ID   ZFR_DANRE               Reviewed;        1074 AA.
AC   Q6PCR6;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Zinc finger RNA-binding protein;
GN   Name=zfr;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in postimplantation and gastrulation stages of
CC       development. Binds to DNA and RNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH59198.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC059198; AAH59198.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q6PCR6; -.
DR   SMR; Q6PCR6; -.
DR   STRING; 7955.ENSDARP00000069275; -.
DR   PaxDb; Q6PCR6; -.
DR   ZFIN; ZDB-GENE-030131-378; zfr.
DR   eggNOG; KOG3792; Eukaryota.
DR   InParanoid; Q6PCR6; -.
DR   PhylomeDB; Q6PCR6; -.
DR   PRO; PR:Q6PCR6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR   GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.460.10; -; 1.
DR   InterPro; IPR006561; DZF_dom.
DR   InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF07528; DZF; 1.
DR   SMART; SM00572; DZF; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SMART; SM00451; ZnF_U1; 3.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS51703; DZF; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Repeat; RNA-binding.
FT   CHAIN           1..1074
FT                   /note="Zinc finger RNA-binding protein"
FT                   /id="PRO_0000312723"
FT   DOMAIN          697..1073
FT                   /note="DZF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01040"
FT   REGION          344..374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          412..456
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          508..545
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          697..718
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          761..781
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1036..1074
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        356..374
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..456
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        697..712
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        764..781
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1048..1074
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1074 AA;  116523 MW;  3401EB8F7AF55E3C CRC64;
     MIPICPVVSF TYVPSRLGED AKMATGNYFG FTHGAGAQYS QQPAAGVAYT HPTTVASYTV
     HQAPVAAHTV AAAYAPTAAT VAVARPAPVA VAAAANAAAF GGYQPAHAAT DYGYAQRQPE
     VPPPPPPVTS QNYQDSYSYV RSTAPAVAYD SKQYYQQPAA TPAVAAAAAQ PQPTVAESYY
     QTAPKTGYSQ GATPYTQTQQ TRQVTVVKPA TPSPATSTFS IYPVSSAVQP VAAAAAASVV
     PSYSQSPTYS TNAVTYSGTS YSGYEAAVYS AASSYYQQQQ QQQKQAAVAA AATAAWTGST
     FTKKTPFQNK TLKPKQPPKP PQIHYCDVCK ISCAGPQTYK EHLEGQKHKK KEAALKVSQS
     SSSSSGGGSS ARGTQNQLRC ELCDVSCTGA DAYAAHIRGA KHQKVVKLHT KLGKPIPSTE
     PSVVSQSSTS STAAPNKTSS SNINSSTSTS SNASSSVSAS YLKSGSMAAS AAQGKSSGAN
     NVSVNSSSIK KVNTPKINFV GGNKLQTTAS KSDESKADAA KTAQSAASAP AADAKNDMPD
     PMSPQSALAA LQSDVQPVGH DYVEEVRNDE GKVIRFHCKL CECSFNDPNA KEMHLKGRRH
     RLQYKKKVNP DLQVEVKPSI RARKIQEEKM RKQMQKEEYW RRREEEERWR MEMRRYEEDM
     YWRRMEEEQH HWEDRRRMPD GGYPQGPPGP PGLLGVRPGM PIPQPQGPVP PRRPDSSDDR
     YVMTKHAAIY PSEDELQAIQ KIVSITERAL KLVSDIITDQ DAGASAKGKE EDKEKKEPPK
     DRLLKGVMRV GVLAKGLLLR GDKEVNLVLL CSEKPTKNLL TRIVEHLPKQ LTMVTPEKYE
     VKGSIQESAI ILTSCGDPKM QVTITLTSPI IREESSRDGD VTSSMVKDPA DVLDRQKCLD
     ALAALRHAKW FQARANGLQS CVIVIRILRD LCQRVPTWSA FPSWAMELLV EKAISSASGP
     MSPGDALRRV FECISSGILL SGAPGLIDPC EKNPTDTLAF MEEQQREDIT SSAQFALRLL
     AFRQIHKVLG MDPLPQMNSR FNVRNTRKRR RDNSDGADGF EAEGKKDKKD YEGF