELLANEOUS: Seeds over-expressing ZFP6 are insensitive to inhibition
CC of germination by abscisic acid (ABA) (PubMed:24808098). Plants over-
CC expressing ZFP6 show formation of ectopic trichomes on carpels and
CC other inflorescence organs (Probable). {ECO:0000269|PubMed:24808098,
CC ECO:0000305|PubMed:23506479}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L39649; AAA87302.1; -; mRNA.
DR EMBL; AC007152; AAF98212.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34586.1; -; Genomic_DNA.
DR EMBL; AY050387; AAK91404.1; -; mRNA.
DR EMBL; AY093800; AAM10416.1; -; mRNA.
DR PIR; S55886; S55886.
DR RefSeq; NP_176873.1; NM_105372.3.
DR AlphaFoldDB; Q39265; -.
DR BioGRID; 28243; 5.
DR IntAct; Q39265; 5.
DR STRING; 3702.AT1G67030.1; -.
DR PaxDb; Q39265; -.
DR PRIDE; Q39265; -.
DR ProteomicsDB; 242938; -.
DR EnsemblPlants; AT1G67030.1; AT1G67030.1; AT1G67030.
DR GeneID; 843022; -.
DR Gramene; AT1G67030.1; AT1G67030.1; AT1G67030.
DR KEGG; ath:AT1G67030; -.
DR Araport; AT1G67030; -.
DR TAIR; locus:2019723; AT1G67030.
DR eggNOG; ENOG502QTV9; Eukaryota.
DR HOGENOM; CLU_091153_0_0_1; -.
DR InParanoid; Q39265; -.
DR OMA; FNISEDH; -.
DR OrthoDB; 1532684at2759; -.
DR PhylomeDB; Q39265; -.
DR PRO; PR:Q39265; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q39265; baseline and differential.
DR Genevisible; Q39265; AT.
DR GO; GO:0022626; C:cytosolic ribosome; HDA:TAIR.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IMP:TAIR.
DR GO; GO:0009740; P:gibberellic acid mediated signaling pathway; IMP:TAIR.
DR GO; GO:0009788; P:negative regulation of abscisic acid-activated signaling pathway; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0010026; P:trichome differentiation; IMP:TAIR.
DR GO; GO:0010090; P:trichome morphogenesis; IEA:InterPro.
DR InterPro; IPR044299; GIS3/ZFP5/ZFP6.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR46353; PTHR46353; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 2: Evidence at transcript level;
KW Abscisic acid signaling pathway; Cytokinin signaling pathway;
KW Developmental protein; Differentiation; Gibberellin signaling pathway;
KW Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..197
FT /note="Zinc finger protein 6"
FT /id="PRO_0000047847"
FT ZN_FING 41..63
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 197 AA; 21414 MW; C7A9BFCC05A698D8 CRC64;
MATETSSLKL FGINLLETTS VQNQSSEPRP GSGSGSESRK YECQYCCREF ANSQALGGHQ
NAHKKERQLL KRAQMLATRG LPRHHNFHPH TNPLLSAFAP LPHLLSQPHP PPHMMLSPSS
SSSKWLYGEH MSSQNAVGYF HGGRGLYGGG MESMAGEVKT HGGSLPEMRR FAGDSDRSSG
IKLENGIGLD LHLSLGP
