ID   ZG53_XENLA              Reviewed;         516 AA.
AC   P18728;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Gastrula zinc finger protein XlCGF53.1;
DE   Flags: Fragment;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-334.
RX   PubMed=2503827; DOI=10.1073/pnas.86.16.6097;
RA   Knoechel W., Poeting A., Koester M., el Baradi T., Nietfeld W.,
RA   Bouwmeester T., Pieler T.;
RT   "Evolutionary conserved modules associated with zinc fingers in Xenopus
RT   laevis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:6097-6100(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 307-516.
RX   PubMed=2509712; DOI=10.1016/0022-2836(89)90155-1;
RA   Nietfeld W., El-Baradi T., Mentzel H., Pieler T., Koester M., Poeting A.,
RA   Knoechel W.;
RT   "Second-order repeats in Xenopus laevis finger proteins.";
RL   J. Mol. Biol. 208:639-659(1989).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M25872; AAA50019.1; -; mRNA.
DR   PIR; G33282; G33282.
DR   PIR; S06577; S06577.
DR   AlphaFoldDB; P18728; -.
DR   SMR; P18728; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 6.
DR   SMART; SM00355; ZnF_C2H2; 7.
DR   SUPFAM; SSF57667; SSF57667; 4.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..>516
FT                   /note="Gastrula zinc finger protein XlCGF53.1"
FT                   /id="PRO_0000047800"
FT   ZN_FING         312..334
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         354..376
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         382..404
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         410..432
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         438..460
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         466..488
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         494..516
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          200..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         516
SQ   SEQUENCE   516 AA;  58374 MW;  404C93C0444EE4E0 CRC64;
     MGMWEEASDT GMKGKKKKKD KNEEEEEERG KKERMVNLTL EMIYLLTGEH YIPRKKSDDG
     GALHAPGSVI QKENNKNDEK ILELMSNIIQ LLTGEVAIRT HHVSIYFSLD EWDNIKGNKV
     LYEEGIKEEP QQLHPLDCEY EDKRDITADL GGTLCYNNET SKIGAEGTDF CAKENLTISP
     VEQPPPANRI KEERASCEEG NQSDCSINPL TEQIQGTDKP TPIMGYSLNN SSANYIKEEV
     VQCHEGNHSD MRIITAPESI LETNTSAAMI RCNLNTSLSA SCEGGNQSDC RINELTEQIQ
     GTDTPTGNIV LYICSECQKH FSTKAGLARH QKTHSVFVGE EHAYGRIHTE EKPFPCSECG
     KRFARRQHLT DHQSSHTGEK PYACSQCEKY FPHRSNLNRH LKLHKGEKPF PCSQCGKRFP
     CVSDLNIHRR VHTGERPYSC SECGKCFKHH SNLTNHQRTH TREKPFSCTE CGKGFKDRSS
     LTVHHRTHTG EKPFSCTECG KGFKDRSSLT VHHRTH