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CC181_RAT
ID   CC181_RAT               Reviewed;         509 AA.
AC   Q6AYN9;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Coiled-coil domain-containing protein 181 {ECO:0000305};
GN   Name=Ccdc181 {ECO:0000312|RGD:1309708};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Microtubule-binding protein that localizes to the
CC       microtubular manchette of elongating spermatids.
CC       {ECO:0000250|UniProtKB:Q80ZU5}.
CC   -!- SUBUNIT: Homodimer. Interacts with HOOK1. Interacts with HOOK2.
CC       Interacts with HOOK3. {ECO:0000250|UniProtKB:Q80ZU5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q80ZU5}. Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:Q80ZU5}. Note=Localizes to the microtubular
CC       manchette of elongating spermatids. Localizes to the sperm flagella and
CC       to the basal half of motile cilia. {ECO:0000250|UniProtKB:Q80ZU5}.
CC   -!- SIMILARITY: Belongs to the CCDC181 family. {ECO:0000305}.
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DR   EMBL; BC078972; AAH78972.1; -; mRNA.
DR   RefSeq; NP_001014153.1; NM_001014131.1.
DR   AlphaFoldDB; Q6AYN9; -.
DR   SMR; Q6AYN9; -.
DR   STRING; 10116.ENSRNOP00000003844; -.
DR   PaxDb; Q6AYN9; -.
DR   PRIDE; Q6AYN9; -.
DR   Ensembl; ENSRNOT00000003844; ENSRNOP00000003844; ENSRNOG00000002860.
DR   GeneID; 360867; -.
DR   KEGG; rno:360867; -.
DR   UCSC; RGD:1309708; rat.
DR   CTD; 57821; -.
DR   RGD; 1309708; Ccdc181.
DR   eggNOG; ENOG502QV5R; Eukaryota.
DR   GeneTree; ENSGT00390000018244; -.
DR   HOGENOM; CLU_040811_0_0_1; -.
DR   InParanoid; Q6AYN9; -.
DR   OMA; FKAWLMR; -.
DR   OrthoDB; 1520743at2759; -.
DR   PhylomeDB; Q6AYN9; -.
DR   TreeFam; TF331115; -.
DR   PRO; PR:Q6AYN9; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000002860; Expressed in testis and 19 other tissues.
DR   Genevisible; Q6AYN9; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0002177; C:manchette; ISS:UniProtKB.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   InterPro; IPR026687; CCDC181.
DR   InterPro; IPR025259; CCDC34/181.
DR   PANTHER; PTHR14320; PTHR14320; 1.
DR   Pfam; PF13904; DUF4207; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW   Microtubule; Reference proteome.
FT   CHAIN           1..509
FT                   /note="Coiled-coil domain-containing protein 181"
FT                   /id="PRO_0000279469"
FT   REGION          27..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          287..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          335..377
FT                   /evidence="ECO:0000255"
FT   COILED          418..488
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        36..80
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        103..122
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..338
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..368
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   509 AA;  59291 MW;  ECB672471661238A CRC64;
     MDEDKGIDSK ESGEYEDDFE KDLEWLINDK EKSNGSMIEV ACKKEDDLDQ ELKEKETETE
     LGPQLSDPDK PPKDEALPRR NDFISVPSIQ PLDPISDSDS ENSFQDSKPE NQKDLEDEED
     EEVRRYIMEK IIEANKLLQT QEPVNDKRER KLKFKDKLVD LEVPPLEDSD TCKVLLENET
     NMSGKLSQLC ISGDLGQESM LMSVTNGGCE ENDRKILVER DGKFELMNLQ DIESQGFLPP
     ISSANGMEHE SSQLPLRSAN LSVGGIKKEE PEAKIHIMTL SQAGEPLAQV PQPPANPKNR
     PSSAANPDLN KKTRRSSHRI QSAGVSPVTS TYCLSPRQKE LQKQLERKRE RLKREEEQRK
     LEEENEKKKE NEMVFKAWLQ KKREQVVEMR RVQRAKQIED MSSRQVNRDP QQAFRLWLKK
     KHEEQMKERK TEELRKQEEC LFFLRGTEGR ERAFRQWLRR KQIEKIAEQQ AVKERARQLR
     LEARRSKQLQ SGLYSVPEAK AFRFTDHYN
 
 
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