ZFP90_RAT
ID ZFP90_RAT Reviewed; 633 AA.
AC Q4V8A8;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Zinc finger protein 90;
DE Short=Zfp-90;
GN Name=Zfp90;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Inhibits the transcriptional repressor activity of REST by
CC inhibiting its binding to DNA, thereby derepressing transcription of
CC REST target genes. {ECO:0000250|UniProtKB:Q61967}.
CC -!- SUBUNIT: Interacts (via N- and C-termini) with REST (via zinc-finger
CC DNA-binding domain); the interaction inhibits REST repressor activity.
CC {ECO:0000250|UniProtKB:Q61967}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61967}.
CC Note=Colocalizes with REST in the nucleus.
CC {ECO:0000250|UniProtKB:Q61967}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; BC097467; AAH97467.1; -; mRNA.
DR RefSeq; NP_001020936.1; NM_001025765.1.
DR RefSeq; XP_017456837.1; XM_017601348.1.
DR AlphaFoldDB; Q4V8A8; -.
DR SMR; Q4V8A8; -.
DR STRING; 10116.ENSRNOP00000027209; -.
DR iPTMnet; Q4V8A8; -.
DR PhosphoSitePlus; Q4V8A8; -.
DR PaxDb; Q4V8A8; -.
DR GeneID; 498945; -.
DR KEGG; rno:498945; -.
DR UCSC; RGD:1563077; rat.
DR CTD; 146198; -.
DR RGD; 1563077; Zfp90.
DR VEuPathDB; HostDB:ENSRNOG00000020087; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q4V8A8; -.
DR OMA; TLEDTWD; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q4V8A8; -.
DR TreeFam; TF350822; -.
DR Reactome; R-RNO-212436; Generic Transcription Pathway.
DR PRO; PR:Q4V8A8; -.
DR Proteomes; UP000002494; Chromosome 19.
DR Bgee; ENSRNOG00000020087; Expressed in cerebellum and 19 other tissues.
DR ExpressionAtlas; Q4V8A8; baseline and differential.
DR Genevisible; Q4V8A8; RN.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0003677; F:DNA binding; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043392; P:negative regulation of DNA binding; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Repressor; Transcription; Transcription regulation;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..633
FT /note="Zinc finger protein 90"
FT /id="PRO_0000233977"
FT DOMAIN 14..85
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 209..231
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 251..273
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 279..301
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 307..329
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 335..357
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 363..385
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 391..413
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 447..469
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 494..516
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 522..544
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 550..572
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 578..600
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 606..628
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 445
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8TF47"
SQ SEQUENCE 633 AA; 72438 MW; 4FAFD3846C712653 CRC64;
MAPRPPTATP QESVTFKDVA VNFTQEEWRH VGPAQRSLYR DVMLENYSHL VSLGYQVSKP
EVIFKLEQGE EPWISERELQ RPFCPDWKTR PDIKSWSSQQ GVSEVSHSAN VWSHATFGDI
WGVNTQRHQE SWRRHLGPEA SSQKKITALE KIAEQNKFGE DSGLSTDLVP QLDVSSSIRP
SECKTFGNNL EYNSELVTQS GIPAKKKPYK CDKCRKSFIH RSSLNKHEKI HKDDAYSNGT
DQGVPSGRKH HECTDCGKTF LWRTQLTEHQ RIHTGEKPFE CNVCGKAFRH SSSLGQHENA
HTGEKPYQCS LCGKAFQRSS SLVQHQRIHT GEKPYRCNLC GRSFRHSTSL TQHEVTHSGE
KPFQCKECGK AFSRCSSLVQ HERTHTGEKP FECSICGRAF GQSPSLYKHM RIHKRSKPYQ
SNNFSIAFEP NIPLTQGESV LTDVKSYHCI DCGKDFSHIT DFTEHQRIHA GENSYDSEQA
LRQQSLSHPR EKPYQCNVCG KAFKRSTSFI EHHRIHTGEK PYECNECGEA FSRLSSLTQH
ERTHTGEKPY ECIDCGKAFS QSSSLIQHER THTGEKPYEC NECGRAFRKK TNLHDHQRIH
TGEKPYACKE CGKNFSRSSA LTKHHRIHSR NKL
