ZFX_PIG
ID ZFX_PIG Reviewed; 148 AA.
AC P80944;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Zinc finger X-chromosomal protein;
DE Flags: Fragment;
GN Name=ZFX;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Lymphocyte;
RA Pailhoux E.A., Pelliniemi L., Barbos A., Parma P., Kuopio T., Cotinot C.Y.;
RT "Relevance of intersexuality to breeding and reproductive biotechnology
RT programs; XX sex reversal in pigs.";
RL Theriogenology 47:93-102(1997).
CC -!- FUNCTION: Probable transcriptional activator.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. ZFX/ZFY subfamily. {ECO:0000305}.
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DR EMBL; X75510; CAA53221.1; -; Genomic_DNA.
DR PIR; S38660; S38660.
DR AlphaFoldDB; P80944; -.
DR SMR; P80944; -.
DR STRING; 9823.ENSSSCP00000012966; -.
DR PaxDb; P80944; -.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; P80944; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043035; F:chromatin insulator sequence binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN <1..>148
FT /note="Zinc finger X-chromosomal protein"
FT /id="PRO_0000047260"
FT ZN_FING 16..38
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 76..98
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT NON_TER 1
FT NON_TER 148
SQ SEQUENCE 148 AA; 17101 MW; 06E93C9DEE3DA6CD CRC64;
NHMESHKLTS KAEKAIECDE CGKHFSHAGA LFTHKMVHKE KGANKMHKCK FCEYETAEQG
LLNRHLLAVH SKNFPHICVE CGKGFRHPSE LKKHMRIHTG EKPYQCQYCE YRSADSSNLK
THVKTKHSKE MPFKCDICLL TFSDTKEV