ZG16_MOUSE
ID ZG16_MOUSE Reviewed; 167 AA.
AC Q8K0C5;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Zymogen granule membrane protein 16;
DE Short=Zymogen granule protein 16;
DE AltName: Full=Secretory lectin ZG16;
DE Flags: Precursor;
GN Name=Zg16;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver, Lung, Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in protein trafficking. May act as a linker
CC molecule between the submembranous matrix on the luminal side of
CC zymogen granule membrane (ZGM) and aggregated secretory proteins during
CC granule formation in the TGN (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250|UniProtKB:O60844}. Zymogen granule lumen
CC {ECO:0000250|UniProtKB:Q8CJD3}. Golgi apparatus lumen
CC {ECO:0000250|UniProtKB:Q8CJD3}.
CC -!- SIMILARITY: Belongs to the jacalin lectin family. {ECO:0000255|PROSITE-
CC ProRule:PRU01088, ECO:0000305}.
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DR EMBL; BC031800; AAH31800.1; -; mRNA.
DR CCDS; CCDS21856.1; -.
DR RefSeq; NP_081194.1; NM_026918.2.
DR RefSeq; XP_006508238.1; XM_006508175.3.
DR AlphaFoldDB; Q8K0C5; -.
DR SMR; Q8K0C5; -.
DR STRING; 10090.ENSMUSP00000056916; -.
DR iPTMnet; Q8K0C5; -.
DR PhosphoSitePlus; Q8K0C5; -.
DR PaxDb; Q8K0C5; -.
DR PeptideAtlas; Q8K0C5; -.
DR PRIDE; Q8K0C5; -.
DR ProteomicsDB; 275366; -.
DR Antibodypedia; 43439; 94 antibodies from 17 providers.
DR DNASU; 69036; -.
DR Ensembl; ENSMUST00000051122; ENSMUSP00000056916; ENSMUSG00000049350.
DR Ensembl; ENSMUST00000205424; ENSMUSP00000145876; ENSMUSG00000049350.
DR GeneID; 69036; -.
DR KEGG; mmu:69036; -.
DR UCSC; uc009jue.1; mouse.
DR CTD; 653808; -.
DR MGI; MGI:1916286; Zg16.
DR VEuPathDB; HostDB:ENSMUSG00000049350; -.
DR eggNOG; ENOG502S4MA; Eukaryota.
DR GeneTree; ENSGT00940000159195; -.
DR HOGENOM; CLU_104246_0_0_1; -.
DR InParanoid; Q8K0C5; -.
DR OMA; HWDSYPS; -.
DR OrthoDB; 1305607at2759; -.
DR PhylomeDB; Q8K0C5; -.
DR TreeFam; TF333440; -.
DR BioGRID-ORCS; 69036; 4 hits in 71 CRISPR screens.
DR ChiTaRS; Zg16; mouse.
DR PRO; PR:Q8K0C5; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8K0C5; protein.
DR Bgee; ENSMUSG00000049350; Expressed in left colon and 158 other tissues.
DR ExpressionAtlas; Q8K0C5; baseline and differential.
DR Genevisible; Q8K0C5; MM.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005796; C:Golgi lumen; ISS:UniProtKB.
DR GO; GO:0070701; C:mucus layer; IDA:MGI.
DR GO; GO:0042589; C:zymogen granule membrane; ISO:MGI.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0042834; F:peptidoglycan binding; IDA:MGI.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IMP:MGI.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0052373; P:suppression of symbiont entry into host; IMP:MGI.
DR Gene3D; 2.100.10.30; -; 1.
DR InterPro; IPR001229; Jacalin-like_lectin_dom.
DR InterPro; IPR036404; Jacalin-like_lectin_dom_sf.
DR InterPro; IPR033563; ZG16.
DR PANTHER; PTHR33589:SF4; PTHR33589:SF4; 1.
DR Pfam; PF01419; Jacalin; 1.
DR SMART; SM00915; Jacalin; 1.
DR SUPFAM; SSF51101; SSF51101; 1.
DR PROSITE; PS51752; JACALIN_LECTIN; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Extracellular matrix; Golgi apparatus; Lectin;
KW Protein transport; Reference proteome; Secreted; Signal; Transport.
FT SIGNAL 1..16
FT /evidence="ECO:0000250"
FT CHAIN 17..167
FT /note="Zymogen granule membrane protein 16"
FT /id="PRO_0000017571"
FT DOMAIN 24..159
FT /note="Jacalin-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01088"
SQ SEQUENCE 167 AA; 18210 MW; C1D42C5468B86475 CRC64;
MLAVALLVLL CASASANSIQ SRTSSYSGEY GGKGGKRFSH SGNQLDGPIT AFRIRVNRYY
IVGLQVRYGT VWSDYVGGTQ GDLEEIFLHP GESVIQVSGK YKSYVKQMIF VTDKGRYLPF
GKASGTSFNA VPLHPNTVLR FISGRSGSAI DSISLHWDTY PSHCNTC
