ID   ZG16_RAT                Reviewed;         167 AA.
AC   Q8CJD3; Q63680;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Zymogen granule membrane protein 16;
DE            Short=Zymogen granule protein 16;
DE   AltName: Full=Secretory lectin ZG16;
DE   Flags: Precursor;
GN   Name=Zg16;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RC   STRAIN=Wistar; TISSUE=Pancreas;
RX   PubMed=7720729;
RA   Cronshagen U., Voland P., Kern H.-F.;
RT   "cDNA cloning and characterization of a novel 16 kDa protein located in
RT   zymogen granules of rat pancreas and goblet cells of the gut.";
RL   Eur. J. Cell Biol. 65:366-377(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Matsuda Y., Kojima-Aikawa K.;
RT   "Expression of rat ZG16p in AR42J cells.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=10099930; DOI=10.1016/s0171-9335(99)80009-0;
RA   Kleene R., Dartsch H., Kern H.-F.;
RT   "The secretory lectin ZG16p mediates sorting of enzyme proteins to the
RT   zymogen granule membrane in pancreatic acinar cells.";
RL   Eur. J. Cell Biol. 78:79-90(1999).
CC   -!- FUNCTION: May play a role in protein trafficking. May act as a linker
CC       molecule between the submembranous matrix on the luminal side of
CC       zymogen granule membrane (ZGM) and aggregated secretory proteins during
CC       granule formation in the TGN. {ECO:0000269|PubMed:10099930}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250|UniProtKB:O60844}. Zymogen granule lumen
CC       {ECO:0000269|PubMed:10099930, ECO:0000269|PubMed:7720729}. Golgi
CC       apparatus lumen {ECO:0000269|PubMed:10099930}.
CC   -!- TISSUE SPECIFICITY: Expressed in pancreas, colon, duodenum, and much
CC       less in stomach. {ECO:0000269|PubMed:7720729}.
CC   -!- SIMILARITY: Belongs to the jacalin lectin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01088, ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA83059.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; Z30584; CAA83059.1; ALT_FRAME; mRNA.
DR   EMBL; AB095177; BAC24023.1; -; mRNA.
DR   PIR; S42924; S42924.
DR   RefSeq; NP_599236.2; NM_134409.2.
DR   AlphaFoldDB; Q8CJD3; -.
DR   SMR; Q8CJD3; -.
DR   STRING; 10116.ENSRNOP00000022758; -.
DR   PaxDb; Q8CJD3; -.
DR   PRIDE; Q8CJD3; -.
DR   Ensembl; ENSRNOT00000022758; ENSRNOP00000022758; ENSRNOG00000016857.
DR   GeneID; 171449; -.
DR   KEGG; rno:171449; -.
DR   UCSC; RGD:620346; rat.
DR   CTD; 653808; -.
DR   RGD; 620346; Zg16.
DR   eggNOG; ENOG502S4MA; Eukaryota.
DR   GeneTree; ENSGT00940000159195; -.
DR   HOGENOM; CLU_104246_0_0_1; -.
DR   InParanoid; Q8CJD3; -.
DR   OMA; HWDSYPS; -.
DR   OrthoDB; 1305607at2759; -.
DR   PhylomeDB; Q8CJD3; -.
DR   TreeFam; TF333440; -.
DR   PRO; PR:Q8CJD3; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000016857; Expressed in jejunum and 13 other tissues.
DR   Genevisible; Q8CJD3; RN.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005796; C:Golgi lumen; ISS:UniProtKB.
DR   GO; GO:0070701; C:mucus layer; ISO:RGD.
DR   GO; GO:0042589; C:zymogen granule membrane; IDA:RGD.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0042834; F:peptidoglycan binding; ISO:RGD.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:RGD.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0052373; P:suppression of symbiont entry into host; ISO:RGD.
DR   Gene3D; 2.100.10.30; -; 1.
DR   InterPro; IPR001229; Jacalin-like_lectin_dom.
DR   InterPro; IPR036404; Jacalin-like_lectin_dom_sf.
DR   InterPro; IPR033563; ZG16.
DR   PANTHER; PTHR33589:SF4; PTHR33589:SF4; 1.
DR   Pfam; PF01419; Jacalin; 1.
DR   SMART; SM00915; Jacalin; 1.
DR   SUPFAM; SSF51101; SSF51101; 1.
DR   PROSITE; PS51752; JACALIN_LECTIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Extracellular matrix; Golgi apparatus; Lectin;
KW   Protein transport; Reference proteome; Secreted; Signal; Transport.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000250"
FT   CHAIN           17..167
FT                   /note="Zymogen granule membrane protein 16"
FT                   /id="PRO_0000017572"
FT   DOMAIN          24..159
FT                   /note="Jacalin-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01088"
FT   CONFLICT        80..83
FT                   /note="QGDL -> RET (in Ref. 1; CAA83059)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   167 AA;  18213 MW;  5C210CD2C1220CF2 CRC64;
     MLAIALLVLL CASASANSIQ SRSSSYSGEY GGKGGKRFSH SGNQLDGPIT AIRIRVNRYY
     IIGLQVRYGT VWSDYVGGNQ GDLEEIFLHP GESVIQVSGK YKSYVKQLIF VTDKGRYLPF
     GKDSGTSFNA VPLHPNTVLR FISGRSGSAI DAISLHWDTY PSHCNTC