ID   ZFPL1_CAEEL             Reviewed;         309 AA.
AC   Q9N4Y9; Q966C0;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Zinc finger protein-like 1 homolog;
GN   ORFNames=Y45G12B.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=Q9N4Y9-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=Q9N4Y9-2; Sequence=VSP_035880;
CC   -!- SIMILARITY: Belongs to the ZFPL1 family. {ECO:0000305}.
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DR   EMBL; FO080651; CCD65494.1; -; Genomic_DNA.
DR   EMBL; FO080651; CCD65496.1; -; Genomic_DNA.
DR   RefSeq; NP_503731.1; NM_071330.3. [Q9N4Y9-1]
DR   RefSeq; NP_503732.2; NM_071331.4.
DR   AlphaFoldDB; Q9N4Y9; -.
DR   BioGRID; 43791; 1.
DR   DIP; DIP-24811N; -.
DR   IntAct; Q9N4Y9; 1.
DR   STRING; 6239.Y45G12B.2a; -.
DR   EPD; Q9N4Y9; -.
DR   PaxDb; Q9N4Y9; -.
DR   PeptideAtlas; Q9N4Y9; -.
DR   EnsemblMetazoa; Y45G12B.2a.1; Y45G12B.2a.1; WBGene00021563. [Q9N4Y9-1]
DR   EnsemblMetazoa; Y45G12B.2b.1; Y45G12B.2b.1; WBGene00021563.
DR   GeneID; 178734; -.
DR   KEGG; cel:CELE_Y45G12B.2; -.
DR   UCSC; Y45G12B.2a; c. elegans.
DR   CTD; 178734; -.
DR   WormBase; Y45G12B.2a; CE21934; WBGene00021563; -. [Q9N4Y9-1]
DR   WormBase; Y45G12B.2b; CE51119; WBGene00021563; -.
DR   eggNOG; KOG3970; Eukaryota.
DR   GeneTree; ENSGT00390000009753; -.
DR   HOGENOM; CLU_075387_0_0_1; -.
DR   InParanoid; Q9N4Y9; -.
DR   OMA; PNCALCN; -.
DR   OrthoDB; 807302at2759; -.
DR   PhylomeDB; Q9N4Y9; -.
DR   PRO; PR:Q9N4Y9; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00021563; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   ExpressionAtlas; Q9N4Y9; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR039043; ZFPL1.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12981; PTHR12981; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Membrane; Metal-binding; Reference proteome;
KW   Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..309
FT                   /note="Zinc finger protein-like 1 homolog"
FT                   /id="PRO_0000355176"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         1..43
FT                   /note="B box-type; degenerate"
FT   ZN_FING         53..101
FT                   /note="RING-type; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          200..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..72
FT                   /note="MGLCKCPKRKVTNLFCYEHRVNVCEFCLVDNHPNCVVQSYLTWLTDQDYDPN
FT                   CSLCKTTLAEGDTIRLNCLH -> MNTPEGRGD (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_035880"
SQ   SEQUENCE   309 AA;  34815 MW;  CF6D5930D1D0192D CRC64;
     MGLCKCPKRK VTNLFCYEHR VNVCEFCLVD NHPNCVVQSY LTWLTDQDYD PNCSLCKTTL
     AEGDTIRLNC LHLLHWKCFD EWAANFPATT APAGYRCPCC SQEVFPPINE VSPLIEKLRE
     QLKQSNWARA ALGLPTLPEL NRPVPSPAPP QLKNAPVMHK EVPVHNNRSS TPATHLEMED
     TASYSVSNND VTFARKKNYG AESSSDTRPL LQLRDADNEE NKYKRRPTMD WMRGLWRAKH
     GGSGVPQERA SAKKIALFVI FLAVLALITI IMVMKRAGYS GEHSSDPLFD PMANPNIRVA
     VEDSRLPHV