ZFX_MOUSE
ID ZFX_MOUSE Reviewed; 799 AA.
AC P17012; P17011;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Zinc finger X-chromosomal protein;
GN Name=Zfx;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2105457; DOI=10.1128/mcb.10.2.681-688.1990;
RA Mardon G., Luoh S.-W., Simpson E.M., Gill G., Brown L.G., Page D.C.;
RT "Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating
RT domain and 13 zinc fingers.";
RL Mol. Cell. Biol. 10:681-688(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-216.
RC STRAIN=FVB/N; TISSUE=Testis;
RX PubMed=8188262; DOI=10.1006/geno.1994.1063;
RA Luoh S.-W., Page D.C.;
RT "The structure of the Zfx gene on the mouse X chromosome.";
RL Genomics 19:310-319(1994).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Lung, Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Probable transcriptional activator.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. ZFX/ZFY subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA40585.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown due to a duplication of 120 bp after position 480.; Evidence={ECO:0000305};
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DR EMBL; M32308; AAA40584.1; -; mRNA.
DR EMBL; M32309; AAA40585.1; ALT_SEQ; mRNA.
DR EMBL; L19714; AAA75393.1; -; mRNA.
DR CCDS; CCDS30276.1; -.
DR PIR; A34729; A34729.
DR RefSeq; NP_001037851.1; NM_001044386.1.
DR RefSeq; NP_035898.2; NM_011768.2.
DR RefSeq; XP_006528029.1; XM_006527966.3.
DR RefSeq; XP_011245879.1; XM_011247577.2.
DR RefSeq; XP_011245880.1; XM_011247578.2.
DR AlphaFoldDB; P17012; -.
DR SMR; P17012; -.
DR BioGRID; 204690; 1.
DR IntAct; P17012; 2.
DR MINT; P17012; -.
DR STRING; 10090.ENSMUSP00000085423; -.
DR iPTMnet; P17012; -.
DR PhosphoSitePlus; P17012; -.
DR EPD; P17012; -.
DR MaxQB; P17012; -.
DR PaxDb; P17012; -.
DR PRIDE; P17012; -.
DR ProteomicsDB; 299552; -.
DR Antibodypedia; 577; 180 antibodies from 28 providers.
DR DNASU; 22764; -.
DR Ensembl; ENSMUST00000088102; ENSMUSP00000085423; ENSMUSG00000079509.
DR Ensembl; ENSMUST00000113926; ENSMUSP00000109559; ENSMUSG00000079509.
DR Ensembl; ENSMUST00000113927; ENSMUSP00000109560; ENSMUSG00000079509.
DR GeneID; 22764; -.
DR KEGG; mmu:22764; -.
DR UCSC; uc009tsz.1; mouse.
DR CTD; 7543; -.
DR MGI; MGI:99211; Zfx.
DR VEuPathDB; HostDB:ENSMUSG00000079509; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000158684; -.
DR HOGENOM; CLU_021097_0_0_1; -.
DR InParanoid; P17012; -.
DR OMA; HREPKAQ; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P17012; -.
DR TreeFam; TF335557; -.
DR BioGRID-ORCS; 22764; 14 hits in 71 CRISPR screens.
DR ChiTaRS; Zfx; mouse.
DR PRO; PR:P17012; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; P17012; protein.
DR Bgee; ENSMUSG00000079509; Expressed in metanephric mesenchyme and 252 other tissues.
DR ExpressionAtlas; P17012; baseline and differential.
DR Genevisible; P17012; MM.
DR GO; GO:0000785; C:chromatin; ISO:MGI.
DR GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0043035; F:chromatin insulator sequence binding; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0009566; P:fertilization; IMP:MGI.
DR GO; GO:0007281; P:germ cell development; IMP:MGI.
DR GO; GO:0048872; P:homeostasis of number of cells; IMP:MGI.
DR GO; GO:0035264; P:multicellular organism growth; IMP:MGI.
DR GO; GO:0048599; P:oocyte development; IMP:MGI.
DR GO; GO:0001541; P:ovarian follicle development; IMP:MGI.
DR GO; GO:0060746; P:parental behavior; IMP:MGI.
DR GO; GO:0009791; P:post-embryonic development; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IMP:MGI.
DR InterPro; IPR006794; Transcrp_activ_Zfx/Zfy-dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 8.
DR Pfam; PF04704; Zfx_Zfy_act; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..799
FT /note="Zinc finger X-chromosomal protein"
FT /id="PRO_0000047259"
FT ZN_FING 419..444
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 450..472
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 482..504
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 513..536
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 542..564
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 570..593
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 599..621
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 627..650
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 656..678
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 684..707
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 713..735
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 741..764
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 770..792
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT MOD_RES 269
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
SQ SEQUENCE 799 AA; 90026 MW; 3FB6B4D2159EADFD CRC64;
MDEDGLELQQ QAPNSFFDAT GAGATHMDGN QIVVEVQETV YVSDVVDSDI TVHNYVPDDP
DSVVIQDVIE DVVIEDVQCT DIMDEADVSE TVIIPEQVLD SDVTEEVSLT HCTVPDDVLA
SDITSASISM PEHVLTSESI HVSDVGHVEH VVHDSVVEAE IVTDPLAADV VSEEVLVADC
ASEAVIDANG IPVNQQDEEK NNCEDYLMIS LDDAGKIEHD GSSGLTMDNE TEIDPCKVDG
TCPEVIKVYI FKADPGEDDL GGTVDIVESE PENEHGVELL DPNNSIRVPR EKMVYMAVND
SQQEEEELNV AEIADEVYME VIVGEEDAAA AAAAAVHEQQ VEDNEMKTFM PIAWAAAYGN
NSDGIENRNG TASALLHIDE SAGLGRLAKQ KPKKRRRPDS RQYQTAIIIG PDGHPLTVYP
CMICGKKFKS RGFLKRHMKN HPEHLAKKKY RCTDCDYTTN KKISLHNHLE SHKLTSKAEK
AIECDECGKH FSHAGALFTH KMVHKEKGAN KMHKCKFCEY ETAEQGLLNR HLLAVHSKNF
PHICVECGKG FRHPSELKKH MRIHTGEKPY ECQYCEYRSA DSSNLKTHVK TKHSKEMPFK
CDICLLTFSD TKEVQQHALV HQESKTHQCL HCDHKSSNSS DLKRHIISVH TKDYPHKCDM
CDKGFHRPSE LKKHVAAHKG KKMHQCRHCD FKIADPFVLS RHILSVHTKD LPFRCKRCRK
GFRQQSELKK HMKTHSGRKV YQCEYCEYST TDASGFKRHV ISIHTKDYPH RCEYCKKGFR
RPSEKNQHIM RHHKEVGLP
