ID   ZFY1_XENLA              Reviewed;         794 AA.
AC   Q01611;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Zinc finger Y-chromosomal protein 1;
DE            Short=ZFY-1;
GN   Name=zfy1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Oocyte;
RX   PubMed=1454548; DOI=10.1093/nar/20.21.5845;
RA   Connor F.A., Ashworth A.;
RT   "Sequence of cDNA for Xenopus XZFY-1.";
RL   Nucleic Acids Res. 20:5845-5845(1992).
CC   -!- FUNCTION: Probable transcriptional activator.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. ZFX/ZFY subfamily. {ECO:0000305}.
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DR   EMBL; X68024; CAA48165.1; -; mRNA.
DR   PIR; S26648; S26648.
DR   AlphaFoldDB; Q01611; -.
DR   SMR; Q01611; -.
DR   PRIDE; Q01611; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR006794; Transcrp_activ_Zfx/Zfy-dom.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   Pfam; PF04704; Zfx_Zfy_act; 1.
DR   SMART; SM00355; ZnF_C2H2; 13.
DR   SUPFAM; SSF57667; SSF57667; 7.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..794
FT                   /note="Zinc finger Y-chromosomal protein 1"
FT                   /id="PRO_0000047266"
FT   ZN_FING         411..433
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         442..464
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         477..499
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         508..531
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         537..559
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         565..588
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         594..616
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         622..645
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         651..673
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         679..702
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         708..730
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         736..759
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         765..788
FT                   /note="C2H2-type 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   MOTIF           380..389
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   794 AA;  89621 MW;  2A3624A67D8B394D CRC64;
     MEDVAELELQ TTEPHAFFHA SGVGERHLNG NEIIVEIQET VFVADGDGNM AVQGFGPDEG
     DSVVIQDVIE DVVIEDVQCS DILDGGRVSE AVIIPEQVLE DEVGTGEEEQ VLEEDSLTSC
     DVPDNVLDPE LVDGELTIPD PETGMHSVSG HVVIGEEITD DALEEDMISE EVLVADCVSE
     AVIDANGIPV HENDSEEVNC DDYLMISLDD AEKIDEDGAE EITMGSVVEG DSSKLDGSCP
     EVIKVYIFKA DPGEEDLGGT VDIVESESEN DHGDGFLDSH NGGRLPREKM VYMTVNDSQN
     DDDLDVAEIA DEVYMEVIVG EEDAAVAHEH QLEDAELSKT FMPVAWAAAY GNNTDGIEHR
     NGTASALLHI DESDGLDRLT KQKLKKKRRG ENRQYQTAII IGPDGHPLTV YPCMICGKKF
     KSRGFLKRHM KNHPEHLVRK KYRCTDCDYT TNKKVSLHNH LESHKLTATV IKTEKDLECE
     ECGKIFLHAN ALFAHKLTHN EKAGNKMHIC KFCDYETAEQ GLLNRHLLAV HSKSFPHICV
     ECGKGFRHPS ELKKHMRTHT GEKPYLCQYC DYRSADSSNL KTHVKTKHSK EMPFKCDICL
     QTFTDSKDLQ EHAILHQESK NHQCLHCDHK SSNSSDLKRH IISVHTKDYP HKCEVCEKGF
     HRPSELKKHE AAHKGKKMHQ CRHCEFHIAD PFVLSRHILS VHTKELPYRC KRCKKGFRQQ
     IELKKHMKTH SGKKVYQCEY CEYNTTDASG FKRHVISIHT KDYPHRCDYC KKGFRRPSEK
     NQHTLKHHKE ASLM