ID   ZFR_XENTR               Reviewed;        1065 AA.
AC   Q5U231;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Zinc finger RNA-binding protein;
GN   Name=zfr;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in postimplantation and gastrulation stages of
CC       development. Binds to DNA and RNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}.
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DR   EMBL; BC086301; AAH86301.1; -; mRNA.
DR   RefSeq; NP_001011177.1; NM_001011177.1.
DR   RefSeq; XP_012816351.1; XM_012960897.2.
DR   AlphaFoldDB; Q5U231; -.
DR   SMR; Q5U231; -.
DR   STRING; 8364.ENSXETP00000034043; -.
DR   PRIDE; Q5U231; -.
DR   DNASU; 496597; -.
DR   Ensembl; ENSXETT00000034043; ENSXETP00000034043; ENSXETG00000015598.
DR   GeneID; 496597; -.
DR   KEGG; xtr:496597; -.
DR   CTD; 51663; -.
DR   Xenbase; XB-GENE-6067390; zfr.
DR   eggNOG; KOG3792; Eukaryota.
DR   InParanoid; Q5U231; -.
DR   OrthoDB; 612611at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000015598; Expressed in neurula embryo and 16 other tissues.
DR   ExpressionAtlas; Q5U231; differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR   GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.460.10; -; 1.
DR   InterPro; IPR006561; DZF_dom.
DR   InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF07528; DZF; 1.
DR   SMART; SM00572; DZF; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SMART; SM00451; ZnF_U1; 3.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS51703; DZF; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Repeat; RNA-binding.
FT   CHAIN           1..1065
FT                   /note="Zinc finger RNA-binding protein"
FT                   /id="PRO_0000312725"
FT   DOMAIN          694..1064
FT                   /note="DZF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01040"
FT   REGION          114..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          416..461
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          467..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          499..533
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          667..714
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          752..773
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1032..1065
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        423..461
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        680..706
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1039..1065
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1065 AA;  116167 MW;  D64EB3060B621AC9 CRC64;
     MIPICPVVSF TYVPSRLGEE AKMATGNYFG FTHGAAAQYS QQPASGVAYS HPTTVASYTV
     HQAPVAAHTV TAAYAPAAAT VAVARPAPVA VAAAATAAAY GGYPAAHTAT DYGYTQRQQE
     APPPPPPVTT QNYQDSYSYV RSTAPAVAYD SKQYYQQPTA TVAAAAQPQP AVAETYYQTA
     PIALSLPVAP KAGYSQGAAQ YTQAQQTRQV TAIKPANPSP ATTTFSIYPV SSTVQPVAAA
     ATVVPSYTQS ATYSTTAVTY SGAAYSGYEA AVYSAASSYY QQQQQQQQKQ AAAAAAAAAT
     AAWTGTNFTK KPQFQNKQLK PKQPPKPPQI HYCDVCKISC AGPQTYKEHL EGQKHKKKEA
     ALKASQNTTS SSTAVRGTQN QLRCELCDVS CTGADAYAAH IRGAKHQKVV KLHTKLGKPI
     PSTEPNVVSQ SVTSAAVSKP STTSSSTSGA NGSSSVGASP SVKLLTSSSS LSTSSSSKAS
     SMSSTSIVKK VTTPKITFIG GNKLQSTGNK VDDSKMSDSA KTTPSTAAQT QEAKIDPMSE
     AAQTLAALQS DVQPVGHDYV EEVRNDEGKV IRFHCKLCEC SFNDPNAKEM HLKGRRHRLQ
     YKKKVNPDLQ VEVKPSIRAR KIQEEKMRKQ MQKEEYWRRR EEEERWRMEM RRYEEDMYWR
     RMEEEQHHWD DRRRVPEGGY PHGPPGPPGL LGVRPGMPPQ PQGPSPLRRP DSSDDRYVMT
     KHAAIYPTEE ELQAVQKIVS LTERALKLVS DSMADQDKSK TKESDDKKEP SKERALKGVL
     RVGVLAKGLL LRGDRNVSLV LLCAEKPTRA LLSRITESLP KQLAVICPEK YEVSCSLAEA
     AIILNSCVEP KMQVTITLTS PVIREENLRD GDVTPGMVKD PPDVLDRQKC LDALAALRHA
     KWFQARANGL QSCVIIIRIL RDLCQRVPTW SDFPSWALEL LVEKAISSSS GPQSPGDALR
     RVFECISSGI ILKGGPGLLD PCEKDPYDTL ATMNDQQRED ITSSAQFALR LLAFRQIYKV
     LGMDPLSQMN QRFNVHNNRK RRRDSDGVDS FEAEGKKDKK DYDNF