ZFY26_DROME
ID ZFY26_DROME Reviewed; 2243 AA.
AC Q9VGP1; Q86NZ0; Q961I5;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 3.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Zinc finger FYVE domain-containing protein 26 homolog;
GN ORFNames=CG5270;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 781-2243.
RC STRAIN=Berkeley; TISSUE=Larva, and Pupae;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1263-2243.
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-403 AND SER-1424, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- SIMILARITY: Belongs to the ZFYVE26 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK92994.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014297; AAF54635.3; -; Genomic_DNA.
DR EMBL; BT003566; AAO39570.1; -; mRNA.
DR EMBL; AY051570; AAK92994.1; ALT_INIT; mRNA.
DR RefSeq; NP_731570.2; NM_169389.3.
DR AlphaFoldDB; Q9VGP1; -.
DR SMR; Q9VGP1; -.
DR BioGRID; 66503; 4.
DR IntAct; Q9VGP1; 4.
DR STRING; 7227.FBpp0081863; -.
DR iPTMnet; Q9VGP1; -.
DR PaxDb; Q9VGP1; -.
DR PRIDE; Q9VGP1; -.
DR EnsemblMetazoa; FBtr0082387; FBpp0081863; FBgn0037897.
DR GeneID; 41370; -.
DR KEGG; dme:Dmel_CG5270; -.
DR UCSC; CG5270-RA; d. melanogaster.
DR UCSC; CG5270-RB; d. melanogaster.
DR FlyBase; FBgn0037897; CG5270.
DR VEuPathDB; VectorBase:FBgn0037897; -.
DR eggNOG; KOG1811; Eukaryota.
DR HOGENOM; CLU_230725_0_0_1; -.
DR InParanoid; Q9VGP1; -.
DR OMA; SYYTALC; -.
DR OrthoDB; 1237900at2759; -.
DR PhylomeDB; Q9VGP1; -.
DR BioGRID-ORCS; 41370; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 41370; -.
DR PRO; PR:Q9VGP1; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037897; Expressed in arthropod fat body and 25 other tissues.
DR ExpressionAtlas; Q9VGP1; baseline and differential.
DR Genevisible; Q9VGP1; DM.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0030496; C:midbody; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:InterPro.
DR GO; GO:0032465; P:regulation of cytokinesis; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR028730; ZFYVE26.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46591; PTHR46591; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..2243
FT /note="Zinc finger FYVE domain-containing protein 26
FT homolog"
FT /id="PRO_0000408353"
FT ZN_FING 1444..1505
FT /note="FYVE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT REGION 386..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1505..1534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..532
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1508..1534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1450
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 1453
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 1467
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 1470
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 1475
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 1478
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 1497
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 1500
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT MOD_RES 403
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1424
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT CONFLICT 1561
FT /note="V -> L (in Ref. 3; AAO39570)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2243 AA; 253674 MW; D6195C96818FB8FE CRC64;
MEDQQEENMQ QLLNLLPKDQ RQIFEIFIQW LNGKSSGPIQ LHQNALLTVL QASPYPALQL
LQLLHERSKL HIGQIISTLL RQLLDGDVAS PRSLCVLANF PASVLEASTL RQKLMTRLVV
DSITSEHLML TMLARSDGQL LDDLLHEQQL TMRAQCSEAA PTKLLVLWLA LNEREHFVAS
VCQHLKDFKC FQDVTLRNNL LILRLANEFA LGSQTLEELG CLEKLLAEFD VSAVPEKLQE
VHGFFYADFQ RLSTLLNFLR PREISKTLRV DALLRAPGVL PLIHENGIHF KHQELHRLIE
DTYKWQQLTP ALKCHHQEEV EILSYYTALC HVYDVVLDQG EQTTKTKLVQ LSVQLRQLHQ
LGALCSLLED IFLLVFLRWE QLEPNSQRKG EDGENDEEDD EQYVDDDVAS PPRPTAVHSQ
RTRYGFICRS ASLHALFTFL KAFVTKKIHS QDYKSAPEQQ GRFQRLVDAI SEALWKLGVL
QKIEQSLLKS APSISCLLEP DQLLQLVQLH STAKKKASSD DESRERSNHA SSLNRRKARR
QRRAVSFSGG VAGKASADGG LAMEQLRARA QLLSGSGSRK NSSVTSPCER SIIPKMLSTP
EQLAIMALAL KNFNDVKKII ETFHLEHSQL NRELHFMEQQ QLVKQKLSAI YANYQILEGQ
QANSGETTVE QIKGVAAKGF ELSKIISVVD NFSQAHRLQQ SPELKALIQR HNTSAQQGFL
QQFEERNLNA LIICDLIVNL GFNREITSNL LLVIRRQQQQ KKGGDEASNT PGSSELGAMN
LLQNLCECMR LLERSGQQAA LNELLSLKSY PLRPAVLALQ LQREAAFQTL YQKEPSEYSH
GHELRSNANQ FQQLRSRHNY YARFCTYVQQ LARLLQLRDP NLEYHTTQLL RNDPYEVIGE
LIYECGITPL EIEASVAALH LNLVHVIALN ICPQLSEEPT KRLPRVVAPQ KQESIHNYIS
QHNQLLAHIL LAIQLGSLPD GDADVDFSFL GHLVHLSEVN VLASVYDGNR VLAALNAYKL
ESARLDQLVT DQEQLLQILL LGMSGQTDSP NRHKSRIDQL IGDLIEKDPR NIHLVVHMGN
LGQRAQLLKE HFTRIPSSQQ AKELIERTLH HRSAAKSIPT ALRSELEHTL SDITIYARVS
ALLKFESWPQ AYDFGRQTPN VIFEQLLQRR RFGLCLEWSR VVYLAGSAGQ QRVCLLTLLD
ALLELRDGEE LDESLLGIVE MFPPNPLVNF LDTHKDKFRS LPLLQWVIDY LEGHARDPRL
YRNYQLSLEF LRQMDTNERS PFWKLIRHPL LIVEQLVMNA RFELLGKLLD AARSKLLKER
PLGPCPYCFD KTGHVYDVQS SAGLGSGAGE TPAKIRFQLG QTTSEAFILL NFNSYQQDHF
VGQDCLDLLL RIYASKALDY HVANVRAASE PSSLGTDVHN SLDSLCGAFV MPKQAPNRQQ
WTRDEEASHC MCCRRAAFTM LMRRHHCRRC GRVVCYACST HRIRIPELYD ELEVRICNDC
AACSTPAKDQ GDGTSSERSA ISGQVSKSSG RSDSCKWQLS GIITHDKLLR EEFSYEHAPS
VALSLSILRN HVEQRSCVDL LLFHCRKLEK LIVPNPEVDY GLVAKMINCL AFAAKVRGAP
GELENIREHS EIIMAVVQQG CESLIPTGPL NNHNLRKLAD ALVEAEHWTL ALEVHLKCGF
ATTGVMAAHG LACLRAGCYD AAREKFAHCM TRLSSEQLNS SICKNIFGVA STEAVLLPRK
RPQRGPALLQ EILQLIAAIP QVQTQPETLH RASLIRSSNT SLASLFTRRR EPYVQPRPLQ
EPALNIMNAL AGLKNLAKGQ YGGQMPTSEE SRRQERGFEE SLHYVLTYGS HADILTFLMR
REELRAALRY WQHQQLDADL FIHHIFYPQL ANGGLNVLMD ELQQLDDAQF TAWRLPLLQT
CRHLEQQQQL SSLYQLQLLL KDPIRASMTC VKFYALQCEN FQKLHANAQH LLSALRHLQG
ELDMAEWEHL QRQQARRNSV SSTASVRGAC FAMQMDARAL NGHINTIRRQ LEVAKFLDKC
EREQPPDEPL RTIQTLKQIR LESSRGTLPT LFEGAADRIQ ICILILMCGK NIDEGFGLAY
GIMQDFKLAA LKVFGATAKY LSRNQRLGEV ERLLDCIGSN NGGDISTESD EILSIAINAA
VHSSAPETKQ MLDRLIKRIG SVELRVSSYI YIGQLKSAYL LANKHDRLAD IRRILRQAEL
TGQVHIKKLC DMKLQLSAAP TPL
