ZFP82_MOUSE
ID ZFP82_MOUSE Reviewed; 530 AA.
AC Q6P9Y7; Q6ZPG0; Q8BIP1;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Zinc finger protein 82;
DE Short=Zfp-82;
DE AltName: Full=Zinc finger protein 545;
GN Name=Zfp82; Synonyms=Kiaa1948, Znf545;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-530 (ISOFORM 2).
RC TISSUE=Embryonic tail;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6P9Y7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P9Y7-2; Sequence=VSP_018083;
CC Name=3;
CC IsoId=Q6P9Y7-3; Sequence=VSP_046230, VSP_046231;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC29755.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK037211; BAC29755.1; ALT_SEQ; mRNA.
DR EMBL; BC060530; AAH60530.1; -; mRNA.
DR EMBL; AK129467; BAC98277.1; -; mRNA.
DR CCDS; CCDS39876.1; -. [Q6P9Y7-1]
DR CCDS; CCDS59724.1; -. [Q6P9Y7-3]
DR RefSeq; NP_001239448.1; NM_001252519.1.
DR RefSeq; NP_001240314.1; NM_001253385.1. [Q6P9Y7-3]
DR RefSeq; NP_808557.2; NM_177889.5. [Q6P9Y7-1]
DR AlphaFoldDB; Q6P9Y7; -.
DR SMR; Q6P9Y7; -.
DR BioGRID; 236978; 2.
DR IntAct; Q6P9Y7; 2.
DR STRING; 10090.ENSMUSP00000079647; -.
DR PhosphoSitePlus; Q6P9Y7; -.
DR MaxQB; Q6P9Y7; -.
DR PaxDb; Q6P9Y7; -.
DR PRIDE; Q6P9Y7; -.
DR ProteomicsDB; 274988; -. [Q6P9Y7-1]
DR ProteomicsDB; 274989; -. [Q6P9Y7-2]
DR Antibodypedia; 16307; 131 antibodies from 20 providers.
DR DNASU; 330502; -.
DR Ensembl; ENSMUST00000080834; ENSMUSP00000079647; ENSMUSG00000098022. [Q6P9Y7-1]
DR Ensembl; ENSMUST00000183190; ENSMUSP00000138469; ENSMUSG00000098022. [Q6P9Y7-3]
DR GeneID; 330502; -.
DR KEGG; mmu:330502; -.
DR UCSC; uc009gcz.2; mouse. [Q6P9Y7-1]
DR UCSC; uc009gdc.2; mouse. [Q6P9Y7-3]
DR CTD; 284406; -.
DR MGI; MGI:1890753; Zfp82.
DR VEuPathDB; HostDB:ENSMUSG00000098022; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162531; -.
DR HOGENOM; CLU_002678_69_8_1; -.
DR InParanoid; Q6P9Y7; -.
DR OMA; QHQSIHV; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6P9Y7; -.
DR TreeFam; TF341817; -.
DR BioGRID-ORCS; 330502; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Zfp82; mouse.
DR PRO; PR:Q6P9Y7; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q6P9Y7; protein.
DR Bgee; ENSMUSG00000098022; Expressed in cortical plate and 66 other tissues.
DR ExpressionAtlas; Q6P9Y7; baseline and differential.
DR Genevisible; Q6P9Y7; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..530
FT /note="Zinc finger protein 82"
FT /id="PRO_0000233165"
FT DOMAIN 6..77
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 168..190
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 196..218
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 224..246
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 252..274
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 280..302
FT /note="C2H2-type 5; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 308..330
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 336..358
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 364..386
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 392..414
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 420..442
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 448..470
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 476..498
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 504..526
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 125
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N141"
FT VAR_SEQ 68..76
FT /note="VRQRKPCPD -> TMGDPGRTN (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14621295"
FT /id="VSP_018083"
FT VAR_SEQ 76..83
FT /note="DSETKDET -> ARRDGASL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_046230"
FT VAR_SEQ 84..530
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_046231"
SQ SEQUENCE 530 AA; 62122 MW; 87CFAFB2A3CF1BD6 CRC64;
MARVSVVFSD VSIAFSQEEW ESLDLEQRNL YKDVMMENYH NVASLGCFIS KPDVISLLEQ
GKEPWKVVRQ RKPCPDSETK DETNQVFSEN GIYEMNLSQW KIMERIGNSG LKSLLLKNGW
ESRRKQERQE DPQEGYLSQV RHTSERVSSY EKRALTTRQR IHFVEKPYEC NECGKAFRVR
QQLTFHHRIH TGEKPYECKE CGMAFRQTAH LTRHQRLHSG EKLYECKECG QAFIYGPELR
AHQKLHTGEK PYTCRECGKA FRVRGQLTLH QRIHTGEKPY VCQECGKAFR QLAHLTRHQK
LNVVDRLYEC KECGKDFLCG SGLRVHHKLH TGEKPYECKD CGKAFRVRQQ LTLHQRSHTG
EKPYECTECG KTFSRGYHLI LHHRIHTGEK PYECKECWKA FSRYSQLISH QSIHIGVKPY
DCKDCGKAFR LLSQLTQHQS VHAGEKPYSC KECGKSFRLR QKLALHQSIH TGEKPFECKE
CRKAFRLNSS LIQHLRIHSG EKPYECKECK KAFRQHSHLT HHLKVHTVKV
