CC181_RAT
ID CC181_RAT Reviewed; 509 AA.
AC Q6AYN9;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Coiled-coil domain-containing protein 181 {ECO:0000305};
GN Name=Ccdc181 {ECO:0000312|RGD:1309708};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Microtubule-binding protein that localizes to the
CC microtubular manchette of elongating spermatids.
CC {ECO:0000250|UniProtKB:Q80ZU5}.
CC -!- SUBUNIT: Homodimer. Interacts with HOOK1. Interacts with HOOK2.
CC Interacts with HOOK3. {ECO:0000250|UniProtKB:Q80ZU5}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q80ZU5}. Cell projection, cilium, flagellum
CC {ECO:0000250|UniProtKB:Q80ZU5}. Note=Localizes to the microtubular
CC manchette of elongating spermatids. Localizes to the sperm flagella and
CC to the basal half of motile cilia. {ECO:0000250|UniProtKB:Q80ZU5}.
CC -!- SIMILARITY: Belongs to the CCDC181 family. {ECO:0000305}.
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DR EMBL; BC078972; AAH78972.1; -; mRNA.
DR RefSeq; NP_001014153.1; NM_001014131.1.
DR AlphaFoldDB; Q6AYN9; -.
DR SMR; Q6AYN9; -.
DR STRING; 10116.ENSRNOP00000003844; -.
DR PaxDb; Q6AYN9; -.
DR PRIDE; Q6AYN9; -.
DR Ensembl; ENSRNOT00000003844; ENSRNOP00000003844; ENSRNOG00000002860.
DR GeneID; 360867; -.
DR KEGG; rno:360867; -.
DR UCSC; RGD:1309708; rat.
DR CTD; 57821; -.
DR RGD; 1309708; Ccdc181.
DR eggNOG; ENOG502QV5R; Eukaryota.
DR GeneTree; ENSGT00390000018244; -.
DR HOGENOM; CLU_040811_0_0_1; -.
DR InParanoid; Q6AYN9; -.
DR OMA; FKAWLMR; -.
DR OrthoDB; 1520743at2759; -.
DR PhylomeDB; Q6AYN9; -.
DR TreeFam; TF331115; -.
DR PRO; PR:Q6AYN9; -.
DR Proteomes; UP000002494; Chromosome 13.
DR Bgee; ENSRNOG00000002860; Expressed in testis and 19 other tissues.
DR Genevisible; Q6AYN9; RN.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0002177; C:manchette; ISS:UniProtKB.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR InterPro; IPR026687; CCDC181.
DR InterPro; IPR025259; CCDC34/181.
DR PANTHER; PTHR14320; PTHR14320; 1.
DR Pfam; PF13904; DUF4207; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW Microtubule; Reference proteome.
FT CHAIN 1..509
FT /note="Coiled-coil domain-containing protein 181"
FT /id="PRO_0000279469"
FT REGION 27..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 335..377
FT /evidence="ECO:0000255"
FT COILED 418..488
FT /evidence="ECO:0000255"
FT COMPBIAS 36..80
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..368
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 509 AA; 59291 MW; ECB672471661238A CRC64;
MDEDKGIDSK ESGEYEDDFE KDLEWLINDK EKSNGSMIEV ACKKEDDLDQ ELKEKETETE
LGPQLSDPDK PPKDEALPRR NDFISVPSIQ PLDPISDSDS ENSFQDSKPE NQKDLEDEED
EEVRRYIMEK IIEANKLLQT QEPVNDKRER KLKFKDKLVD LEVPPLEDSD TCKVLLENET
NMSGKLSQLC ISGDLGQESM LMSVTNGGCE ENDRKILVER DGKFELMNLQ DIESQGFLPP
ISSANGMEHE SSQLPLRSAN LSVGGIKKEE PEAKIHIMTL SQAGEPLAQV PQPPANPKNR
PSSAANPDLN KKTRRSSHRI QSAGVSPVTS TYCLSPRQKE LQKQLERKRE RLKREEEQRK
LEEENEKKKE NEMVFKAWLQ KKREQVVEMR RVQRAKQIED MSSRQVNRDP QQAFRLWLKK
KHEEQMKERK TEELRKQEEC LFFLRGTEGR ERAFRQWLRR KQIEKIAEQQ AVKERARQLR
LEARRSKQLQ SGLYSVPEAK AFRFTDHYN