CC178_MOUSE
ID CC178_MOUSE Reviewed; 866 AA.
AC Q8CDV0; B7ZN78;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Coiled-coil domain-containing protein 178;
GN Name=Ccdc178;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK029534; BAC26501.1; -; mRNA.
DR EMBL; BC140993; AAI40994.1; -; mRNA.
DR EMBL; BC145066; AAI45067.1; -; mRNA.
DR CCDS; CCDS29092.1; -.
DR RefSeq; NP_081892.2; NM_027616.3.
DR AlphaFoldDB; Q8CDV0; -.
DR SMR; Q8CDV0; -.
DR STRING; 10090.ENSMUSP00000025160; -.
DR iPTMnet; Q8CDV0; -.
DR PhosphoSitePlus; Q8CDV0; -.
DR PaxDb; Q8CDV0; -.
DR PRIDE; Q8CDV0; -.
DR ProteomicsDB; 265296; -.
DR Antibodypedia; 48809; 19 antibodies from 12 providers.
DR Ensembl; ENSMUST00000025160; ENSMUSP00000025160; ENSMUSG00000024306.
DR Ensembl; ENSMUST00000115837; ENSMUSP00000111503; ENSMUSG00000024306.
DR Ensembl; ENSMUST00000234736; ENSMUSP00000157323; ENSMUSG00000024306.
DR GeneID; 70950; -.
DR KEGG; mmu:70950; -.
DR UCSC; uc008efk.1; mouse.
DR CTD; 374864; -.
DR MGI; MGI:1918200; Ccdc178.
DR VEuPathDB; HostDB:ENSMUSG00000024306; -.
DR eggNOG; ENOG502R7DC; Eukaryota.
DR GeneTree; ENSGT00390000012215; -.
DR HOGENOM; CLU_012461_0_0_1; -.
DR InParanoid; Q8CDV0; -.
DR OMA; RKENMEY; -.
DR OrthoDB; 710456at2759; -.
DR PhylomeDB; Q8CDV0; -.
DR TreeFam; TF337479; -.
DR BioGRID-ORCS; 70950; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Ccdc178; mouse.
DR PRO; PR:Q8CDV0; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q8CDV0; protein.
DR Bgee; ENSMUSG00000024306; Expressed in spermatid and 7 other tissues.
DR ExpressionAtlas; Q8CDV0; baseline and differential.
DR GO; GO:0036064; C:ciliary basal body; ISO:MGI.
DR InterPro; IPR038826; CCDC178.
DR PANTHER; PTHR35088; PTHR35088; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..866
FT /note="Coiled-coil domain-containing protein 178"
FT /id="PRO_0000223317"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 157..266
FT /evidence="ECO:0000255"
FT COILED 292..403
FT /evidence="ECO:0000255"
FT COILED 439..480
FT /evidence="ECO:0000255"
FT COILED 514..539
FT /evidence="ECO:0000255"
FT COILED 570..631
FT /evidence="ECO:0000255"
FT COILED 665..705
FT /evidence="ECO:0000255"
FT CONFLICT 350
FT /note="D -> H (in Ref. 1; BAC26501)"
FT /evidence="ECO:0000305"
FT CONFLICT 742
FT /note="K -> N (in Ref. 1; BAC26501)"
FT /evidence="ECO:0000305"
FT CONFLICT 831
FT /note="N -> D (in Ref. 1; BAC26501)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 866 AA; 103041 MW; 954D746D61D71BAC CRC64;
MPENEKEPAQ PTTNEDALDT GKTCLQIKEL KDKERALMLA ENARMQGLSE FFFSRHEDKR
LYESKSTNTE DVNKAIYFSY PSRRHSCTLV NIPKPCVNKM ISHIEDVESK IQEHLTQFEA
SFEEWTSVTK DKEAGLDVSA PEKQVHPEKG KDEKCPELKK RMETLLSEAI HLIKSLETDR
AEAEQALKQH KSRKKKISMK IDSWSIWKLQ ELPLAVQKEH ENFSKINAEL RSYLEDIALK
VEQLQERKEK LEKANAKLQV DIDYMASHSV LLEKKRKQEL GCLKERYHKK FEVMEKFRAI
HEELKESVDK CEGAKARLKN MKVENEREIQ EELINATSYE KELDKLSVLD AHYTTSIETV
NLDIEGDEEA MNEVLRETQS TTNELENLKK TVDDLKRLFD QYCWRQRKYE NEYLEAFSNF
YSLKKTWDIE LSNVSKDAKD LTIVYEAQSE ENKRIQSEIQ SITDDIEESI KKTAEMEEEV
HTFVEMKMKN NNYLKQLYKQ AYQVGAVYHL SRHKTEELED KLADLKRIFK GREELLKKLT
RGDIATGIEI QKRLYAIEET QFIEMQEFIR RQVLYNMALL EVEEQLKELE AEAVRIRYLH
RQHSKMLHNI RKRKERVKKN VDATKKKLLK KSKKSRMELT RTEGKRSIIH EEIEIARGQT
VALHEKCIEL SKEIRIMNLE RTNYEERLKK LQEEFFKLQF DREHVHGVYD HLMREKQYCE
ERIFEEERRF RRLIDMRKNT LKNIRKCQDD LLEENLRLAK EYQSAQLIFL KEKESYFNGY
DRLLSLNFSL SDKKKLCQLQ KRLDQKWQEY FRLMILFNKT KLAKFQGDSQ NSIQKILAVQ
EESSSLMQHI LDFFKSFPNS SCGEDD
