ZFP92_HUMAN
ID ZFP92_HUMAN Reviewed; 416 AA.
AC A6NM28;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 3.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Zinc finger protein 92 homolog;
DE Short=Zfp-92;
GN Name=ZFP92;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-290.
RA Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.;
RT "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in
RT human.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; U82695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DR731275; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS59177.1; -.
DR RefSeq; NP_001129745.1; NM_001136273.1.
DR RefSeq; XP_005274709.1; XM_005274652.3.
DR RefSeq; XP_011529417.1; XM_011531115.2.
DR AlphaFoldDB; A6NM28; -.
DR SMR; A6NM28; -.
DR STRING; 9606.ENSP00000462054; -.
DR iPTMnet; A6NM28; -.
DR PhosphoSitePlus; A6NM28; -.
DR BioMuta; ZFP92; -.
DR MassIVE; A6NM28; -.
DR MaxQB; A6NM28; -.
DR PaxDb; A6NM28; -.
DR PeptideAtlas; A6NM28; -.
DR PRIDE; A6NM28; -.
DR ProteomicsDB; 1507; -.
DR Antibodypedia; 63851; 39 antibodies from 13 providers.
DR DNASU; 139735; -.
DR Ensembl; ENST00000338647.7; ENSP00000462054.1; ENSG00000189420.9.
DR GeneID; 139735; -.
DR KEGG; hsa:139735; -.
DR MANE-Select; ENST00000338647.7; ENSP00000462054.1; NM_001136273.2; NP_001129745.1.
DR UCSC; uc011myo.3; human.
DR CTD; 139735; -.
DR GeneCards; ZFP92; -.
DR HGNC; HGNC:12865; ZFP92.
DR HPA; ENSG00000189420; Low tissue specificity.
DR neXtProt; NX_A6NM28; -.
DR OpenTargets; ENSG00000189420; -.
DR PharmGKB; PA37454; -.
DR VEuPathDB; HostDB:ENSG00000189420; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162887; -.
DR HOGENOM; CLU_002678_93_0_1; -.
DR InParanoid; A6NM28; -.
DR OMA; ILYKQVM; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; A6NM28; -.
DR TreeFam; TF337732; -.
DR PathwayCommons; A6NM28; -.
DR SignaLink; A6NM28; -.
DR BioGRID-ORCS; 139735; 12 hits in 718 CRISPR screens.
DR GenomeRNAi; 139735; -.
DR Pharos; A6NM28; Tdark.
DR PRO; PR:A6NM28; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; A6NM28; protein.
DR Bgee; ENSG00000189420; Expressed in Brodmann (1909) area 23 and 147 other tissues.
DR Genevisible; A6NM28; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..416
FT /note="Zinc finger protein 92 homolog"
FT /id="PRO_0000328807"
FT DOMAIN 14..85
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 152..174
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 180..202
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 208..230
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 236..258
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 264..286
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 292..314
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 320..342
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 348..370
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 86..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 273..276
FT /note="FSRS -> LSQR (in Ref. 2; DR731275)"
FT /evidence="ECO:0000305"
FT CONFLICT 281
FT /note="E -> D (in Ref. 2; DR731275)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 416 AA; 45791 MW; BC5C71E88267EC4C CRC64;
MAAILLTTRP KVPVSFEDVS VYFTKTEWKL LDLRQKVLYK RVMLENYSHL VSLGFSFSKP
HLISQLERGE GPWVADIPRT WATAGLHIGD RTQSKTSTST QKHSGRQLPG ADPQGGKEGQ
AARSSVLQRG AQGLGQSSAA GPQGPKGAEK RYLCQQCGKA FSRSSNLIKH RIIHSGEKPY
ACPECGKLFR RSFALLEHQR IHSGEKPYAC PECSKTFTRS SNLIKHQVIH SGERPFACGD
CGKLFRRSFA LLEHARVHSG ERPYACPECG KAFSRSSNLI EHQRTHRGEK PYACGQCAKA
FKGVSQLIHH QRSHSGERPF ACRECGKAFR GRSGLSQHRR VHSGEKPYEC SDCGKAFGRR
ANLFKHQAVH GARRPAKAET ARRLAGPGST GPGSAVAATS PPRPSTAARP SRPSRR
