ID   ZFY_BOVIN               Reviewed;         801 AA.
AC   Q95LI3;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Zinc finger Y-chromosomal protein;
GN   Name=ZFY;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Poloumienko A., Blecher S.;
RT   "Bovine ZFX and ZFY genes reveal extensive similarity to human zinc finger
RT   protein genes.";
RL   Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transcriptional activator. Binds to the consensus
CC       sequence 5'-AGGCCY-3' (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The binding of ZFY to DNA is mediated by the interaction of the
CC       GGCC core base pairs with zinc fingers 12 and 13. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. ZFX/ZFY subfamily. {ECO:0000305}.
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DR   EMBL; AF032867; AAL18261.1; -; mRNA.
DR   RefSeq; NP_803457.1; NM_177491.1.
DR   AlphaFoldDB; Q95LI3; -.
DR   SMR; Q95LI3; -.
DR   PRIDE; Q95LI3; -.
DR   GeneID; 280962; -.
DR   CTD; 7544; -.
DR   InParanoid; Q95LI3; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043035; F:chromatin insulator sequence binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR006794; Transcrp_activ_Zfx/Zfy-dom.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 6.
DR   Pfam; PF04704; Zfx_Zfy_act; 1.
DR   SMART; SM00355; ZnF_C2H2; 13.
DR   SUPFAM; SSF57667; SSF57667; 7.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..801
FT                   /note="Zinc finger Y-chromosomal protein"
FT                   /id="PRO_0000250510"
FT   ZN_FING         421..443
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         452..474
FT                   /note="C2H2-type 2; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         484..506
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         515..538
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         544..566
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         572..595
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         601..623
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         629..652
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         658..680
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         686..709
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         715..737
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         743..766
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         772..795
FT                   /note="C2H2-type 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   MOD_RES         269
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P17012"
SQ   SEQUENCE   801 AA;  90344 MW;  2E34555E4653BE96 CRC64;
     MDEDEFELQP QEPNSCFDGI GTDATHMDGD QIVVEVQETV FVSDVVDSDI TVHNFVPDDP
     DSVVIQDVIE NVVIEDVQCS DILEEADVSE NVIIPEQMLS SDVTEEVSLA HCTVPDDVLA
     SDITSASMSM PEHVLTSESV HVSDVGHVEH IVHGSVVEAE IVTDPLTADV VSEEVLVADC
     ASEAVIDANG IPVDQQDDDK GNCEDYLMIS LDDDGKMEHD CSSGMTMDAE SEIDPCKVDG
     TCPEVIKVYI FKADPGEDDL GGTVDIVESE PENDHGVELL DQNNSIRMPR EKMVYMTVND
     SQQEDEDLNV AEIADEVYME VIVGEEDAAV AAAAATTVHE QEMDDSEIKT FMPIAWAAAY
     GNNSDGIENR SGTASALLHI DESAGLGRLT KHKPKKRRRP DSRQYQTAII IGPDGHPLTV
     YPCMICGKKF KSRGFLKRHM KNHPEHLTKK KYRCTDCDYT TNKKISLHNH LESHKLTSKS
     EKAIECDDCG KHFSHAGALF THKMVHKEKG ASKMHKCKFC EYETAEQGLL NRHLLAVHSK
     NFPHICVECG KGFRHPSELK KHMRIHTGEK PYQCQYCEYR SADSSNLKTH VKTKHSKEMS
     FKCDICLLTF SDTKEVQQHA LIHQESKTHQ CVHCDHKSSN SSDLKRHIIS VHTKDYPHKC
     DMCDKGFHRP SELKKHVAAH KGKKMHQCRH CDFKIADPFV LSRHILSVHT KDLPFRCKRC
     KKGFRQQNEL KKHMKTHSGR KVYQCEYCEY STTDASGFKR HVISIHTKDY PHRCEYCKKG
     FRRPSEKNQH ITRHHKEVGL P