ZFTA_MOUSE
ID ZFTA_MOUSE Reviewed; 678 AA.
AC Q4VA45;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Zinc finger translocation-associated protein {ECO:0000305};
DE Short=ZFTA {ECO:0000305};
GN Name=Zfta {ECO:0000312|MGI:MGI:1919667};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 203-678.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH96549.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
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DR EMBL; AC129188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC096549; AAH96549.1; ALT_SEQ; mRNA.
DR CCDS; CCDS29524.2; -.
DR RefSeq; NP_780590.3; NM_175381.6.
DR AlphaFoldDB; Q4VA45; -.
DR STRING; 10090.ENSMUSP00000123773; -.
DR iPTMnet; Q4VA45; -.
DR PhosphoSitePlus; Q4VA45; -.
DR MaxQB; Q4VA45; -.
DR PaxDb; Q4VA45; -.
DR PeptideAtlas; Q4VA45; -.
DR PRIDE; Q4VA45; -.
DR Antibodypedia; 72993; 49 antibodies from 13 providers.
DR DNASU; 108899; -.
DR Ensembl; ENSMUST00000159348; ENSMUSP00000123773; ENSMUSG00000053080.
DR GeneID; 108899; -.
DR KEGG; mmu:108899; -.
DR UCSC; uc008gkz.2; mouse.
DR CTD; 65998; -.
DR MGI; MGI:1919667; Zfta.
DR VEuPathDB; HostDB:ENSMUSG00000053080; -.
DR eggNOG; ENOG502QTI3; Eukaryota.
DR GeneTree; ENSGT00600000084617; -.
DR HOGENOM; CLU_035783_0_0_1; -.
DR InParanoid; Q4VA45; -.
DR OMA; WRMDYLM; -.
DR OrthoDB; 570589at2759; -.
DR PhylomeDB; Q4VA45; -.
DR TreeFam; TF337165; -.
DR BioGRID-ORCS; 108899; 3 hits in 70 CRISPR screens.
DR PRO; PR:Q4VA45; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q4VA45; protein.
DR Bgee; ENSMUSG00000053080; Expressed in humerus cartilage element and 216 other tissues.
DR ExpressionAtlas; Q4VA45; baseline and differential.
DR Genevisible; Q4VA45; MM.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR040647; SPIN-DOC_Znf-C2H2.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF18658; zf-C2H2_12; 4.
DR SMART; SM00355; ZnF_C2H2; 4.
PE 2: Evidence at transcript level;
KW Isopeptide bond; Reference proteome; Ubl conjugation.
FT CHAIN 1..678
FT /note="Zinc finger translocation-associated protein"
FT /id="PRO_0000393910"
FT REGION 1..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..201
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..243
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..576
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 375
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:C9JLR9"
SQ SEQUENCE 678 AA; 73710 MW; FC50843733D28C6B CRC64;
MEPGGDHRSR SGGGRGGPGP AVTSARGRRL PPTAASGGTE PEEDDGGQAL QLEGGALGSW
GSTPLPSSRA RGPASSGRKY SDHCEARASR PGKSRIPGRD HRRYYHDHWR LEYLMDFIPS
RHGMVCMVCG SSLATLKLST IKRHIRQKHP YSLHWSPREK EVISNSWDAH LGLGAGGEAE
SLGAQGAEEE EEEDEEEEEG ANLQACPPKG SGKAPAGGGC RRQRRGVRGG SVAPRRRRLA
ASRRAGGSRG LGARRLERRL KESLQNWFRA ECLMDYDPRG NRLVCMACGR ALPSLHLDDI
RAHVLEVHPS SLGLSGPQRS ALLQAWGDQP EALSELTQPS PDDDLVPQDL TRKSRDSAPA
AGAPSSQDLS PPDVKEEAGW VPERPGPAEE EEGEGEGERE GIPNRPRRGR DHRRHYQERW
RLEYLMELDG CRRGLVCMVC GGALASLKMS TIKRHIRQRH PGSNSLSGPV KALIAQEWSE
KAAHLLALGL PRPESPSVPV APSTASASEE GGGAEEAEPE EEWWGDAPLS PGAPSERPAE
EEDDEDDSQE PGGLAFPPLP LPPPPPPPPP PPRSREQRRN YQPRWRGEYL MDYDGSRRGL
VCMVCGGALA TLKVSTIKRH ILQVHPFSMD FTPEERQTIL EAYEEAALRC YGHEGFGPPA
PAPRDSGADL KPGAVCRA