ID   CC181_MACFA             Reviewed;         509 AA.
AC   Q4R6Q9;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Coiled-coil domain-containing protein 181 {ECO:0000250|UniProtKB:Q5TID7};
GN   Name=CCDC181 {ECO:0000250|UniProtKB:Q5TID7};
GN   ORFNames=QtsA-17368 {ECO:0000303|Ref.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Microtubule-binding protein that localizes to the
CC       microtubular manchette of elongating spermatids.
CC       {ECO:0000250|UniProtKB:Q80ZU5}.
CC   -!- SUBUNIT: Homodimer. Interacts with HOOK1. Interacts with HOOK2.
CC       Interacts with HOOK3. {ECO:0000250|UniProtKB:Q80ZU5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q80ZU5}. Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:Q80ZU5}. Note=Localizes to the microtubular
CC       manchette of elongating spermatids. Localizes to the sperm flagella and
CC       to the basal half of motile cilia. {ECO:0000250|UniProtKB:Q80ZU5}.
CC   -!- SIMILARITY: Belongs to the CCDC181 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB169121; BAE01215.1; -; mRNA.
DR   RefSeq; NP_001272244.1; NM_001285315.1.
DR   AlphaFoldDB; Q4R6Q9; -.
DR   SMR; Q4R6Q9; -.
DR   STRING; 9541.XP_005539985.1; -.
DR   GeneID; 101866740; -.
DR   CTD; 57821; -.
DR   eggNOG; ENOG502QV5R; Eukaryota.
DR   OrthoDB; 1520743at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0002177; C:manchette; ISS:UniProtKB.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   InterPro; IPR026687; CCDC181.
DR   InterPro; IPR025259; CCDC34/181.
DR   PANTHER; PTHR14320; PTHR14320; 1.
DR   Pfam; PF13904; DUF4207; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW   Microtubule; Reference proteome.
FT   CHAIN           1..509
FT                   /note="Coiled-coil domain-containing protein 181"
FT                   /id="PRO_0000279466"
FT   REGION          60..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          285..367
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          335..375
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        60..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        103..121
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        297..311
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..341
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..367
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   509 AA;  60026 MW;  46CAF92D813B00B2 CRC64;
     MNEIKDTDSK KSEEYEDDFE KDLEWLINEN EKSDASIIEM ACEKEENINQ DLKENETVIE
     HTKQHSDPDK SLQDDVSPRR NDIISVPGIQ PLDPISDSDS ENSFQESKLE SQKDLEEEED
     EEVRRYIMEK IVQANKLLQN QEPVNDKRER KLKFKDKLAD LEVPPLEDTN TSKNYFENER
     NMFGKLSQLC ISNDFGQENV LLSLTNASCE ENKDRTILVE RDGKFELLNL QDIASQGFLP
     PINNANSTEN DPQHLLLRSS NSSVSGTKKE DSAAKIHAVT HSSTGEPLVY IPQPPLNRKT
     CPSSAANSDR SKGKGKYNHR TQSARISPVT STYCLSPRQK ELQKQLEQKR EKLKREEEQR
     KIEEEKEKKR ENDIVFKAWL QKKREQVLEM RRIQRAKEIE DMNSRQENRD PQQAFRLWLK
     KKHEEQMKER KTEELRKQEE CLFFLKGTEG RERAFKQWLR RKRIEKIAEQ QAVRERTRQL
     RLEAKHSKQL QHHLYMSEAK PFRFTDHYN