ID   CC181_PONAB             Reviewed;         509 AA.
AC   Q5NVK0;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Coiled-coil domain-containing protein 181 {ECO:0000250|UniProtKB:Q5TID7};
GN   Name=CCDC181 {ECO:0000250|UniProtKB:Q5TID7};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Microtubule-binding protein that localizes to the
CC       microtubular manchette of elongating spermatids.
CC       {ECO:0000250|UniProtKB:Q80ZU5}.
CC   -!- SUBUNIT: Homodimer. Interacts with HOOK1. Interacts with HOOK2.
CC       Interacts with HOOK3. {ECO:0000250|UniProtKB:Q80ZU5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q80ZU5}. Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:Q80ZU5}. Note=Localizes to the microtubular
CC       manchette of elongating spermatids. Localizes to the sperm flagella and
CC       to the basal half of motile cilia. {ECO:0000250|UniProtKB:Q80ZU5}.
CC   -!- SIMILARITY: Belongs to the CCDC181 family. {ECO:0000305}.
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DR   EMBL; CR926026; CAI29663.1; -; mRNA.
DR   RefSeq; NP_001127687.1; NM_001134215.1.
DR   AlphaFoldDB; Q5NVK0; -.
DR   SMR; Q5NVK0; -.
DR   STRING; 9601.ENSPPYP00000000619; -.
DR   GeneID; 100174769; -.
DR   KEGG; pon:100174769; -.
DR   CTD; 57821; -.
DR   eggNOG; ENOG502QV5R; Eukaryota.
DR   InParanoid; Q5NVK0; -.
DR   OrthoDB; 1520743at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0002177; C:manchette; ISS:UniProtKB.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   InterPro; IPR026687; CCDC181.
DR   PANTHER; PTHR14320; PTHR14320; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW   Microtubule; Reference proteome.
FT   CHAIN           1..509
FT                   /note="Coiled-coil domain-containing protein 181"
FT                   /id="PRO_0000279468"
FT   REGION          58..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          241..332
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          345..367
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          335..375
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        58..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        103..120
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        241..269
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        297..332
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   509 AA;  59897 MW;  C5CC480E339EDE88 CRC64;
     MNEDKDTDSK KSEEYEDDFE KDLEWLINEN EKSDASIIEM ACEKEENINQ DLKENETVIE
     HTKQHSDPDK SLQDEVSPRK NDIISVPGIQ PLDPISDSDS ENSFQESRLE SQKDLEEEED
     EEVRRYIMEK IVQANKLLQN QEPVNDKRER KLKFEDKLVD LEVPPLEDTT TSKNYFENER
     NMFGKLSQLC ISNDFGQENV LLSLTNVSCE ENKDRTILVE RDGKFELLNL QDIASQGFLP
     PINNANTTEN DPQQLLPRSS NSSVSGTKKE DSAAKIHAVT HSSTGKPLAY IPQPPLNRKT
     CPSSAVISDQ SKGNGNSNHR AQSAHISPVT STCCLSPRQK ELQKQLEQKR EKLKREEERR
     KIEEEKEKKR ENDIVFKAWL QKKREQVLEM RRIQRAKEIE DMNSRQENRD PQQAFRLWLK
     KKHEEQMKER QTEELRKQEE CLFFLKGTEG RERAFKQWLR RKRIEKMAEQ QAVRERTRQL
     RLEAKRSKQL QHHLYMSEAK PFRFTDHYN