ZG16B_HUMAN
ID ZG16B_HUMAN Reviewed; 208 AA.
AC Q96DA0; A6NIY1; B2R4F6; Q6UW28;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 3.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Zymogen granule protein 16 homolog B;
DE Flags: Precursor;
GN Name=ZG16B; ORFNames=UNQ773/PRO1567;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung carcinoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-208.
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=11678034;
RX DOI=10.1002/1615-9861(200104)1:5<641::aid-prot641>3.0.co;2-r;
RA Kuster B., Mortensen P., Andersen J.S., Mann M.;
RT "Mass spectrometry allows direct identification of proteins in large
RT genomes.";
RL Proteomics 1:641-650(2001).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 53-208.
RX PubMed=21110947; DOI=10.1016/j.bbrc.2010.11.093;
RA Kanagawa M., Satoh T., Ikeda A., Nakano Y., Yagi H., Kato K.,
RA Kojima-Aikawa K., Yamaguchi Y.;
RT "Crystal structures of human secretory proteins ZG16p and ZG16b reveal a
RT Jacalin-related beta-prism fold.";
RL Biochem. Biophys. Res. Commun. 404:201-205(2011).
CC -!- INTERACTION:
CC Q96DA0; Q9BT25: HAUS8; NbExp=3; IntAct=EBI-953824, EBI-2558143;
CC Q96DA0; Q9UJW9: SERTAD3; NbExp=5; IntAct=EBI-953824, EBI-748621;
CC Q96DA0; O43765: SGTA; NbExp=3; IntAct=EBI-953824, EBI-347996;
CC Q96DA0; Q96EQ0: SGTB; NbExp=5; IntAct=EBI-953824, EBI-744081;
CC Q96DA0; Q9BSL1: UBAC1; NbExp=3; IntAct=EBI-953824, EBI-749370;
CC Q96DA0; Q9UHD9: UBQLN2; NbExp=6; IntAct=EBI-953824, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the jacalin lectin family. {ECO:0000255|PROSITE-
CC ProRule:PRU01088, ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1, Met-13 or Met-31 is the
CC initiator. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ89380.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAG34753.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY359021; AAQ89380.1; ALT_INIT; mRNA.
DR EMBL; AC005361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471112; EAW85462.1; -; Genomic_DNA.
DR EMBL; BC009722; AAH09722.2; -; mRNA.
DR EMBL; AK311810; BAG34753.1; ALT_INIT; mRNA.
DR RefSeq; NP_660295.2; NM_145252.2.
DR PDB; 3AQG; X-ray; 2.75 A; A/B=53-208.
DR PDBsum; 3AQG; -.
DR AlphaFoldDB; Q96DA0; -.
DR SMR; Q96DA0; -.
DR BioGRID; 125855; 190.
DR IntAct; Q96DA0; 46.
DR MINT; Q96DA0; -.
DR STRING; 9606.ENSP00000371715; -.
DR GlyConnect; 1909; 6 N-Linked glycans (1 site).
DR GlyGen; Q96DA0; 1 site, 6 N-linked glycans (1 site).
DR iPTMnet; Q96DA0; -.
DR PhosphoSitePlus; Q96DA0; -.
DR BioMuta; ZG16B; -.
DR DMDM; 152031723; -.
DR EPD; Q96DA0; -.
DR jPOST; Q96DA0; -.
DR MassIVE; Q96DA0; -.
DR MaxQB; Q96DA0; -.
DR PaxDb; Q96DA0; -.
DR PeptideAtlas; Q96DA0; -.
DR PRIDE; Q96DA0; -.
DR ProteomicsDB; 76263; -.
DR Antibodypedia; 23906; 109 antibodies from 17 providers.
DR DNASU; 124220; -.
DR Ensembl; ENST00000382280.8; ENSP00000371715.4; ENSG00000162078.12.
DR Ensembl; ENST00000634500.1; ENSP00000489035.1; ENSG00000283056.1.
DR GeneID; 124220; -.
DR KEGG; hsa:124220; -.
DR UCSC; uc002cru.4; human.
DR CTD; 124220; -.
DR DisGeNET; 124220; -.
DR GeneCards; ZG16B; -.
DR HGNC; HGNC:30456; ZG16B.
DR HPA; ENSG00000162078; Tissue enriched (salivary).
DR neXtProt; NX_Q96DA0; -.
DR PharmGKB; PA164727732; -.
DR VEuPathDB; HostDB:ENSG00000162078; -.
DR eggNOG; ENOG502SWMW; Eukaryota.
DR InParanoid; Q96DA0; -.
DR OMA; GQIFSAY; -.
DR OrthoDB; 1317341at2759; -.
DR PhylomeDB; Q96DA0; -.
DR TreeFam; TF333440; -.
DR PathwayCommons; Q96DA0; -.
DR SignaLink; Q96DA0; -.
DR BioGRID-ORCS; 124220; 8 hits in 1070 CRISPR screens.
DR ChiTaRS; ZG16B; human.
DR GeneWiki; LOC124220; -.
DR GenomeRNAi; 124220; -.
DR Pharos; Q96DA0; Tbio.
DR PRO; PR:Q96DA0; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96DA0; protein.
DR Bgee; ENSG00000162078; Expressed in olfactory segment of nasal mucosa and 85 other tissues.
DR ExpressionAtlas; Q96DA0; baseline and differential.
DR Genevisible; Q96DA0; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0001895; P:retina homeostasis; HEP:UniProtKB.
DR Gene3D; 2.100.10.30; -; 1.
DR InterPro; IPR001229; Jacalin-like_lectin_dom.
DR InterPro; IPR036404; Jacalin-like_lectin_dom_sf.
DR Pfam; PF01419; Jacalin; 1.
DR SMART; SM00915; Jacalin; 1.
DR SUPFAM; SSF51101; SSF51101; 1.
DR PROSITE; PS51752; JACALIN_LECTIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Glycoprotein; Lectin; Reference proteome; Secreted; Signal.
FT SIGNAL 1..52
FT /evidence="ECO:0000255"
FT CHAIN 53..208
FT /note="Zymogen granule protein 16 homolog B"
FT /id="PRO_0000248073"
FT DOMAIN 53..185
FT /note="Jacalin-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01088"
FT CARBOHYD 197
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 133
FT /note="M -> V (in dbSNP:rs35533993)"
FT /id="VAR_060067"
FT STRAND 56..58
FT /evidence="ECO:0007829|PDB:3AQG"
FT STRAND 61..65
FT /evidence="ECO:0007829|PDB:3AQG"
FT STRAND 74..81
FT /evidence="ECO:0007829|PDB:3AQG"
FT STRAND 83..97
FT /evidence="ECO:0007829|PDB:3AQG"
FT STRAND 106..112
FT /evidence="ECO:0007829|PDB:3AQG"
FT STRAND 119..137
FT /evidence="ECO:0007829|PDB:3AQG"
FT STRAND 142..146
FT /evidence="ECO:0007829|PDB:3AQG"
FT STRAND 150..155
FT /evidence="ECO:0007829|PDB:3AQG"
FT STRAND 163..172
FT /evidence="ECO:0007829|PDB:3AQG"
FT STRAND 175..184
FT /evidence="ECO:0007829|PDB:3AQG"
SQ SEQUENCE 208 AA; 22739 MW; 313B0ED64B24CDB2 CRC64;
MGAQGAQESI KAMWRVPGTT RRPVTGESPG MHRPEAMLLL LTLALLGGPT WAGKMYGPGG
GKYFSTTEDY DHEITGLRVS VGLLLVKSVQ VKLGDSWDVK LGALGGNTQE VTLQPGEYIT
KVFVAFQAFL RGMVMYTSKD RYFYFGKLDG QISSAYPSQE GQVLVGIYGQ YQLLGIKSIG
FEWNYPLEEP TTEPPVNLTY SANSPVGR
