ZFX_BOVIN
ID ZFX_BOVIN Reviewed; 800 AA.
AC O62836; Q95LI4;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Zinc finger X-chromosomal protein;
GN Name=ZFX;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Japanese black; TISSUE=Testis;
RX PubMed=9457673; DOI=10.1007/s003359900702;
RA Xiao C., Tsuchiya K., Sutou S.;
RT "Cloning and mapping of bovine ZFX gene to the long arm of the X-chromosome
RT (Xq34) and homologous mapping of ZFY gene to the distal region of the short
RT arm of the bovine (Yp13), ovine (Yp12-p13), and caprine (Yp12-p13) Y
RT chromosome.";
RL Mamm. Genome 9:125-130(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Poloumienko A., Blecher S.;
RT "Bovine ZFX and ZFY genes reveal extensive similarity to human zinc finger
RT protein genes.";
RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable transcriptional activator.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. ZFX/ZFY subfamily. {ECO:0000305}.
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DR EMBL; D84097; BAA28278.1; -; mRNA.
DR EMBL; AF032866; AAL18260.1; -; mRNA.
DR RefSeq; NP_803456.1; NM_177490.1.
DR AlphaFoldDB; O62836; -.
DR SMR; O62836; -.
DR STRING; 9913.ENSBTAP00000010165; -.
DR PaxDb; O62836; -.
DR PRIDE; O62836; -.
DR Ensembl; ENSBTAT00000010165; ENSBTAP00000010165; ENSBTAG00000007730.
DR Ensembl; ENSBTAT00000034353; ENSBTAP00000034250; ENSBTAG00000007730.
DR GeneID; 280961; -.
DR KEGG; bta:280961; -.
DR CTD; 7543; -.
DR VEuPathDB; HostDB:ENSBTAG00000007730; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000158684; -.
DR HOGENOM; CLU_021097_0_0_1; -.
DR InParanoid; O62836; -.
DR OMA; HREPKAQ; -.
DR OrthoDB; 1318335at2759; -.
DR TreeFam; TF335557; -.
DR Proteomes; UP000009136; Chromosome X.
DR Bgee; ENSBTAG00000007730; Expressed in spiral colon and 112 other tissues.
DR ExpressionAtlas; O62836; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009566; P:fertilization; IEA:Ensembl.
DR GO; GO:0048872; P:homeostasis of number of cells; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0048599; P:oocyte development; IEA:Ensembl.
DR GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
DR GO; GO:0060746; P:parental behavior; IEA:Ensembl.
DR GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR InterPro; IPR006794; Transcrp_activ_Zfx/Zfy-dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 7.
DR Pfam; PF04704; Zfx_Zfy_act; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..800
FT /note="Zinc finger X-chromosomal protein"
FT /id="PRO_0000047257"
FT ZN_FING 420..442
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 451..473
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 483..505
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 514..537
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 543..565
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 571..594
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 600..622
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 628..651
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 657..679
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 685..708
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 714..736
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 742..765
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 771..794
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT MOD_RES 269
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P17012"
FT CONFLICT 329..339
FT /note="AAAAAAAAAHE -> VPLQQPLPPMK (in Ref. 1; BAA28278)"
FT /evidence="ECO:0000305"
FT CONFLICT 363
FT /note="S -> Y (in Ref. 1; BAA28278)"
FT /evidence="ECO:0000305"
FT CONFLICT 376
FT /note="L -> F (in Ref. 1; BAA28278)"
FT /evidence="ECO:0000305"
FT CONFLICT 531
FT /note="R -> P (in Ref. 2; AAL18260)"
FT /evidence="ECO:0000305"
FT CONFLICT 557
FT /note="E -> K (in Ref. 2; AAL18260)"
FT /evidence="ECO:0000305"
FT CONFLICT 582
FT /note="D -> N (in Ref. 2; AAL18260)"
FT /evidence="ECO:0000305"
FT CONFLICT 619..620
FT /note="AL -> VF (in Ref. 2; AAL18260)"
FT /evidence="ECO:0000305"
FT CONFLICT 712
FT /note="L -> F (in Ref. 2; AAL18260)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 800 AA; 90175 MW; 6C785B739A0ABE0A CRC64;
MDEDGLELQP QEPNSFFDTT GADATHMDGD QIVVEVQETV FVSDVVDSDI TVHNFVPDDP
DSVVIQDVIE DVVIEDVQCP DIMEEADVSE TVIIPEQVLD SDVTEEVSLA HCTVPDDVLA
SDITSASMSM PEHVLTSESI HVSDIGHVEH VVHDSVVEAE IVTDPLTADV VSEEVLVADC
ASEAVIDANG IPVDQQEDDK GNCEDYLMIS LDDAGKIEHD GSSGMTMDAE SEIDPCKVDG
TCPEVIKVYI FKADPGEDDL GGTVDIVESE PENDHGVELL DQNNSIRVPR EKMVYMTVND
SQQEDEDLNV AEIADEVYME VIVGEEDAAA AAAAAAAHEQ QMDDNEIKTF MPIAWAAAYG
NNSDGIENRN GTASALLHID ESAGLGRLAK QKPKKRRRPD SRQYQTAIII GPDGHPLTVY
PCMICGKKFK SRGFLKRHMK NHPEHLTKKK YRCTDCDYTT NKKISLHNHL ESHKLTSKAE
KAIECDECGK HFSHAGALFT HKMVHKEKGA NKMHKCKFCE YETAEQGLLN RHLLAVHSKN
FPHICVECGK GFRHPSELKK HMRIHTGEKP YQCQYCEYRS ADSSNLKTHV KTKHSKEMPF
KCDICLLTFS DTKEVQQHAL IHQESKTHQC LHCDHKSSNS SDLKRHIISV HTKDYPHKCD
MCDKGFHRPS ELKKHVAAHK GKKMHQCRHC DFKIADPFVL SRHILSVHTK DLPFRCKRCR
KGFRQQNELK KHMKTHSGRK VYQCEYCEYS TTDASGFKRH VISIHTKDYP HRCEYCKKGF
RRPSEKNQHI MRHHKEVGLP
