ZFR2_HUMAN
ID ZFR2_HUMAN Reviewed; 939 AA.
AC Q9UPR6; B4DHD0;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Zinc finger RNA-binding protein 2;
GN Name=ZFR2; Synonyms=KIAA1086;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-188 (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-939 (ISOFORM 1), AND VARIANT
RP MET-183.
RC TISSUE=Brain;
RX PubMed=10470851; DOI=10.1093/dnares/6.3.197;
RA Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A.,
RA Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIV. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:197-205(1999).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9UPR6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UPR6-2; Sequence=VSP_040635, VSP_040636;
CC Name=3;
CC IsoId=Q9UPR6-3; Sequence=VSP_057301, VSP_057302;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK295037; BAG58091.1; -; mRNA.
DR EMBL; DA237746; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC004598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC005777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC034005; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AB029009; BAA83038.1; -; mRNA.
DR CCDS; CCDS45921.1; -. [Q9UPR6-1]
DR CCDS; CCDS45922.1; -. [Q9UPR6-2]
DR RefSeq; NP_001139112.1; NM_001145640.1. [Q9UPR6-2]
DR RefSeq; NP_055989.1; NM_015174.1. [Q9UPR6-1]
DR AlphaFoldDB; Q9UPR6; -.
DR SMR; Q9UPR6; -.
DR BioGRID; 116824; 3.
DR IntAct; Q9UPR6; 1.
DR STRING; 9606.ENSP00000262961; -.
DR iPTMnet; Q9UPR6; -.
DR PhosphoSitePlus; Q9UPR6; -.
DR BioMuta; ZFR2; -.
DR DMDM; 296453074; -.
DR MassIVE; Q9UPR6; -.
DR PaxDb; Q9UPR6; -.
DR PeptideAtlas; Q9UPR6; -.
DR PRIDE; Q9UPR6; -.
DR ProteomicsDB; 4210; -.
DR ProteomicsDB; 85428; -. [Q9UPR6-1]
DR Antibodypedia; 52596; 8 antibodies from 7 providers.
DR DNASU; 23217; -.
DR Ensembl; ENST00000262961.9; ENSP00000262961.3; ENSG00000105278.12. [Q9UPR6-1]
DR Ensembl; ENST00000438164.2; ENSP00000388974.2; ENSG00000105278.12. [Q9UPR6-3]
DR Ensembl; ENST00000439086.2; ENSP00000388567.1; ENSG00000105278.12. [Q9UPR6-2]
DR GeneID; 23217; -.
DR KEGG; hsa:23217; -.
DR MANE-Select; ENST00000262961.9; ENSP00000262961.3; NM_015174.2; NP_055989.1.
DR UCSC; uc002lyw.3; human. [Q9UPR6-1]
DR CTD; 23217; -.
DR DisGeNET; 23217; -.
DR GeneCards; ZFR2; -.
DR HGNC; HGNC:29189; ZFR2.
DR HPA; ENSG00000105278; Group enriched (brain, pituitary gland, retina, testis).
DR MIM; 619284; gene.
DR neXtProt; NX_Q9UPR6; -.
DR OpenTargets; ENSG00000105278; -.
DR PharmGKB; PA162409746; -.
DR VEuPathDB; HostDB:ENSG00000105278; -.
DR eggNOG; KOG3792; Eukaryota.
DR GeneTree; ENSGT00940000162148; -.
DR HOGENOM; CLU_012026_1_0_1; -.
DR InParanoid; Q9UPR6; -.
DR OMA; MTATDSC; -.
DR OrthoDB; 612611at2759; -.
DR PhylomeDB; Q9UPR6; -.
DR TreeFam; TF320194; -.
DR PathwayCommons; Q9UPR6; -.
DR BioGRID-ORCS; 23217; 10 hits in 1074 CRISPR screens.
DR ChiTaRS; ZFR2; human.
DR GenomeRNAi; 23217; -.
DR Pharos; Q9UPR6; Tdark.
DR PRO; PR:Q9UPR6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9UPR6; protein.
DR Bgee; ENSG00000105278; Expressed in pituitary gland and 125 other tissues.
DR ExpressionAtlas; Q9UPR6; baseline and differential.
DR Genevisible; Q9UPR6; HS.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.460.10; -; 1.
DR InterPro; IPR006561; DZF_dom.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF07528; DZF; 1.
DR SMART; SM00572; DZF; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SMART; SM00451; ZnF_U1; 3.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS51703; DZF; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..939
FT /note="Zinc finger RNA-binding protein 2"
FT /id="PRO_0000308958"
FT DOMAIN 570..935
FT /note="DZF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01040"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 906..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 516..549
FT /evidence="ECO:0000255"
FT COMPBIAS 217..242
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 913..939
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 19..70
FT /note="AQPPTLPLPTVGASYTAQPTPGMDPAVNPAFPPAAPAGYGGYQPHSGQDFAY
FT -> PEVETTPPALASGLPCALPWTVGCSGSDAVTALCPSLRGLACICSILWDPAW (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040635"
FT VAR_SEQ 71..939
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040636"
FT VAR_SEQ 346..366
FT /note="VFKLHAKLGKPIPTLEPALAT -> GLLSHRQQAADPSGGNQPNLN (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_057301"
FT VAR_SEQ 367..939
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_057302"
FT VARIANT 164
FT /note="S -> L (in dbSNP:rs2240235)"
FT /id="VAR_036886"
FT VARIANT 183
FT /note="V -> M (in dbSNP:rs2240234)"
FT /evidence="ECO:0000269|PubMed:10470851"
FT /id="VAR_036887"
FT VARIANT 210
FT /note="V -> L (in dbSNP:rs2240233)"
FT /id="VAR_036888"
FT VARIANT 235
FT /note="P -> L (in dbSNP:rs2240232)"
FT /id="VAR_036889"
FT VARIANT 577
FT /note="A -> T (in dbSNP:rs2301843)"
FT /id="VAR_036890"
FT VARIANT 589
FT /note="D -> N (in dbSNP:rs2301839)"
FT /id="VAR_036891"
FT VARIANT 718
FT /note="I -> M (in dbSNP:rs45465594)"
FT /id="VAR_061730"
FT CONFLICT 181
FT /note="S -> F (in Ref. 4; DA237746)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 939 AA; 101330 MW; 94E63C2C1C13C845 CRC64;
MATSQYFDFA QGGGPQYSAQ PPTLPLPTVG ASYTAQPTPG MDPAVNPAFP PAAPAGYGGY
QPHSGQDFAY GSRPQEPVPT ATTMATYQDS YSYGQSAAAR SYEDRPYFQS AALQSGRMTA
ADSGQPGTQE ACGQPSPHGS HSHAQPPQQA PIVESGQPAS TLSSGYTYPT ATGVQPESSA
SIVTSYPPPS YNPTCTAYTA PSYPNYDASV YSAASPFYPP AQPPPPPGPP QQLPPPPAPA
GSGSSPRADS KPPLPSKLPR PKAGPRQLQL HYCDICKISC AGPQTYREHL GGQKHRKKEA
AQKTGVQPNG SPRGVQAQLH CDLCAVSCTG ADAYAAHIRG SKHQKVFKLH AKLGKPIPTL
EPALATESPP GAEAKPTSPT GPSVCASSRP ALAKRPVASK ALCEGPPEPQ AAGCRPQWGK
PAQPKLEGPG APTQGGSKEA PAGCSDAQPV GPEYVEEVFS DEGRVLRFHC KLCECSFNDL
NAKDLHVRGR RHRLQYRKKV NPDLPIATEP SSRARKVLEE RMRKQRHLAE ERLEQLRRWH
AERRRLEEEP PQDVPPHAPP DWAQPLLMGR PESPASAPLQ PGRRPASSDD RHVMCKHATI
YPTEQELLAV QRAVSHAERA LKLVSDTLAE EDRGRREEEG DKRSSVAPQT RVLKGVMRVG
ILAKGLLLRG DRNVRLALLC SEKPTHSLLR RIAQQLPRQL QMVTEDEYEV SSDPEANIVI
SSCEEPRMQV TISVTSPLMR EDPSTDPGVE EPQADAGDVL SPKKCLESLA ALRHARWFQA
RASGLQPCVI VIRVLRDLCR RVPTWGALPA WAMELLVEKA VSSAAGPLGP GDAVRRVLEC
VATGTLLTDG PGLQDPCERD QTDALEPMTL QEREDVTASA QHALRMLAFR QTHKVLGMDL
LPPRHRLGAR FRKRQRGPGE GEEGAGEKKR GRRGGEGLV
