ID   ZFY_PIG                 Reviewed;         148 AA.
AC   Q29419;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Zinc finger Y-chromosomal protein;
DE   Flags: Fragment;
GN   Name=ZFY;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Lymphocyte;
RA   Pailhoux E.A., Pelliniemi L., Barbos A., Parma P., Kuopio T., Cotinot C.Y.;
RT   "Relevance of intersexuality to breeding and reproductive biotechnology
RT   programs; XX sex reversal in pigs.";
RL   Theriogenology 47:93-102(1997).
CC   -!- FUNCTION: Probable transcriptional activator. Binds to the consensus
CC       sequence 5'-AGGCCY-3' (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: The binding of ZFY to DNA is mediated by the interaction of the
CC       GGCC core base pairs with zinc fingers 12 and 13. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. ZFX/ZFY subfamily. {ECO:0000305}.
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DR   EMBL; X75511; CAA53222.1; -; Genomic_DNA.
DR   PIR; S38660; S38660.
DR   AlphaFoldDB; Q29419; -.
DR   SMR; Q29419; -.
DR   InParanoid; Q29419; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043035; F:chromatin insulator sequence binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           <1..>148
FT                   /note="Zinc finger Y-chromosomal protein"
FT                   /id="PRO_0000047265"
FT   ZN_FING         16..38
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         76..98
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   NON_TER         1
FT   NON_TER         148
SQ   SEQUENCE   148 AA;  17101 MW;  06E93C9DEE3DA6CD CRC64;
     NHMESHKLTS KAEKAIECDE CGKHFSHAGA LFTHKMVHKE KGANKMHKCK FCEYETAEQG
     LLNRHLLAVH SKNFPHICVE CGKGFRHPSE LKKHMRIHTG EKPYQCQYCE YRSADSSNLK
     THVKTKHSKE MPFKCDICLL TFSDTKEV