ID   ZFR_XENLA               Reviewed;        1054 AA.
AC   Q6GPM1; Q8AVI6;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Zinc finger RNA-binding protein;
GN   Name=zfr;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in postimplantation and gastrulation stages of
CC       development. Binds to DNA and RNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH42260.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAH42260.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR   EMBL; BC042260; AAH42260.1; ALT_SEQ; mRNA.
DR   EMBL; BC073093; AAH73093.1; -; mRNA.
DR   RefSeq; NP_001083976.1; NM_001090507.1.
DR   AlphaFoldDB; Q6GPM1; -.
DR   SMR; Q6GPM1; -.
DR   DNASU; 399224; -.
DR   GeneID; 399224; -.
DR   KEGG; xla:399224; -.
DR   CTD; 399224; -.
DR   Xenbase; XB-GENE-6067516; zfr.S.
DR   OMA; QCSQQPA; -.
DR   OrthoDB; 612611at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 399224; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.460.10; -; 1.
DR   InterPro; IPR006561; DZF_dom.
DR   InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF07528; DZF; 1.
DR   SMART; SM00572; DZF; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SMART; SM00451; ZnF_U1; 3.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS51703; DZF; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Repeat; RNA-binding.
FT   CHAIN           1..1054
FT                   /note="Zinc finger RNA-binding protein"
FT                   /id="PRO_0000312724"
FT   DOMAIN          683..1053
FT                   /note="DZF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01040"
FT   REGION          342..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          491..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          657..702
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          741..761
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1023..1054
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        669..695
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1028..1054
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        460
FT                   /note="M -> L (in Ref. 1; AAH42260)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1054 AA;  115218 MW;  BF6071AF55F5FA4B CRC64;
     MIPICPVVSF TYVPSRLGEE AKMATGNYFG FTHGAAAQYS QQPASGVAYS HPTTVASYTV
     HQAPVAPHTV TAAYAPAVAT VAVARPAPVA MAATAAAYGG YPAAHTATDY GYTQRQQEAP
     PPPPPVTTQN YQDSYSYVRS TAPAVAYDSK QYYQQPTATA AAVAAQPQPS IAETYYQTVA
     PKAGYSQGAA QYTQAQQTRQ VTAIKPANPS PASTTFSIYP VSSSVQPVAA AASVVPSYTQ
     SATYSNTAVT YSGAAYSGYE AAVYSAASSY YQQQQQQQQK QAAAAAAAAA TAAWTGTNFT
     KKAPFQNKQL KPKQPPKPPQ IHYCDVCKIS CAGPQTYKEH LEGQKHKKKE AALKASQNTT
     SSSTAVRGTQ NQLRCELCDV SCTGADAYAA HIRGAKHQKV VKLHTKLGKP IPSTEPNVVS
     QSVTSAVSKA SATSSSTSSA NGSSSVASPA VKLLTSSSSM STSNSSKVSS ISSTSIVKKV
     TTPKITFIGG NKLQSTGNKV DDSKMSDISK ATPSSAAQTQ EVKIDPMSEA AQTLAALQSD
     VQPVGHDYVE EVRNDEGKVI RFHCKLCECS FNDPNAKEMH LKGRRHRLQY KKKVNPDLQV
     EVKPSIRARK IQEEKMRKQM QKEEYWRRRE EEDQWRMEMR RYEEDMYWRR MEEEQHHWDD
     RRRVPEGGYP HGPPGPPGLL GVRPGMPPQP QGPAPLRRPD SSDDRYVMTK HAAIYPTEDE
     LQAVQKIVSL TERALKLVSD SMTDQDKTKT KESDEKKEPT KERALKGVLR VGVLAKGLLL
     RGDRNVNLVL LCSEKPTRAL LSCISESLPT QLAVICPEKF EVTSSIPEAA IILNSCVEPK
     MQVTITLTSP VIREETPRDG DVTPGMVKDP PDVLDRQKCL DALASLRHAK WFQARANGLQ
     SCVIVIRILR DLCQRVPTWS DFPNWALELL VEKAISSSSG PQSPGDALRR VFECISSGII
     LKGGPGLLDP CEKDPYDTLA TMNDQQREDI TSSAQFALRL LAFRQIYKVL GMDPLSQTNQ
     RFNVHSNRKR RRDSDSVDSF EAEGKKDKKD YENF